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Home > "P" Clinical Trials Conditions > PTHrP and Osteoporosis  PTHrP and Osteoporosis
PTHrP and Osteoporosis
For Condition: Osteoporosis
Status: Completed
Sponsor(s): National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ,
Synopsis: PTH-related protein, or ''PTHrP'', is a hormone which was discovered in 1987. As its name implies, it is closely related to another hormone discovered in the 1920's named parathyroid hormone or ''PTH''. PTH has been shown to be effective in treating osteoporosis in both animals and humans. PTHrP has been shown to be effective in treating osteoporosis in laboratory animals, and there are strong scientific reasons to think that it may be effective in humans as well. However, no human trials with PTHrP in the treatment of osteoporosis have been performed. The studies in this trial are focussed on determining whether PTHrP can indeed increase bone mass in postmenopausal women with osteoporosis, when administered daily by subcutaneous injection for three months.
Details:
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Placebo Control
Minimum Age/Maximum Age: 50 Years/75 Years
Genders: Female
Protocol Entry Criteria: Inclusion Criteria: - Healthy caucasian postmenopausal females between 50-75 years of age with low bone mineral density at the lumbar spine or hip as measured using dual energy x-ray absorptiometry or DXA. - ON estrogen replacement treatment for at least three years. Exclusion Criteria: - Heart, vascular, kidney, liver, lung, hormonal, musculo-skeletal disease (other than osteoporosis), rheumatic, blood diseases are exclusion criteria. - High blood pressure - Pregnancy - Cancer - Alcohol or drug dependence - Prior use of a drug treatment for osteoporosis such as PTH, bisphosphonates, raloxifene, or calcitonin within the preceding five years
Total Enrollment:
Location and Contact Information:
Overall Study Official:
AndrewStewart, Principal Investigator, University of Pittsburgh
University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania, 15213
United States
Additional Information:
Study ID Numbers: PTHrP and Osteo; RO-1 DK 51081
Study Start Date: June 1999
Record last reviewed: July 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00021827
Other Osteoporosis Studies:
1. Can parathyroid hormone injections reverse glucocorticoid-induced osteoporosis
2. Patient- and Physician-Based Osteoporosis Education
3. Zoledronate in Preventing Bone Loss in Premenopausal Women Receiving Chemotherapy After Surgery For Early Stage Breast Cancer
4. Effects of Jumping on Growing Bones
5. Randomized Study of Growth Hormone on Bone Mineral Density in Patients With Adult Onset Growth Hormone Deficiency
Related Studies:
Other Osteoporosis Clinical Trials
Other Pennsylvania Clinical Trials
Other Pittsburgh Clinical Trials
PTHrP and Osteoporosis
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