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Prevention of transmission of bacteria that cause cavities from mothers to their children Clinical Trials References presented on Clinical Trials Search is not intended to be a substitute for proven healthcare advice, trips or professional assistance by using a real medical. We aren't mDs. Always confer with your physician about Prevention of transmission of bacteria that cause cavities from mothers to their children conditions. Clinical Trials Search.org is a website devoted to listing clinical research studies in human subjects. Prevention of transmission of bacteria that cause cavities from mothers to their children Clinical research trials and Prevention of transmission of bacteria that cause cavities from mothers to their children medical trials take place in hundreds of localities across the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually evaluate the effectualness of new does drugs. The purpose of the studies / projects is to solve specific human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to discover treatments for all sorts of conditions, such as Prevention of transmission of bacteria that cause cavities from mothers to their children. Prevention of transmission of bacteria that cause cavities from mothers to their children Clinical Trials and other clinical trials permit volunteers to access healthcare treatment choices before they are available to the general public. Some times the subjects recieve professional assistance for without cost, and every now and again they are compensated for their time. Sometimes there is a cost for a Prevention of transmission of bacteria that cause cavities from mothers to their children clinical trial. Subjects often receive the most expert healthcare possible for their Prevention of transmission of bacteria that cause cavities from mothers to their children condition. Risks are a reality, nevertheless, and could include additional or frequent dr. calls, healthcare dangers (perhaps life-jeopardising), and/or the treatment being ineffective. Trials are federally governed with stern guidelines to protect clinical trials subjects.
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Home > "P" Clinical Trials Conditions > Prevention of transmission of bacteria that cause cavities from mothers to their children  Prevention of transmission of bacteria that cause cavities from mothers to their children
Prevention of transmission of bacteria that cause cavities from mothers to their children
For Condition: Caries, Dental
Status: No longer recruiting
Sponsor(s): National Institute of Dental and Craniofacial Research (NIDCR) ,
Synopsis: The purpose of this study is to control the levels of bacteria that causes cavities in mothers by a combination of treatments that include fluoride and chlorhexidine varnishes and xylitol-chewing gum before the appearance of teeth in the mouth of their children. By doing that we expect to reduce the acquisition of the bacteria that causes cavities (the mutans streptococci) by the children which in turn will reduce the development of cavities.
Details: Dental decay is the most prevalent affliction in children worldwide. In recent years the occurrence of dental decay has declined dramatically in many industrialized countries subsequent to the widespread availability of fluoride in the water supply and dentifrices. However, in newly industrialized countries such as Brazil, the occurrence of decay is still high, especially among lower income groups. The mutans streptococci (MS) have been convincingly associated with human dental decay and clinical protocols, which seek to reduce the levels of MS invariably, thus resulting in a significant reduction in decay. One of the most important observations from these studies is the possibility that decay and the establishment of MS can be reduced and/or prevented in young children by treating those mothers who are highly infected with MS prior to the eruption of the primary teeth. Other studies indicate that if the MS does not colonize the primary teeth in the first year after their eruption, they are likely to remain caries free during the following years. These findings indicate that delaying the colonization of the MS in the primary dentition may prevent dental decay. The ideal population for such a study can be found in communities without water fluoridation, with a high level of unmet dental care, and who would have frequent access to sugar. Populations in many newly industrialized countries would meet these qualifications. However, it is difficult to perform an interceptive study, such as preventing the transmission of the MS from mother to infant in such countries, as the local dental community has neither the financial and physical resources nor the trained dental personnel. We have found an exception to this in the city of Bauru, Sao Paulo, Brazil. This community of 250,000 residents is situated in the sugar cane growing region of Brazil and boasts the leading dental school in South and Central America. In the investigation described, we will collaborate with the Bauru investigators in a longitudinal randomized clinical trial with the following specific aims: 1) to determine whether the salivary levels of the MS can be reduced in mothers of young infants by an intervention program consisting of restorations, topical fluorides, the use of xylitol chewing gum, chlorhexidine varnishes and oral hygiene instructions; 2) to determine whether this intervention reduces or delays the acquisition of MS in the infants and whether this in turn reduces the subsequent caries incidence in children
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Placebo Control, Single Group Assignment, Efficacy Study
Minimum Age/Maximum Age: 2 Months/35 Years
Genders: Both
Protocol Entry Criteria: Inclusion/Exclusion Criteria: - Mother - 20 teeth - Medically healthy - First-time mother - High levels of the mutans streptococci - No fluoride exposure in the previous 6 months. - Infant - Medically healthy - No cognitive impairment
Total Enrollment: 280
Location and Contact Information:
University of Pittsburgh-Univesidade de Dao Paulo
Bauru, Sao Paulo,
Brazil
Additional Information:
Study ID Numbers: NIDCR-13534;
Study Start Date: January 2001
Record last reviewed: February 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00066040
Other Caries, Dental Studies:
1. Prevention of transmission of bacteria that cause cavities from mothers to their children
Related Studies:
Other Caries, Dental Clinical Trials
Other Sao Paulo Clinical Trials
Other Bauru Clinical Trials
Prevention of transmission of bacteria that cause cavities from mothers to their children
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