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Prevention of Post-Traumatic Osteoarthritis (OA) Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for certified health advice, travels to or treatment by using a genuine physician. We are not physicians. Always consult your dr. on Prevention of Post-Traumatic Osteoarthritis (OA) conditions. Clinical Trials Search.org is a site committed to listing clinical research studies in human subjects. Prevention of Post-Traumatic Osteoarthritis (OA) Clinical research trials and Prevention of Post-Traumatic Osteoarthritis (OA) health trials occur in hundreds of cities throughout the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically assess the effectivity of new drugs. The propose of the studies / undertakings is to resolve certain human health questions. Clinical trials are a popular means for physicians, government agencies, and private sector companies to locate treatments for all sorts of conditions, including Prevention of Post-Traumatic Osteoarthritis (OA). Prevention of Post-Traumatic Osteoarthritis (OA) Clinical Trials and other clinical trials permit volunteers to acquire medical treatment choices before they are available to the masses. Some times the test subjects obtain professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a Prevention of Post-Traumatic Osteoarthritis (OA) clinical trial. Participants oftentimes recieve the most expert healthcare available for their Prevention of Post-Traumatic Osteoarthritis (OA) condition. Hazards are a reality, however, and can include extra or frequent physician visits, health risks (potentially life-endangering), and/or the treatment being uneffective. Trials are federally governed with rigorous guidelines to protect clinical trials subjects.
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Home > "P" Clinical Trials Conditions > Prevention of Post-Traumatic Osteoarthritis (OA)  Prevention of Post-Traumatic Osteoarthritis (OA)
Prevention of Post-Traumatic Osteoarthritis (OA)
For Condition: Osteoarthritis
Status: Recruiting
Sponsor(s): National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) ,
Synopsis: Joint injury and trauma dramatically increase the risk of developing osteoarthritis (OA). The purpose of this study is to determine what factors lead to decreased pain, improved joint function, and repair of the joint surface in post-traumatic OA.
Details: Little work has been done on the pathogenesis and prevention of post-traumatic OA. The human ankle joint provides a unique opportunity for the study of post-traumatic OA because of the low risk of primary OA and the relatively high risk of post-traumatic OA. This study involves a multidisciplinary approach utilizing both laboratory and clinical research to improve understanding of OA and to develop innovative approaches for preventing and treating this disease. Mechanical distraction involves operative placement of specialized pins and rods to hold the joint in place. Some distraction allows for limited motion of the joint, while other distraction holds the joint immobile. The purpose of this study is to elucidate the mechanical factors that lead to restoration of a cartilaginous articular surface, decreased pain, and improved joint function after mechanical distraction of osteoarthritic joints. Participants in this study will be randomly assigned to one of two treatment groups. Group A will be treated with mechanical distraction with motion; Group B will be treated with mechanical distraction without motion. Participants will be followed for 28 months and will have 11 study visits. Most of the study visits will occur during the first half of the study. State-of-the-art techniques for clinical assessment, articular surface imaging, biomechanical modeling, and biochemical testing will be used in this study.
Eligibility:
Study Type: Interventional, Prevention, Randomized, Open Label, Active Control, Parallel Assignment, Safety/Efficacy Study
Minimum Age/Maximum Age: /60 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Symptomatic isolated ankle OA (unilateral Kellgren grade 3, 4, or 5) - Skeletally mature (children included if they have no open growth plates) - Failure of > 1 year nonoperative treatment, including 3 months of continuous treatment with nonsteroidal anti-inflammatory agents and 3 months of unloading treatment (i.e., unloading brace, crutches, cane, walker)
Total Enrollment: 56
Location and Contact Information:
Overall Study Official:
JosephBuckwalter, Principal Investigator, University of Iowa
Dept. of Orthopaedic Surgery, University of Iowa *Recruiting*
Iowa City, Iowa, 52242
United States
Recruiting Lois Lembke 319-335-7548
Additional Information:
Study ID Numbers: NIAMS-082; P50 AR48939
Study Start Date: November 2002
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00054821
Other Osteoarthritis Studies:
1. Aerobic Exercise Intervention for Knee Osteoarthritis
2. Impact of Exercise on Older Persons with Osteoarthritis
3. Knee Stability Training for Knee Osteoarthritis (OA)
4. Brain Imaging - Acupuncture and Osteoarthritis
5. Prevention of Post-Traumatic Osteoarthritis (OA)
Related Studies:
Other Osteoarthritis Clinical Trials
Other Iowa Clinical Trials
Other Iowa City Clinical Trials
Prevention of Post-Traumatic Osteoarthritis (OA)
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