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Preventing Post-Stroke Depression Clinical Trials References presented on Clinical Trials Search is not intended to be a substitute for proven healthcare advice, trips or professional assistance by using a real medical. We aren't mDs. Always confer with your physician about Preventing Post-Stroke Depression conditions. Clinical Trials Search.org is a website devoted to listing clinical research studies in human subjects. Preventing Post-Stroke Depression Clinical research trials and Preventing Post-Stroke Depression medical trials take place in hundreds of localities across the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually evaluate the effectualness of new does drugs. The purpose of the studies / projects is to solve specific human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to discover treatments for all sorts of conditions, such as Preventing Post-Stroke Depression. Preventing Post-Stroke Depression Clinical Trials and other clinical trials permit volunteers to access healthcare treatment choices before they are available to the general public. Some times the subjects recieve professional assistance for without cost, and every now and again they are compensated for their time. Sometimes there is a cost for a Preventing Post-Stroke Depression clinical trial. Subjects often receive the most expert healthcare possible for their Preventing Post-Stroke Depression condition. Risks are a reality, nevertheless, and could include additional or frequent dr. calls, healthcare dangers (perhaps life-jeopardising), and/or the treatment being ineffective. Trials are federally governed with stern guidelines to protect clinical trials subjects.
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Home > "P" Clinical Trials Conditions > Preventing Post-Stroke Depression Preventing Post-Stroke Depression
Preventing Post-Stroke Depression
For Condition: Depression,Cerebrovascular Accident
Status: Recruiting
Sponsor(s): National Institute of Mental Health (NIMH) ,
Synopsis: The purpose of this study is to evaluate the effectiveness of both drug and nondrug treatments in preventing depression after a stroke.
Details: The development of depression after a stroke is a serious condition that can have negative effects on thought, emotions, and overall daily functioning, particularly in the first year following the stroke. Evidence suggests that antidepressants may be used to prevent post-stroke depression. This study will treat nondepressed stroke patients with antidepressants or problem solving therapy (PST) to determine the most effective treatments for preventing depression. Participants in this study will be randomly assigned to receive PST, escitalopram, or placebo (an inactive pill) for 12 months. Participants who display depressive symptoms for 2 weeks or more will be removed from the study. After 12 months, treatment will be discontinued and participants will be monitored for an additional 6 months.
Eligibility:
Study Type: Interventional, Prevention, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study
Minimum Age/Maximum Age: 31 Years/89 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Stroke within the last 120 days Exclusion Criteria: - DSM IV criteria for major or minor depressive disorder - Heart, respiratory, kidney, or liver failure; severely disabling musculoskeletal disorder; or cancer - Diagnosis of neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease, Multiple System Atrophy, or Huntington’s disease - Pre-existing dementia or aphasia with severe language comprehension deficits - Alcohol or substance abuse or dependence within the last 12 months - Recurrent unipolar or bipolar disorder prior to the stroke
Total Enrollment: 201
Location and Contact Information:
University of Iowa Hospitals and Clinics *Recruiting*
Iowa City, Iowa, 52242-1000
United States
Recruiting Stephanie Rosazza 319-353-5807
Burke Rehabilitation Hospital *Recruiting*
White Plains, New York, 10605
United States
Recruiting Pasquale Fonzetti 914-597-2502
University of Chicago *Recruiting*
Chicago, Illinois, 60637
United States
Recruiting Ana Solodkin 773-834-7706
Additional Information:
Study ID Numbers: 65134-01A1;
Study Start Date: September 2002
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00071643
Other Cerebrovascular Accident Studies:
1. Sleep Heart Health Study (SHHS)
2. Study of Abnormal Blood Clotting in Children with Stroke
3. Predictors of Cardiovascular Disease in the Elderly
4. Honolulu Heart Program-Study of Stroke and Dementia
5. Enhancement of Use-Dependent Plasticity by Somatosensory Stimulation in Chronic Stroke
Related Studies:
Other Cerebrovascular Accident Clinical Trials
Other Illinois Clinical Trials
Other Chicago Clinical Trials
Preventing Post-Stroke Depression
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