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Positron Emission Tomography for Detecting Non-small Cell Lung Cancer Clinical Trials Information presented on Clinical Trials Search isn't intended to be a substitute for proven healthcare advice, trips or treatment using a real physician. We are not docs. Always confer with your mD on Positron Emission Tomography for Detecting Non-small Cell Lung Cancer conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Positron Emission Tomography for Detecting Non-small Cell Lung Cancer Clinical research trials and Positron Emission Tomography for Detecting Non-small Cell Lung Cancer medical trials take place in hundreds of localities across the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually measure the effectiveness of new drugs. The intention of the studies / projects is to resolve certain human health questions. Clinical trials are a popular means for physicians, government agencies, and private sector corporations to detect remedies for all forms of circumstances, like Positron Emission Tomography for Detecting Non-small Cell Lung Cancer. Positron Emission Tomography for Detecting Non-small Cell Lung Cancer Clinical Trials and other clinical trials allow for volunteers to undergo healthcare treatment options before they are available to the masses. Most times the participants receive treatment for free, and every now and again they are paid for their time. Occasionally there is a cost for a Positron Emission Tomography for Detecting Non-small Cell Lung Cancer clinical trial. Subjects typically recieve the finest healthcare available for their Positron Emission Tomography for Detecting Non-small Cell Lung Cancer condition. Hazards are a reality, nonetheless, and might include more or frequent mD trips, health risks (potentially life-endangering), and/or the treatment being ineffective. Trials are federally regulated with stern guidelines to protect clinical trials subjects.
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Home > "P" Clinical Trials Conditions > Positron Emission Tomography for Detecting Non-small Cell Lung Cancer  Positron Emission Tomography for Detecting Non-small Cell Lung Cancer
Positron Emission Tomography for Detecting Non-small Cell Lung Cancer
For Condition: squamous cell lung cancer,stage 3A non-small cell lung cancer,adenocarcinoma of the lung,stage 1 non-small cell lung cancer,stage 2 non-small cell lung cancer,large cell lung cancer,bronchoalveolar cell lung cancer
Status: No longer recruiting
Sponsor(s): American College of Surgeons , National Cancer Institute (NCI)
Synopsis: RATIONALE: Imaging procedures, such as positron emission tomography (PET), may improve the ability to detect the extent of non-small cell lung cancer. PURPOSE: Diagnostic trial to study the effectiveness of PET for detecting lesions in patients who have newly diagnosed stage I, stage II, or stage IIIA non-small cell lung cancer.
Details: OBJECTIVES: - Determine the efficacy of fludeoxyglucose F 18 positron emission tomography (FDG-PET) in detecting lesions that would preclude pulmonary resection in patients with non-small cell lung cancer. OUTLINE: This is a multicenter study. Patients receive fludeoxyglucose F 18 (FDG) IV followed 45-60 minutes later by positron emission tomography (PET) imaging. Confirmatory studies, such as biopsy, fine needle aspiration, or other imaging studies are then conducted to confirm the PET findings. Patients with no mediastinal nodal or distant metastases identified by FDG-PET scan may undergo thoracotomy and pulmonary resection within 1 month of evaluation. Patients are followed at 5-6 months after surgery. PROJECTED ACCRUAL: A total of 120-235 patients will be accrued for this study.
Eligibility:
Study Type: Interventional, Diagnostic
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically or cytologically proven clinical stage I, II, or IIIA single lesion bronchogenic non-small cell lung cancer (NSCLC) - Adenocarcinoma - Nonlobar/nondiffuse bronchoalveolar cell carcinoma - Large cell carcinoma - Squamous cell carcinoma - Mediastinal node histology diagnosed by transbronchial biopsy - Biopsy not required if separate ipsilateral lung lesion clearly evident on radiograph - Suspected primary bronchogenic carcinoma allowed without histologic or cytologic proof (e.g., heavy smoker with new peripheral mass with typical appearance of lung cancer on x-ray) if: - Tumor clinically resectable - Exploratory thoracotomy planned - Newly diagnosed, untreated disease amenable to curative surgery - No prior positron emission tomography (PET) scan for NSCLC PATIENT CHARACTERISTICS: Age: - 18 and over Performance status: - Not specified Life expectancy: - Not specified Hematopoietic: - Not specified Hepatic: - Not specified Renal: - Not specified Other: - Able to tolerate PET - Not claustrophobic - Able to lie supine for 1.5 hours - Medically fit for surgical staging procedures or clinical resection - Not pregnant or nursing - Negative pregnancy test - No uncontrolled diabetes mellitus as evidenced by fasting blood glucose greater than 200 mg/dL - No prior malignancy within the past 5 years except completely resected cervical cancer or nonmelanoma skin cancer or cancer that has been treated with potentially curative therapy and is deemed to be at low risk for recurrence PRIOR CONCURRENT THERAPY: Biologic therapy - Not specified Chemotherapy - Not specified Endocrine therapy - Not specified Radiotherapy - Not specified Surgery - See Disease Characteristics
Total Enrollment:
Location and Contact Information:
Overall Study Official:
CarolynReed, Study Chair, Medical University of South Carolina
University of Chicago Cancer Research Center
Chicago, Illinois, 60637-1470
United States
Mount Sinai School of Medicine
New York City, New York, 10029-6574
United States
Morton Plant Mease Health Care
Clearwater, Florida, 33756
United States
UCSF Cancer Center and Cancer Research Institute
San Francisco, California, 94143-0128
United States
Western Pennsylvania Cancer Institute
Pittsburgh, Pennsylvania, 15224
United States
Lutheran General Hospital
Park Ridge, Illinois, 60068
United States
Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242-1009
United States
Massey Cancer Center
Richmond, Virginia, 23298-0037
United States
Indiana University Cancer Center
Indianapolis, Indiana, 46202-5289
United States
Duke Comprehensive Cancer Center
Durham, North Carolina, 27710
United States
Lakeland Regional Medical Center
Lakeland, Florida, 33805-4500
United States
Latter Day Saints Hospital
Salt Lake City, Utah, 84143
United States
Marlene and Stewart Greenebaum Cancer Center, University of Maryland
Baltimore, Maryland, 21201-1590
United States
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, 02114
United States
Jonsson Comprehensive Cancer Center, UCLA
Los Angeles, California, 90095-1781
United States
Medical University of South Carolina
Charleston, South Carolina, 29425-0721
United States
Jameson Memorial Hospital
New Castle, Pennsylvania, 16105
United States
Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212-4772
United States
Veterans Affairs Medical Center - Iowa City
Iowa City, Iowa, 52246-2208
United States
Memorial Sloan-Kettering Cancer Center
New York City, New York, 10021
United States
William Beaumont Hospital
Royal Oak, Michigan, 48073
United States
Barnes-Jewish Hospital
St. Louis, Missouri, 63110
United States
Westmoreland Hospital
Greensburg, Pennsylvania, 15601-2282
United States
Additional Information:
Study ID Numbers: CDR0000067368; ACOSOG-Z0050
Study Start Date:
Record last reviewed: February 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004138
Other Stage 1 Non-Small Cell Lung Cancer Studies:
1. Photodynamic Therapy Plus Brachytherapy in Treating Patients With Lung Cancer
2. Prognostic Study of Metastases in Patients With Stage I, Stage II, or Stage III Non-small Cell Lung Cancer That Can Be Removed by Surgery
3. Vaccine Therapy in Treating Patients With Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer
4. Radiofrequency Ablation During Surgery in Treating Patients With Non-Small Cell Lung Cancer
5. Celecoxib in Preventing Lung Cancer in Former Heavy Smokers
Related Studies:
Other stage 1 non-small cell lung cancer Clinical Trials
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Other New Castle Clinical Trials
Positron Emission Tomography for Detecting Non-small Cell Lung Cancer
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