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Pollutant altered allergic responses



Pollutant altered allergic responses

For Condition: Allergy,Allergic Rhinitis
Status: Recruiting
Sponsor(s): National Institute of Environmental Health Sciences (NIEHS) ,
Synopsis: This study is designed to investigate whether exposure to particulate air pollution increases the allergic response to allergens. Research studies suggest that symptoms in individuals with allergies may be aggravated by exposure to particulate air pollution. We sought to experimental determine this by exposing human volunteers to combustion particles, a component of air pollution, and then challenge them with an allergen such as ragweed or oak tree pollen. Using biological tests we can measure whether the allergen response is magnified by prior particulate exposure.
Details: To study whether particulates enhance the allergic response, we chose the upper airway as a model of allergic inflammation and nasal lavage as a non-invasive method for obtaining samples. The nasal cavity is both an excellent model of allergic inflammation and provides an easily accessible site for study. We measured inflammatory cells and cytokines in the nasal lavage fluid. Our specific hypothesis was that particulate exposure prior to allergen challenge would enhance inflammatory cell recruitment and expression of inflammatory cytokines.
Eligibility:
Study Type:
  Observational, Natural History, Longitudinal, Random Sample, Prospective Study
Minimum Age/Maximum Age: 18 Years/60 Years
Genders: Both
Protocol Entry Criteria: Adult without a history of asthma or respiratory disease.
Total Enrollment: 20

Location and Contact Information:

Harvard School of Public Health *Recruiting*
Boston,  Massachusetts,  02115
United States
Recruiting Russ  Hauser 617-432-3326


Additional Information:
Study ID Numbers:
  8077-CP-001; 
Study Start Date: December 1998
Record last reviewed: July 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00011440

Other Allergy Studies:
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2. Pollutant altered allergic responses

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