Search Clinical Trials
 
By Condition
 
By Location (USA)
 
By Location (Other)
 
By Sponsor
 
Resources
 
Privacy Policy
 
About Us
Disclaimer
Phosphorus 32 in Treating Patients With Glioblastoma Multiforme Clinical Trials Resources presented on Clinical Trials Search isn't meant to be a substitute for qualified health advice, visits or professional assistance with a real medical. We aren't doctors. Always consult your mD about Phosphorus 32 in Treating Patients With Glioblastoma Multiforme conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Phosphorus 32 in Treating Patients With Glioblastoma Multiforme Clinical research trials and Phosphorus 32 in Treating Patients With Glioblastoma Multiforme health trials occur in a lot of of places throughout the United States of America. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically assess the effectivity of new does drugs. The role of the studies / projects is to resolve certain human healthcare questions. Clinical trials are a popular way for doctors, government agencies, and private sector corporations to detect remedies for all varieties of circumstances, such as Phosphorus 32 in Treating Patients With Glioblastoma Multiforme. Phosphorus 32 in Treating Patients With Glioblastoma Multiforme Clinical Trials and other clinical trials allow volunteers to obtain health treatment choices before they are available to the general public. Most times the human subjects recieve professional assistance for free of charge, and every now and again they are paid for their time. Sometimes there is a cost for a Phosphorus 32 in Treating Patients With Glioblastoma Multiforme clinical trial. Human subjects frequently get the finest healthcare available for their Phosphorus 32 in Treating Patients With Glioblastoma Multiforme condition. Risks are a reality, however, and may include extra or frequent physician visits, medical dangers (possibly life-threatening), and/or the treatment being uneffective. Trials are federally governed with strict guidelines to protect clinical trials patients.

Home > "P" Clinical Trials Conditions > Phosphorus 32 in Treating Patients With Glioblastoma Multiforme

Phosphorus 32 in Treating Patients With Glioblastoma Multiforme



Phosphorus 32 in Treating Patients With Glioblastoma Multiforme

For Condition: recurrent adult brain tumor,adult glioblastoma multiforme
Status: Recruiting
Sponsor(s): Center for Molecular Medicine ,
Synopsis: RATIONALE: Radioactive drugs such as phosphorus 32 may be able to kill tumor cells. PURPOSE: Phase I trial to study the effectiveness of phosphorus 32 in treating patients who have glioblastoma multiforme.
Details: OBJECTIVES: - Determine the dosimetry toxicity of interstitial colloidal phosphorus P32 (C P32) in patients with recurrent or poor prognosis grade 4 astrocytoma. - Determine the maximum tolerated dose of C P32 administered directly into the tumor of these patients. - Determine the maximum tolerated fractionated dose of interstitial C P32 in these patients. - Determine the therapeutic response rate to the acceptable single and fractionated doses of C P32 in these patients. OUTLINE: This is a dose-escalation study. Patients receive interstitial colloidal phosphorus P32 (C P32) on day 0. Courses repeat every 4-6 weeks in the absence of disease progression or unacceptable toxicity. Cohorts of 3 patients receive escalating doses of C P32 until the maximum tolerated dose (MTD) is determined. The MTD is defined the dose at which 2 of 3 patients experience dose-limiting toxicity. Patients are followed at 1, 2, 4, 6, 9, 15, and 24 weeks. PROJECTED ACCRUAL: A minimum of 12 patients will be accrued for this study.
Eligibility:
Study Type:  Interventional, Treatment
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically proven grade 4 astrocytoma (glioblastoma) - Failed external beam radiotherapy and/or surgery OR - Poor prognosis disease - No clinical evidence of metastatic disease within the CNS other than the primary tumor site - Stereotactic biopsy or gross total excision with residual tumor - Lesion 3 to 5 cm in size - No spinal cord tumor(s) PATIENT CHARACTERISTICS: Age: - 18 and over Performance status: - Karnofsky 70-100% Life expectancy: - Not specified Hematopoietic: - WBC at least 3,000/mm3 - Neutrophil count at least 1,900/mm3 - Platelet count at least 100,000/mm3 - Hemoglobin at least 9 g/dL (transfusion allowed) Hepatic: - Not specified Renal: - Creatinine no greater than 1.5 mg/dL - BUN less than 25 mg/dL Other: - Not pregnant - Negative pregnancy test - Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: - Not specified Chemotherapy: - Not specified Endocrine therapy: - Not specified Radiotherapy: - See Disease Characteristics Surgery: - See Disease Characteristics
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
StanleyOrder,  Study Chair,  Center for Molecular Medicine

Center for Molecular Medicine *Recruiting*
Garden City,  New York,  11530
United States
Recruiting Mitchell  Levine 516-222-2727


Additional Information:
Study ID Numbers:  CDR0000067357;  CMM-2,NCI-V99-1575
Study Start Date: 
Record last reviewed: June 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004129

Other Adult Glioblastoma Multiforme Studies:
1. Radiation Therapy Followed by Bleomycin in Treating Adult Patients With Newly Diagnosed Supratentorial Glioblastoma Multiforme

2. Boron Neutron Capture Therapy in Treating Patients With Glioblastoma Multiforme or Melanoma Metastatic to the Brain

3. High-Dose Methotrexate and Leucovorin Followed By Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

4. Vaccine Therapy in Treating Patients With Malignant Glioma

5. CCI-779 in Treating Patients With Malignant Glioma

Related Studies:

Other adult glioblastoma multiforme Clinical Trials
Other New York Clinical Trials
Other Garden City Clinical Trials

Phosphorus 32 in Treating Patients With Glioblastoma Multiforme
Modify your Search

  Other adult glioblastoma multiforme Clinical Trials
  Other New York Clinical Trials
  Other Garden City Clinical Trials


Warning: include(/var/www/cgi-bin/traxis/counter.php) [function.include]: failed to open stream: No such file or directory in /home/cts/domains/clinicaltrialssearch.org/public_html/index.php on line 103

Warning: include() [function.include]: Failed opening '/var/www/cgi-bin/traxis/counter.php' for inclusion (include_path='.:/usr/local/lib/php') in /home/cts/domains/clinicaltrialssearch.org/public_html/index.php on line 103