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Phase II Study of Recombinant Relaxin for Progressive Systemic Sclerosis Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for certified medical advice, calls or professional assistance using a genuine dr.. We aren't physicians. Always confer with your dr. on Phase II Study of Recombinant Relaxin for Progressive Systemic Sclerosis conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Phase II Study of Recombinant Relaxin for Progressive Systemic Sclerosis Clinical research trials and Phase II Study of Recombinant Relaxin for Progressive Systemic Sclerosis medical trials happen in hundreds of localities throughout the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically measure the effectualness of new does drugs. The intent of the studies / undertakings is to answer particular human health questions. Clinical trials are a popular manner for physicians, government agencies, and private sector corporations to find cures for all kinds of circumstances, like Phase II Study of Recombinant Relaxin for Progressive Systemic Sclerosis. Phase II Study of Recombinant Relaxin for Progressive Systemic Sclerosis Clinical Trials and other clinical trials permit volunteers to acquire healthcare treatment options before they are available to the general public. Some times the subjects acquire professional assistance for free, and sometimes they are paid for their time. Sometimes there is a cost for a Phase II Study of Recombinant Relaxin for Progressive Systemic Sclerosis clinical trial. Participants frequently obtain the most expert healthcare available for their Phase II Study of Recombinant Relaxin for Progressive Systemic Sclerosis condition. Dangers are a reality, nevertheless, and can include more or frequent doctor calls, health risks (potentially life-jeopardizing), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials subjects.

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Phase II Study of Recombinant Relaxin for Progressive Systemic Sclerosis



Phase II Study of Recombinant Relaxin for Progressive Systemic Sclerosis

For Condition: Systemic Sclerosis
Status: Completed
Sponsor(s): National Center for Research Resources (NCRR) , National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS),Stanford University
Synopsis: OBJECTIVES: I. Determine whether parenteral relaxin improves skin tightness, Raynaud's phenomenon, digital morbidity, and digital ulcers in a patient with progressive systemic sclerosis (scleroderma). II. Determine whether relaxin decreases collagen production by fibroblasts in vivo and cultured from skin biopsies.
Details: PROTOCOL OUTLINE: This is a compassionate use study. The patient is treated with subcutaneous injections of recombinant relaxin for approximately 12 months. If clinically indicated, therapy may be extended.
Eligibility:
Study Type:
  Interventional, Treatment, Non-Randomized
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- - Progressive systemic sclerosis (scleroderma) - No pregnant or nursing women
Total Enrollment: 1

Location and Contact Information:

Overall Study Official:
G.Herron,  Study Chair,  Stanford University


Additional Information:
Study ID Numbers:
  199/12015;  SUMC-37488
Study Start Date: December 1991
Record last reviewed: April 2000
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004380

Other Systemic Sclerosis Studies:
1. Safety, Tolerability, and Pharmacokinetics of CAT-192 (Human Anti-TGF-Beta1 Monoclonal Antibody) in Patients with Early Stage Diffuse Systemic Sclerosis

2. Phase II Pilot Study of Cyclophosphamide and Rabbit Anti-Thymocyte Globulin as Salvage Therapy in Patients With Diffuse Systemic Sclerosis

3. Psychological Treatments for Scleroderma

4. Pilot Study of Total Body Irradiation in Combination With Cyclophosphamide, Anti-thymocyte Globulin, and Autologous CD34-Selected Peripheral Blood Stem Cell Transplantation in Children With Refractory Autoimmune Disorders

5. Genetic Study of the FBN1 Gene and Fibrillin-1 Abnormalities in Choctaw Native Americans and Other Patients with Systemic Sclerosis

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