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Phase 1-2a Study of TLK286 in Combination with Paraplatin (Carboplatin) in Recurrent Ovarian Cancer



Phase 1-2a Study of TLK286 in Combination with Paraplatin (Carboplatin) in Recurrent Ovarian Cancer

For Condition: Ovarian Neoplasms
Status: Recruiting
Sponsor(s): Telik ,
Synopsis: This is a dose-ranging, open label, Phase 1-2a study of TLK286 in combination with Paraplatin (carboplatin) in patients with recurrent ovarian cancer.
Details:
Eligibility:
Study Type:
  Interventional, Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Safety/Efficacy Study
Minimum Age/Maximum Age: 18 Years/
Genders: Female
Protocol Entry Criteria: Inclusion Criteria - Histologically or cytologically confirmed diagnosis of epithelial cancer of the ovary, fallopian tube, or primary peritoneal cancer - Recurrent ovarian cancer or persistent disease following primary treatment - At least one, but no more than four, prior chemotherapy regimens (all platinum-containing counted as one) - At least 18 years of age Exclusion Criteria - Pregnant or lactating women - History of prior malignancy except for adequately treated carcinoma in situ of the uterine cervix, basal cell or squamous cell skin cancer, or other cancer for which patient has been disease-free for at least 2 years - Known leptomeningeal metastases or carcinomatous meningitis - Having received whole pelvis radiation therapy
Total Enrollment: 28

Location and Contact Information:

Midwest Cancer Research Group, Inc. *Recruiting*
Skokie,  Illinois,  60077
United States
Recruiting Sharon  Goldman 847-673-1999

M.D. Anderson Cancer Center *Recruiting*
Houston,  Texas,  77030
United States
Recruiting Mercedes  Bolanos-Clark 713-563-1788


Additional Information:
Study ID Numbers:
  TLK286.2018; 
Study Start Date: December 2002
Record last reviewed: May 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00051948

Other Ovarian Neoplasms Studies:
1. A Phase II Trial of 72-Hour Continuous IV Infusion of 9-Aminocamptothecin with G-CSF Support in Patients with Advanced Ovarian Cancer Previously Treated with Paclitaxel and Cisplatin

2. Phase II Trial of Gleevec in Patients with Advanced Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer

3. Outcomes of Education and Counseling for BRCA1 Testing

4. Study of Motexafin Gadolinium and Docetaxel for Advanced Solid Tumors

5. Massage Therapy for Cancer-Related Fatigue

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Phase 1-2a Study of TLK286 in Combination with Paraplatin (Carboplatin) in Recurrent Ovarian Cancer

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