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Periodontitis and Cardiovascular Events or "PAVE" Clinical Trials Information presented on Clinical Trials Search isn't designed to be a substitute for certified healthcare advice, travels to or professional assistance using a genuine medical doctor. We are not physicians. Always confer with your dr. about Periodontitis and Cardiovascular Events or "PAVE" conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Periodontitis and Cardiovascular Events or "PAVE" Clinical research trials and Periodontitis and Cardiovascular Events or "PAVE" medical trials happen in hundreds of places across the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually measure the effectualness of new drugs. The intention of the studies / undertakings is to solve certain human healthcare questions. Clinical trials are a popular manner for mDs, government agencies, and private sector companies to locate treatments for all forms of circumstances, such as Periodontitis and Cardiovascular Events or "PAVE". Periodontitis and Cardiovascular Events or "PAVE" Clinical Trials and other clinical trials allow for volunteers to undergo medical treatment choices before they are available to the general public. Some times the human subjects get treatment for free of charge, and sometimes they are paid for their time. Occasionally there is a cost for a Periodontitis and Cardiovascular Events or "PAVE" clinical trial. Participants frequently get the best healthcare available for their Periodontitis and Cardiovascular Events or "PAVE" condition. Risks are a reality, nonetheless, and can include extra or frequent physician trips, medical risks (possibly life-jeopardising), and/or the treatment being ineffective. Trials are federally governed with exacting guidelines to protect clinical trials subjects.
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Home > "P" Clinical Trials Conditions > Periodontitis and Cardiovascular Events or "PAVE"  Periodontitis and Cardiovascular Events or "PAVE"
Periodontitis and Cardiovascular Events or "PAVE"
For Condition: Myocardial Infarction,Cardiovascular Disease,Cerebrovascular Accident,Coronary Heart Disease
Status: Recruiting
Sponsor(s): National Institute of Dental and Craniofacial Research (NIDCR) ,
Synopsis: The purpose of this study is to determine if treating periodontal infections (gum problems) will lead to fewer heart problems in patients at high risk for cardiovascular disease.
Details: There is growing evidence of a strong association between infection and atherosclerosis as well as a specific link between periodontal infection (gum problems) and heart disease. Previous studies have established possible effective treatments of periodontal disease. These treatments may lead to fewer heart events in persons at high risk for cardiovascular disease. In contrast to previous heart disease studies, the primary treatment in this project is directed toward infectious agents at periodontal sites. This project is a pilot randomized clinical trial to test the feasibility of selecting and refining a periodontal infection treatment and examining the effect of that treatment on future heart events. It is a multi-center planning and pilot study involving five investigational centers at the University at Buffalo (lead and overall coordinating center), University of North Carolina, Boston University, Kaiser Permanente/Oregon Health Science University, University of Maryland, and a data coordinating center at the University of North Carolina. Central microbiology and cytokine laboratories and a biologic specimen bank are also included. A team of cardiologists, periodontists, epidemiologists, infectious disease specialists, biostatisticians, research nurses in periodontics and cardiology, and data managers has been assembled to accomplish the research with a careful, cost-effective approach. The ultimate goal is to develop a definitive randomized clinical trial that will include about 4,000 participants from approximately 15 centers across the United States
Eligibility:
Study Type: Interventional, Treatment, Randomized, Single Blind, Active Control, Factorial Assignment, Efficacy Study
Minimum Age/Maximum Age: /75 Years
Genders: Both
Protocol Entry Criteria: Eligibility: - Aged 75 years or less AND 50% or more blockage of at least one artery in the heart, - Heart problems in the last 3 years (including previous heart attack), - Previous heart bypass surgery, or previous heart angioplasty with or without a stent, AND at least 6 natural teeth present in the mouth AND evidence of mild to severe gum problems. Exclusion: Any of the following: - A major illness requiring hospitalization, - Renal dialysis, - Serum creatinine > 3 mg/dl, - Organ transplant recipient requiring immunosuppression medication, - Surgery needed in the next 3 years, - Chemotherapy in the past 3 years, - Head and/or neck radiation at any time in the past, - Liver dysfunction, - Class IV congestive heart failure, - Drug or alcohol abuse, - Pacemaker or AICD/defibrillator.
Total Enrollment: 400
Location and Contact Information:
Overall Study Official:
JamesBeck, Principal Investigator, University of NC, School of Dentistry, Chapel Hill, NC
University at Buffalo *Recruiting*
Buffalo, New York, 14214
United States
Recruiting Robert Genco 716-829-2854
Additional Information:
Study ID Numbers: NIDCR-13940;
Study Start Date: January 2003
Record last reviewed: August 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00066053
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3. Comparative Efficacy Evaluation of Lipids when Treated with Niaspan & Statin or Other Lipid-Modifying Therapies-COMPELL
4. Periodontitis and Cardiovascular Events or "PAVE"
5. Cardio Vascu-Grow for treatment of coronary heart disease
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Periodontitis and Cardiovascular Events or "PAVE"
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