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Paclitaxel, Carboplatin, and Radiation Therapy With or Without Adjuvant Paclitaxel and Carboplatin in Treating Patients With Stage II or Stage III Unresectable Non-Small Cell Lung Cancer Clinical Trials Information presented on Clinical Trials Search isn't designed to be a substitute for certified healthcare advice, travels to or professional assistance using a genuine medical doctor. We are not physicians. Always confer with your dr. about Paclitaxel, Carboplatin, and Radiation Therapy With or Without Adjuvant Paclitaxel and Carboplatin in Treating Patients With Stage II or Stage III Unresectable Non-Small Cell Lung Cancer conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Paclitaxel, Carboplatin, and Radiation Therapy With or Without Adjuvant Paclitaxel and Carboplatin in Treating Patients With Stage II or Stage III Unresectable Non-Small Cell Lung Cancer Clinical research trials and Paclitaxel, Carboplatin, and Radiation Therapy With or Without Adjuvant Paclitaxel and Carboplatin in Treating Patients With Stage II or Stage III Unresectable Non-Small Cell Lung Cancer medical trials happen in hundreds of places across the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually measure the effectualness of new drugs. The intention of the studies / undertakings is to solve certain human healthcare questions. Clinical trials are a popular manner for mDs, government agencies, and private sector companies to locate treatments for all forms of circumstances, such as Paclitaxel, Carboplatin, and Radiation Therapy With or Without Adjuvant Paclitaxel and Carboplatin in Treating Patients With Stage II or Stage III Unresectable Non-Small Cell Lung Cancer. Paclitaxel, Carboplatin, and Radiation Therapy With or Without Adjuvant Paclitaxel and Carboplatin in Treating Patients With Stage II or Stage III Unresectable Non-Small Cell Lung Cancer Clinical Trials and other clinical trials allow for volunteers to undergo medical treatment choices before they are available to the general public. Some times the human subjects get treatment for free of charge, and sometimes they are paid for their time. Occasionally there is a cost for a Paclitaxel, Carboplatin, and Radiation Therapy With or Without Adjuvant Paclitaxel and Carboplatin in Treating Patients With Stage II or Stage III Unresectable Non-Small Cell Lung Cancer clinical trial. Participants frequently get the best healthcare available for their Paclitaxel, Carboplatin, and Radiation Therapy With or Without Adjuvant Paclitaxel and Carboplatin in Treating Patients With Stage II or Stage III Unresectable Non-Small Cell Lung Cancer condition. Risks are a reality, nonetheless, and can include extra or frequent physician trips, medical risks (possibly life-jeopardising), and/or the treatment being ineffective. Trials are federally governed with exacting guidelines to protect clinical trials subjects.

Home > "P" Clinical Trials Conditions > Paclitaxel, Carboplatin, and Radiation Therapy With or Without Adjuvant Paclitaxel and Carboplatin in Treating Patients With Stage II or Stage III Unresectable Non-Small Cell Lung Cancer

Paclitaxel, Carboplatin, and Radiation Therapy With or Without Adjuvant Paclitaxel and Carboplatin in Treating Patients With Stage II or Stage III Unresectable Non-Small Cell Lung Cancer



Paclitaxel, Carboplatin, and Radiation Therapy With or Without Adjuvant Paclitaxel and Carboplatin in Treating Patients With Stage II or Stage III Unresectable Non-Small Cell Lung Cancer

For Condition: stage 3B non-small cell lung cancer,stage 2 non-small cell lung cancer,stage 3A non-small cell lung cancer
Status: Recruiting
Sponsor(s): GERCOR ,
Synopsis: RATIONALE: Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known whether chemotherapy combined with radiation therapy is more effective with or without adjuvant chemotherapy in treating unresectablestage II or stage III non-small cell lung cancer. PURPOSE: Randomizedphase III trial to compare the effectiveness of paclitaxel and carboplatin combined with radiation therapy with or without adjuvant paclitaxel and carboplatin in treating patients who have unresectable stage II or stage III non-small cell lung cancer.
Details: OBJECTIVES: Primary - Compare the progression-free survival of patients with stage II or III unresectable non-small cell lung cancer treated with paclitaxel, carboplatin, and radiotherapy with or without adjuvant paclitaxel and carboplatin. Secondary - Compare the objective response rate in patients treated with these regimens. - Compare the overall survival of patients treated with these regimens. - Compare the toxicity of these regimens in these patients. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to radiotherapy regimen (conformational vs nonconformational). Patients receive paclitaxel IV over 1 hour and carboplatin IV over 30 minutes once weekly for up to 6 weeks. Patients concurrently undergo radiotherapy 5 days a week for 7-7.5 weeks. Three weeks after completion of chemoradiotherapy, patients with stable or responding disease are randomized to 1 of 2 treatment arms. - Arm I: Patients undergo routine follow-up. - Arm II: Patients receive paclitaxel IV over 3 hours and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days for a maximum of 3 courses. Patients are followed every 3 months for 2 years and then every 6 months thereafter. PROJECTED ACCRUAL: A total of 390 patients will be accrued for this study within 3 years.
Eligibility:
Study Type:
  Interventional, Treatment
Minimum Age/Maximum Age: 18 Years/79 Years
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically confirmed non-small cell lung cancer - Stage II or III disease - Not amenable to surgery - Measurable or evaluable disease - No T4 apical localization - Lesions able to be covered in a 60 Gy minimum volume of radiation - No pleural effusion PATIENT CHARACTERISTICS: Age - 18 to 79 Performance status - ECOG 0-2 Life expectancy - More than 3 months Hematopoietic - Absolute neutrophil count > 1,500/mm^3 - Platelet count > 100,000/mm^3 Hepatic - Bilirubin < 1.5 times upper limit of normal (ULN) Renal - Creatinine < 1.25 times ULN Cardiovascular - No unstable heart disease Pulmonary - No ventilation dysfunction that would preclude radiotherapy Other - No weight loss of 15% or more within the past 2 months - No uncontrolled infection - No other prior malignancy except curatively treated basal cell skin cancer or carcinoma in situ of the cervix PRIOR CONCURRENT THERAPY: Biologic therapy - Not specified Chemotherapy - More than 6 months since prior neoadjuvant chemotherapy - No prior adjuvant chemotherapy Endocrine therapy - Not specified Radiotherapy - See Disease Characteristics - No prior radiotherapy Surgery - Not specified Other - No other concurrent clinical trial participation
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
JeanMorere,  ,  Hopital Avicenne

Centre Hospitalier Regional Metz Thionville *Recruiting*
Thionville,  ,  57126
France
Recruiting Alain  Beraud 33-3-8255-8899

Clinique du Petit Colmouilins *Recruiting*
Harfleur,  ,  76700
France
Recruiting Jean  Duhamel 33-2-3555-6910

Centre Rene Huguenin *Recruiting*
Saint Cloud,  ,  92211
France
Recruiting E.G.C.  Brain 33-147-111-515

Clinique Clementville *Recruiting*
Montpellier,  , 
France
Recruiting Robert  Regal 33-04-6792-6155

Clinique du Pont de Chaume *Recruiting*
Montauban,  ,  82017
France
Recruiting Alain  Redon 33-05-6368-3333

Clinique les Bleuets *Recruiting*
Reims,  ,  51100
France
Recruiting Tredaniel  Picavet 33-3-26-06-81-81

Hopital Avicenne *Recruiting*
Bobigny,  ,  93009
France
Recruiting Jean  Morere 33-1-48-955-032

Hopital Tenon *Recruiting*
Paris,  ,  75970
France
Recruiting Jean-Pierre  Lotz 33-1-5601-6058

Clinique De Valdegour *Recruiting*
Nimes,  ,  30900
France
Recruiting Arnaud  Boutte 33-4-6662-5800

Institut Sainte Catherine *Recruiting*
Avignon,  ,  84082
France
Recruiting Francois  Reboul 33-90-27-61-61

Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle *Recruiting*
Montpellier,  ,  34298
France
Recruiting Claire  Lemanski 33-04-6761-3134

Hopital Fontenoy *Recruiting*
Chartres,  ,  28018
France
Recruiting A.  Salemkour 33-0-237303270

Hopital Robert Boulin *Recruiting*
Libourne,  ,  33500
France
Recruiting Bertrand  Darpeix 33-5-5755-3434

Hopital Saint-Louis *Recruiting*
Paris,  ,  75475
France
Recruiting Christophe  Hennequin 33-1-4249-4949

Polyclinique de L'Ormeau *Recruiting*
Tarbes,  ,  65000
France
Recruiting Bernard  Couderc 33-056-293-5929

Polyclinique Saint - Roch *Recruiting*
Montpellier,  ,  34000
France
Recruiting Jean-Louis  Baticle 33-4-9961-4000

Centre Hospitalier General *Recruiting*
Le Mans,  ,  72037
France
Recruiting F-Xavier  Lebas 33-2-43-43-25-43

Centre d'Oncologie et de Radiotherapie du Parc *Recruiting*
Dijon,  ,  21000
France
Recruiting Thierry  Altwegg 33-3-80-673-010

Clinique Saint - Pierre *Recruiting*
Perpignan,  , 
France
Recruiting Daniel  Castera 33-09-6839-0742

Polyclinique Bordeaux Nord Aquitaine *Recruiting*
Boucher,  ,  33300
France
Recruiting Francois  Guichard 33-5-56-43-73-54

Centre Hospitalier Chateaudun *Recruiting*
Chateaudun,  ,  28200
France
Recruiting  Rabut 33-02-3744-4040

Polyclinique De Courlancy *Recruiting*
Reims,  ,  F-51100
France
Recruiting Philippe  Colin 33-3-2684-0284

C.H.G. Beauvais *Recruiting*
Beauvais,  ,  60021
France
Recruiting J.L.  Dutel 33-344-112-309

Centre D'Oncologie De Gentilly *Recruiting*
Nancy,  ,  54100
France
Recruiting Pierre  Baumann 33-3-8393-5005

Centre Hospitalier de la Cote Basque *Recruiting*
Bayonne,  ,  64109
France
Recruiting Dominique  Larregain-Tournier 33-05-5944-3535

Clinique du Cedre *Recruiting*
Bois-Guillaume,  ,  76230
France
Recruiting  Labbe 33-02-3559-5959

Clinique Tivoli *Recruiting*
Bordeaux,  ,  F-33030
France
Recruiting Patrick  Bonichon 33-5-5611-6000

C.H.G Laval *Recruiting*
Laval,  ,  53024
France
Recruiting Jean  Le Lain 33-02-4366-5000

Centre Hospitalier Chaumont *Recruiting*
Chaumont,  ,  52000
France
Recruiting Bernard  Simon 33-03-2530-7030

C.H. Du Havre *Recruiting*
Montivilliers,  ,  F-76290
France
Recruiting Marc  Peureux 33-02-3273-3232

Centre Hospitalier de Saint - Brieuc *Recruiting*
Saint-Brieuc,  ,  22023
France
Recruiting Eric  Briens 33-2-9601-7123

Centre Hospitalier de Valenciennes *Recruiting*
Valenciennes,  , 
France
Recruiting Jean  Roux 33-03-2714-2434

Clinique Armoricaine De Radiologie *Recruiting*
Saint Brieux,  ,  F-22015
France
Recruiting Anne-Claire  Hardy-Bessard 33-2-96-75-22-16

Clinique Chenieux *Recruiting*
Limoges,  ,  87000
France
Recruiting Jean-Jacques  Pavy 33-05-5545-4040

Clinique des Cedres *Recruiting*
Cornebarrieu,  ,  31700
France
Recruiting Pierre  Mourlalette 33-05-6213-3203

Hopital Jean Monnet *Recruiting*
Epinal,  ,  BP590
France
Recruiting  Collignon 33-3-2968-7000

Hopital Saint Andre *Recruiting*
Bordeaux,  ,  33075
France
Recruiting Renaud  Trouette 33-05-795-808

Polyclinique Du Parc Centre Maurice Tubiana *Recruiting*
Caen,  ,  14052
France
Recruiting Patrick  Allain 33-23-182-8282

Centre Eugene Marquis *Recruiting*
Rennes,  ,  35042
France
Recruiting Mohamed  Hassel 33-2-99-25-3000

Centre Guillaume Le Conquerant *Recruiting*
Le Havre,  ,  76600
France
Recruiting Laurent  Martin 33-2-3522-7161

Centre Hospitalier De Vernon *Recruiting*
Vernon,  ,  27200
France
Recruiting Nadege  Gueteau 33-2-3271-6600

Centre Hospitalier D'Evreux *Recruiting*
Evreux,  ,  27000
France
Recruiting Jacques  Bres 33-2-3233-8000

Centre Hospitalier Robert Bisson *Recruiting*
Lisieux,  ,  14100
France
Recruiting Driss  Abouz 33-23-182-8282

Centre Mallet - Proux *Recruiting*
Laval,  ,  53000
France
Recruiting Daniel  Martin 33-02-4364-1333

Clinique Medico Chirurgicale Teissier Groupe *Recruiting*
Valenciennes,  , 
France
Recruiting  Dufour 33-3-2714-2434

Clinique Pasteur *Recruiting*
Evreux,  ,  27000
France
Recruiting Daniel  Lepille 33-02-3238-1202

Clinique Saint Vincent *Recruiting*
Saint-Gregoire,  ,  35700
France
Recruiting James  Bassoulet 33-2-992-333-33

C. H. De Saumur *Recruiting*
Saumur,  ,  49403
France
Recruiting Michel  Maigre 33-2-4153-3030

Centre Frederic Joliot *Recruiting*
Rouen,  ,  76000
France
Recruiting Philippe  Gomez 33-2-3276-4076

Centre Hospitalier de Mulhouse *Recruiting*
Mulhouse,  ,  68051
France
Recruiting Anne-Marie  Elgard 33-3-8964-6464

Oncologie Medicale *Recruiting*
Saint-Jean,  ,  31240
France
Recruiting Franck  Burki 33-61-37-81-81

C. H. Du Mans *Recruiting*
Le Mans,  ,  72037
France
Recruiting Isabelle  Simon 33-02-4343-4343

C.H.G. De Pau *Recruiting*
Pau,  ,  64000
France
Recruiting Marie  Benichou 33-5-59-924-982

Centre Hospitalier Bayeux *Recruiting*
Bayeux,  ,  14400
France
Recruiting Jean-Paul  Leterrier 33-02-3151-5151

Centre Hospitalier d'Annecy *Recruiting*
Annecy,  ,  74011 Cedex
France
Recruiting S.  Hominal 33-04-5088-3341

Clinique de le Louviere *Recruiting*
Lille,  ,  F-59800
France
Recruiting Francois  Fortin 33-3-2016-0530

Hopital Duffaut *Recruiting*
Avignon,  ,  84902
France
Recruiting Alain  Rabanit 33-04-3275-3333

Hopital Notre-Dame de Bon Secours *Recruiting*
Metz,  ,  55038
France
Recruiting Nadine  Paillot 33-3-87-55-36-95

Medipole Gentilly Saint-Jacques *Recruiting*
Maxeville,  ,  54320
France
Recruiting  Issartel 33-03-8393-5080

Centre d'Oncologie et de Radiotherapie de Chaumont le Bois *Recruiting*
Chaumont,  ,  52000
France
Recruiting Francois  Bildstein 33-3-2532-3960

CHR D'Orleans - Hopital de la Source *Recruiting*
Orleans,  ,  45100
France
Recruiting Nadia  Raban 33-02-3851-4444

Clinique de l'Orangerie *Recruiting*
Strasbourg,  ,  67010
France
Recruiting Jean-Philippe  Wagner 33-3-8856-7300

Groupe Medical St. Remy *Recruiting*
Reims,  ,  51100
France
Recruiting Frederic  Masure 33-03-2685-2006

Hopital Louis Pasteur *Recruiting*
Comar,  ,  68021
France
Recruiting Jean  Poster 33-03-8912-4000

Centre du Rouget *Recruiting*
Sarcelles,  ,  95250
France
Recruiting Aime-Andre  Kanoui 33-13-990-4955

Centre Hospitalier De Saint Dizier *Recruiting*
Saint-Dizier,  ,  52100
France
Recruiting  Billon 33-3-2556-8484

Centre Jean Bernard *Recruiting*
Le Mans,  ,  72000
France
Recruiting Gerard  Ganem 33-2-4324-1266

Maison Medicale Marzet *Recruiting*
Pau,  ,  64000
France
Recruiting Jean-Pierre  Dujol 33-5-5992-7272


Additional Information:
Study ID Numbers:
  CDR0000350015;  FRE-GERCOR-B00-1,EU-20330
Study Start Date: 
Record last reviewed: January 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00077220

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