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Home > "O" Clinical Trials Conditions > Ozone and Rhinovirus-Induced Disease in Asthmatics  Ozone and Rhinovirus-Induced Disease in Asthmatics
Ozone and Rhinovirus-Induced Disease in Asthmatics
For Condition: Asthma
Status: Recruiting
Sponsor(s): National Institute of Environmental Health Sciences (NIEHS) ,
Synopsis: In the U.S., morbidity associated with human rhinovirus (RV) infection represents a major health problem. In asthmatics, up to 80% of asthma exacerbations are associated with upper respiratory infections. Despite evidence that environmental oxidant pollutants, such as ozone, may increase the severity of viral disease, the mechanisms underlying such an effect have not been identified. This study will test the hypothesis that exposure of allergic asthmatic subjects to ambient levels of ozone directly enhances viral disease by increasing infectivity and intensifying virus-induced inflammation.
Details: In mild asthmatics, the study will investigate: (1) if exposure to ozone will enhance the viral infective process in the nasal epithelium, (2) the effect of ozone exposure on RV-induced inflammatory gene expression, mediator release and inflammatory cell influx into the upper and lower airways, and (3) the interactive effects of ozone and RV on airway reactivity. This information will improve our understanding of the risk associated with oxidant pollutant exposure in this population of individuals in whom RV infection may represent a significant health concern.
Eligibility:
Study Type: Observational, Screening, Cross-Sectional, Defined Population, Prospective Study
Minimum Age/Maximum Age: 18 Years/45 Years
Genders: Both
Protocol Entry Criteria: Subjects recruited will be non-asthmatic controls or mild allergic asthmatics using beta-agonists, mostly on an "as needed" basis. Selection criteria will include good general health by medical history and physical examination, no history of smoking, and the absence of respiratory infection in the preceding 6 week period. Subjects will undergo serologic testing and must have a negative test for neutralizing antibodies to RV16 to participate in all but one study of the project.
Total Enrollment: 60
Location and Contact Information:
The Johns Hopkins School of Hygiene and Public Health *Recruiting*
Baltimore, Maryland, 21205
United States
Recruiting Kris Macri 410-955-2515
Additional Information:
Study ID Numbers: 9004-CP-001;
Study Start Date: September 1999
Record last reviewed: March 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00013715
Other Asthma Studies:
1. Strong Heart Study
2. Isocyanate Antigens and T Cells That Cause Asthma
3. Childhood Asthma Program in NYC Health Department Clinics
4. Segmental Bronchoalveolar Lavage
5. Characterizing a 5P-Linked BHR Susceptibility Locus
Related Studies:
Other Asthma Clinical Trials
Other Maryland Clinical Trials
Other Baltimore Clinical Trials
Ozone and Rhinovirus-Induced Disease in Asthmatics
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