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Nutritional Aspects of Rett Syndrome



Nutritional Aspects of Rett Syndrome

For Condition: Rett Syndrome
Status: Completed
Sponsor(s): National Institute of Child Health and Human Development (NICHD) , Baylor College of Medicine
Synopsis: OBJECTIVES: I. Determine dietary macronutrient intake in children with Rett syndrome and in healthy controls. II. Measure sleeping and awake metabolic rates in various positions, i.e., reclining, sitting, and standing, by whole-room indirect calorimetry and isotope dilution. III. Quantify activity patterns by time-motion studies using 24-hour activity records and 12-hour videotaping. IV. Correlate 24-hour activity patterns with 24-hour heart rate telemetry and short-term oxygen consumption. V. Estimate 24-hour fecal and urinary energy losses. VI. Determine body composition by clinical anthropometry, whole-body potassium counting, and total-body electrical conductance. VII. Calculate apparent energy needs based on measurement of energy intake and expenditure.
Details: PROTOCOL OUTLINE: All participants undergo extensive nutritional and metabolic assessment with body composition evaluation. Studies include macronutrient intake, body fat, lean muscle mass, metabolic rate, and time-action studies; and 24-hour cardiac telemetry. Rett syndrome girls also receive a hemogram and hand x-ray.
Eligibility:
Study Type:
  Interventional, Diagnostic
Minimum Age/Maximum Age: 5 Years/18 Years
Genders: Female
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: Patients aged 5 to 18 with Rett syndrome Able to sleep and awaken alone
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
KathleenMotil,  Study Chair,  Baylor College of Medicine


Additional Information:
Study ID Numbers:
  199/11814;  BCM-CNRC-H1637
Study Start Date: May 1993
Record last reviewed: February 1999
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004656

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2. Study of the Pathogenesis of Rett Syndrome

3. Dextromethorphan and Donepezil Hydrochloride for Rett Syndrome

4. Study of Cardiac and Paroxysmal Abnormalities in Rett Syndrome

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