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Home > "N" Clinical Trials Conditions > Neuropsychiatric Evaluation of Healthy Volunteers and Adults with Schizophrenia  Neuropsychiatric Evaluation of Healthy Volunteers and Adults with Schizophrenia
Neuropsychiatric Evaluation of Healthy Volunteers and Adults with Schizophrenia
For Condition: Brain Injury,Dementia,Healthy,Mental Disorder,Schizophrenia
Status: Recruiting
Sponsor(s): National Institute of Mental Health (NIMH) ,
Synopsis: The purpose of this study is to evaluate the cognitive processes of participants with schizophrenia, participants with nervous system and mental disorders, and healthy volunteers. Participants in this study will undergo cognitive tests of attention, memory, attention. Participants with attention deficit hyperactivity disorder (ADHD), traumatic brain injury (TBI), bipolar disorder, and Alzheimer's disease (AD) will be compared with participants with schizophrenia. A group of healthy adults and children will undergo cognitive tests to further delineate the degree of impairment in schizophrenia and neurological disorder participants.
Details: In this study, we propose to administer cognitive tests to schizophrenic patients and to neurologic patients who will serve as contrast groups for neuropsychological studies of patients with schizophrenia. These include studies of Alzheimers disease to dissociate size and organization of lexicon and ADHD and error patterns on CPT. However, the majority of studies will examine schizophrenia in relation to normal controls. In addition, we propose to obtain test results from a local sample of normal subjects of varying ages and educational backgrounds to further delineate degree of impairment in these clinical groups. As well as assessing adults we wish to assess normal children. In particular, we wish to identify in children the size of their lexicon and their degree of semantic organization within their lexicon.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA English-speaking adults between ages 21 to 65, in good health and free from significant substance abuse. Children between ages 4 to 20 must not have a history of special education, using psychotropic medication in long-term counseling or with a history of seizures, head injury or CNS infections. Normal controls will be recruited and screened for exclusionary morbidity by interview (e.g., no history of contact with mental health professionals, no history of diagnosable alcohol and/or substance abuse). Normal controls will be recruited from building employees, local universities, from NIMH rosters, and the general public. EXCLUSION CRITERIA Excluded are adults with histories of dementing illness, movement disorder, affective disorders, developmental and/or acquired brain injury. Diagnoses will be made by review of medical records, interview, examination, and in the case of psychiatric diagnoses, a structured interview by SCID. Advertisement will make clear that the subjects will be asked questions about family psychiatric history and their own history or psychiatric disorder, substance abuse, and neurological disease. Only if the subject answers these negatively will he or she participate in this study.
Total Enrollment: 810
Location and Contact Information:
National Institute of Mental Health (NIMH) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Terry Goldberg 3014027810
Additional Information:
Study ID Numbers: 920262; 92-M-0262
Study Start Date: August 25, 1992
Record last reviewed: October 22, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001323
Other Brain Injury Studies:
1. Neuropsychiatric Evaluation of Healthy Volunteers and Adults with Schizophrenia
2. Study of the Approximate Entropy of Adrenocorticotropic Hormone and Cortisol Secretion in Patients With Head Injury
3. Genotype Influence on Recovery After Traumatic Brain Injury
4. Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage
5. Phase I/II Study of Neuroendocrine Dysfunction in Patients With Closed Head Injuries
Related Studies:
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Neuropsychiatric Evaluation of Healthy Volunteers and Adults with Schizophrenia
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