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Home > "N" Clinical Trials Conditions > Natural History of Patients with Brain and Spinal Cord Tumors  Natural History of Patients with Brain and Spinal Cord Tumors
Natural History of Patients with Brain and Spinal Cord Tumors
For Condition: Glioblastoma,Central Nervous System Tumor,Glioma,Medulloblastoma,Astrocytoma
Status: Recruiting
Sponsor(s): National Cancer Institute (NCI) ,
Synopsis: This study offers evaluation of patients with brain and spinal cord tumors. Its purpose is threefold: 1) to allow physicians in NIH's Neuro-Oncology Branch to increase their knowledge of the course of central nervous system tumors and identify areas that need further research; 2) to inform participants of new studies at the National Cancer Institute and other centers as they are developed; and 3) to provide patients consultation on possible treatment options. Children (at least 1 year old) and adults with primary malignant brain and spinal cord tumors may be eligible for this study. Participants will have a medical history, physical and neurological examinations and routine blood tests. They may also undergo one or more of the following procedures: -Magnetic resonance imaging (MRI) - MRI is a diagnostic tool that uses a strong magnetic field and radio waves instead of X-rays to show detailed changes in brain structure and chemistry. For the procedure, the patient lies on a table in a narrow cylinder containing a magnetic field. A contrast material called gadolinium may be used (injected into a vein) to enhance the images. The procedure takes about an hour, and the patient can speak with a staff member via an intercom system at all times. -Computed axial tomography (CAT or CT) - CT is a specialized form of X-ray imaging that produces 3-dimensional images of the brain in sections. The scanner is a ring device that surrounds the patient and contains a moveable X-ray source. The scan takes about 30 minutes and may be done with or without the use of a contrast dye. -Positron emission tomography (PET) - PET is a diagnostic test that is based on differences in how cells take up and use glucose (sugar), one of the body's main fuels. The patient is given an injection of radioactive glucose. A special camera surrounding the patient detects the radiation emitted by the radioactive material and produces images that show how much glucose is being used by various tissues. Fast-growing cells, such as tumors, take up and use more glucose than normal cells do, and therefore, the scan might indicate the overall activity or aggressiveness of the tumor. The procedure takes about an hour. When all the tests are completed, the physician will discuss the results and potential treatment options with the patient. Follow-up will vary according to the individual. Some patients may end the study with just one visit to NIH, while others may be followed at NIH regularly, in conjunction with their local physicians. Patients with aggressive tumors may be seen every 3 or 4 months, while those with less active tumors may be seen every 6 to 12 months. Permission may be requested for telephone follow-up (with the patient or physician) of patients not seen regularly at NIH.
Details: This protocol is designed to evaluate patients with tumors of the central nervous system (CNS) who appear to be probable candidates for future protocol entry or have disease manifestations that are of unique scientific interest, importance, and/or educational value.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: All patients greater than or equal to 12 months of age with tumors of the CNS of interest to the NOB, who are not immediately eligible for another ongoing NOB protocol, but who may be candidates at some point in the future. Patients with tumors of the CNS that are of particular interest to members of the NOB because they pose important clinical and/or scientific questions and/or shed light on important aspects of the disease. Patients with tumors of the CNS who offer an important educational benefit to neuro-oncology trainees and staff. Ability for adult patients or individuals granted Durable Power of Attorney (DPA) to give informed consent. Availability of a parent or legal guardian to give informed consent for children. EXCLUSION CRITERIA: Patients less than 12 months of age. Patients who are eligible for other NOB protocols.
Total Enrollment: 600
Location and Contact Information:
National Cancer Institute (NCI) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Clinical Support Center/NCI 1-888-624-1937
Additional Information:
Study ID Numbers: 010070; 01-C-0070
Study Start Date: January 19, 2001
Record last reviewed: January 1, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00009035
Other Glioblastoma Studies:
1. A Study of Motexafin Gadolinium and Temozolomide for the Treatment of Malignant Gliomas
2. Phase I trial of CC-8490 for the treatment of subjects with recurrent/refractory high-grade gliomas
3. Temozolomide in Treating Adults With Newly Diagnosed Primary Malignant Glioblastoma Multiforme
4. Natural History of Patients with Brain and Spinal Cord Tumors
5. Detecting Malignant Brain Tumor Cells in the Bloodstream During Surgery to Remove the Tumor
Related Studies:
Other Glioblastoma Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Natural History of Patients with Brain and Spinal Cord Tumors
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