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Home > "N" Clinical Trials Conditions > National Marrow Donor Program (NMDP)  National Marrow Donor Program (NMDP)
National Marrow Donor Program (NMDP)
For Condition: Bone Marrow Transplantation
Status: Completed
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: To serve as a focal point for bone-marrow research.
Details: BACKGROUND: In 1986, the Department of the Navy initiated the National Bone Marrow Donor Registry. Because the support of a National Bone Marrow Donor Registry was not very closely related to the Navy's primary missions, in 1989 the management of the contract for the program was transferred by the Congress from the Navy to the NHLBI. By 1989, bone marrow transplantation had become an effective and accepted treatment for an increasing number of diseases of the bone marrow and the immune system. Until only a few years prior to 1989, most marrow donors were siblings, carefully matched for HLA (tissue) antigens. Since only a small proportion of candidates for a bone marrow transplant have matched brothers or sisters, additional family members were tried as donors. These included parents, children, slightly mismatched siblings, and other relatives. Even with the broadening of the bone marrow donor source, no more than 30-40 percent of patients with diseases amenable to marrow transplant therapy had available donors. Improved results with these selectively mismatched relatives and a distinct need to provide appropriate treatment for more patients led to trials with unrelated, HLA-matched community volunteers as bone marrow donors. By 1989, research had progressed to the point where transplants from such unrelated donors were nearly as successful as those from matched siblings, when stratified by disease status and risk parameters. In 1989, 20 to 25 percent of patients for whom a formal donor search was initiated received a transplant. This was expected to increase substantially. DESIGN NARRATIVE: The program was established by the Department of the Navy in 1986 and transferred to the NHLBI in 1989. The purpose was to develop and maintain a registry of individuals willing to donate bone marrow for patients in need of transplants, to faciliate marrow transplants by serving as a coordinating and communications center for a network of donor, collection and transplant centers in the United States and internationally, and to facilitate research into the efficacy of unrelated donor marrow transplants. In 1992, the program was enlarged to support a limited number of demonstration projects to develop, implement, and evaluate innovative models for minority marrow donor recruitment. In 1995, the NMDP was transferred to the Health Resources and Services Administration (HRSA), although NHLBI provided funds in this year.
Eligibility:
Study Type: Observational, Screening
Minimum Age/Maximum Age: /
Genders: Male
Protocol Entry Criteria: No eligibility criteria
Total Enrollment:
Location and Contact Information:
Overall Study Official:
CraigHowe, ,
Additional Information:
Study ID Numbers: 4939;
Study Start Date: January 1989
Record last reviewed: August 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00005730
Other Bone Marrow Transplantation Studies:
1. The Effects of Music Therapy-Based Stress Reduction on Bone Marrow Transplant Recipients
2. Reducing the Risk of Transplant Rejection: Simultaneous Kidney and Bone Marrow Transplant
3. Sibling Donor Cord Blood Banking and Transplantation
4. T-Cell Depletion in Unrelated Donor Marrow Transplantation
5. Blood and Marrow Transplant Clinical Research Network
Related Studies:
Other Bone Marrow Transplantation Clinical Trials
Other Clinical Trials
Other Clinical Trials
National Marrow Donor Program (NMDP)
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