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Home > "N" Clinical Trials Conditions > National Lung Screening Trial (NLST)  National Lung Screening Trial (NLST)
National Lung Screening Trial (NLST)
For Condition: Small Cell Lung Cancer,Non-small cell lung cancer
Status: No longer recruiting
Sponsor(s): National Cancer Institute (NCI) , American College of Radiology Imaging Network
Synopsis: RATIONALE: Screening tests may help doctors detect cancer cells early and plan more effective treatment for lung cancer. It is not yet known whether helical CT scan is more effective than chest x-ray in reducing death from lung cancer. PURPOSE: Randomized clinical trial to compare the effectiveness of helical CT scan with that of chest x-ray in screening individuals who are at high risk for developing lung cancer.
Details: OBJECTIVES: - Compare whether screening with low-dose helical CT scan vs chest x-ray reduces lung cancer-specific mortality in participants who are at high risk for developing lung cancer. OUTLINE: This is a randomized, multicenter study. Participants are randomized to 1 of 2 screening arms. - Arm I: Participants undergo helical CT scan. - Arm II: Participants undergo chest x-ray. Participants in both arms undergo screening initially and then annually for 2 years. Participants will then be contacted annually by mail or telephone for several years. The National Lung Screening Trial (NLST) represents the union of two NCI-sponsored activities, the NCI Lung Screening Study I and the American College of Radiology Imaging Network (ACRIN). For more information, please access the ACRIN trial on Cancer.gov. The protocol ID is ACRIN-6654. PROJECTED ACCRUAL: A total of 50,000 participants will be accrued for this study within 2 years.
Eligibility:
Study Type: Observational, Screening
Minimum Age/Maximum Age: 55 Years/74 Years
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Heavy smoker or former smoker (quit within last 15 years) - No prior cancer (other than nonmelanoma skin cancer or in situ cancer) within past 5 years PATIENT CHARACTERISTICS: Age - 55 to 74 Performance status - Not specified Life expectancy - Not specified Hematopoietic - Not specified Hepatic - Not specified Renal - Not specified PRIOR CONCURRENT THERAPY: Biologic therapy - Not specified Chemotherapy - Not specified Endocrine therapy - Not specified Radiotherapy - Not specified Surgery - Not specified
Total Enrollment:
Location and Contact Information:
Overall Study Official:
DeniseAberle, Principal Investigator, Jonsson Comprehensive Cancer Center
University of Alabama at Birmingham Comprehensive Cancer Center
Birmingham, Alabama, 35233
United States
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, 21231
United States
Georgetown University Medical Center
Washington D.C., District of Columbia, 20007
United States
Abramson Cancer Center at University of Pennsylvania Medical Center
Philadelphia, Pennsylvania, 19104
United States
Duke Comprehensive Cancer Center
Durham, North Carolina, 27710
United States
Josephine Ford Cancer Center at Henry Ford Hospital
Detroit, Michigan, 48202
United States
University of Iowa
Iowa City, Iowa, 52242-1011
United States
Mayo Clinic
Jacksonville, Florida, 32224
United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109-0942
United States
Hillman Cancer Center at University of Pittsburgh Cancer Institute
Pittsburgh, Pennsylvania, 15236
United States
Rebecca and John Moores UCSD Cancer Center
La Jolla, California, 92093-0658
United States
Mountain States Tumor Institute - Boise
Boise, Idaho, 83712
United States
Jewish Heart and Lung Institute
Louisville, Kentucky, 40202
United States
Ochsner Clinic Foundation
New Orleans, Louisiana, 70121
United States
Huntsman Cancer Institute
Salt Lake City, Utah, 84112
United States
Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center
Nashville, Tennessee, 37232-6838
United States
Brigham and Women's Hospital
Boston, Massachusetts, 02115
United States
Norris Cotton Cancer Center at Dartmouth Medical School
Lebanon, New Hampshire, 03756-0002
United States
Mallinckrodt Institute of Radiology
St. Louis, Missouri, 63108
United States
Roger Williams Medical Center
Providence, Rhode Island, 02908-4735
United States
Hollings Cancer Center at Medical University of South Carolina
Charleston, South Carolina, 29425
United States
Emory University School of Medicine
Atlanta, Georgia, 30322
United States
University of Minnesota Cancer Center
Minneapolis, Minnesota, 55455
United States
Alton Ochsner Medical Foundation Hospital
New Orleans, Louisiana, 70121
United States
Jewish Hospital
Louisville, Kentucky, 40202-1886
United States
University of Colorado Cancer Center at University of Colorado Health Sciences Center
Denver, Colorado, 80262
United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215
United States
Mayo Clinic Cancer Center
Rochester, Minnesota, 55905
United States
St. Elizabeth Cancer Center at St. Elizabeth Health Center - Youngstown
Youngstown, Ohio, 44501
United States
CCOP - Marshfield Clinic Research Foundation
Marshfield, Wisconsin, 54449
United States
Jonsson Comprehensive Cancer Center, UCLA
Los Angeles, California, 90095-1781
United States
Comprehensive Cancer Center at Wake Forest University
Winston Salem, North Carolina, 27157-1082
United States
Cancer Institute of New Jersey at Hamilton
Hamilton, New Jersey, 08690
United States
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, 33612-9497
United States
Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Chicago, Illinois, 60611
United States
Pacific Health Research Institute
Honolulu, Hawaii, 96813
United States
University of Texas - MD Anderson Cancer Center
Houston, Texas, 77030-4009
United States
Additional Information:
Study ID Numbers: CDR0000257938; NCI-NLST,ACRIN-NCI-NLST
Study Start Date:
Record last reviewed: April 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00047385
Other Small Cell Lung Cancer Studies:
1. Chest X-ray or Chest CT Scan in Patients at High Risk of Developing Lung Cancer
2. National Lung Screening Trial (NLST)
3. Celecoxib in Preventing Lung Cancer in Former Heavy Smokers
4. Radiofrequency Ablation in Treating Patients With Refractory or Advanced Lung Cancer
5. Inositol in Preventing Lung Cancer in Patients With Bronchial Epithelial Dysplasia Who Are Current or Former Smokers
Related Studies:
Other Small Cell Lung Cancer Clinical Trials
Other Michigan Clinical Trials
Other Ann Arbor Clinical Trials
National Lung Screening Trial (NLST)
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