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MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery Clinical Trials Resources presented on Clinical Trials Search is not meant to be a substitute for proven health advice, calls or treatment with a real medical. We aren't mDs. Always consult your doctor on MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery Clinical research trials and MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery healthcare trials take place in a lot of of localities throughout the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically assess the effectiveness of new does drugs. The function of the studies / projects is to figure out specific human medical questions. Clinical trials are a popular means for doctors, government agencies, and private sector corporations to find cures for all varieties of conditions, like MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery. MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery Clinical Trials and other clinical trials allow volunteers to access health treatment options before they are available to the masses. Many times the subjects receive professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery clinical trial. Human subjects often obtain the finest healthcare possible for their MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery condition. Hazards are a reality, nevertheless, and might include additional or frequent dr. calls, health hazards (potentially life-jeopardizing), and/or the treatment being uneffective. Trials are federally regulated with stern guidelines to protect clinical trials patients.
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Home > "M" Clinical Trials Conditions > MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery  MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery
MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery
For Condition: Renal Artery Obstruction,Kidney Disease
Status: Recruiting
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: This study will use magnetic resonance imaging (MRI) to picture the kidney and renal arteries (arteries that supply blood to the kidney) in patients scheduled for kidney artery angiogram and angioplasty/stenting procedures. An angiogram is a way of taking pictures of arteries that shows areas of narrowing caused by atherosclerosis-a buildup of plaque on the vessel wall. Angioplasty/stent is a treatment procedure in which a balloon-tipped catheter is inserted in the artery and advanced to the area of blockage to open the vessel, increasing blood flow to the kidney. A permanent metal tube (stent) may or may not be put in place to maintain the opening. During either of these invasive procedures, small pieces of plaque can break off and travel in the blood to lodge elsewhere in the body. This is called embolization. Lodged in the kidney, the embolus can impair kidney function. Currently, these emboli cannot be detected. A new way of visualizing the kidneys that allows detection of emboli may reveal whether material has moved to the kidneys and predict if there will be any kidney damage. Patients 21 years of age and older with suspected kidney artery disease scheduled for invasive angiographic evaluation in NIH protocol 95-H-0047 may be eligible for this study. Participants will be assigned to one of two study groups, based on the angiogram findings and the decision to have the angioplasty/stent procedure. Participants in both groups will have baseline MRI scans up to 2 weeks before the invasive procedure (angiogram with or without angioplasty/stent) and again within a day after the procedure. Patients who undergo angioplasty/stent will have another MRI study within about a month following the procedure. MRI uses a magnetic field and radio waves to produce images of body tissues. The patient lies on a table that slides into a large hollow tube (the scanner). During part of the scan, a material called gadolinium contrast may be injected into a vein. This substance brightens the images to better show the kidneys, their blood vessels and blood flow. The procedure lasts from about 1 to 2 hours. During the MRI, the heart is monitored with an electrocardiogram (EKG) and breathing is monitored with a flexible belt. Blood pressure is measured intermittently. The patient can communicate with a staff member at all times. Blood samples will be drawn from an arm vein at the initial clinic visit, within a day after the procedure and about 1 week after the procedure. For patients who had the angioplasty/stent procedure, a third blood sample will be taken within another 6 six weeks. The blood samples will be used to check for changes in kidney function.
Details: Atherosclerotic renal artery stenosis (ARAS) is common and is associated with uncontrolled hypertension and renal excretory dysfunction. Percutaneous stenting of ARAS effectively relieves arterial obstruction, but approximately one-quarter of patients derives no apparent clinical benefit or actually suffers deterioration in renal excretory function. There are reasons to suspect that percutaneous renal intervention is associated with embolization of aorto-ostial atheromatous debris, which may lead to adverse clinical outcomes. There are no known clinical, imaging, or biochemical markers of renal embolism or ischemic necrosis. Investigational or clinical detection of such events might guide future modification of mechanical interventional technique, for example, with the introduction of procedural embolic protection devices. This pilot study of patients undergoing percutaneous transluminal renal artery stenting (PTRAS) will attempt to image embolization using magnetic resonance imaging (MRI).
Eligibility:
Study Type: Interventional, Treatment, Safety
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Adult patients with clinically suspected renovascular disease undergoing invasive angiographic assessment in protocol 95-H-0047 at the NIH CC. Adult patients with clinically suspected renovascular disease undergoing invasive angiographic assessment at other medical centers. EXCLUSION CRITERIA - Contraindications to MRI: Cardiac pacemaker or implantable defibrillator Cerebral aneurysm clip Neural stimulator (e.g. TENS-Unit) Any type of ear implant Metal in eye (e.g. from machining) Any implanted device (e.g. insulin pump, drug infusion device) Known hypersensitivity to gadolinium contrast agents EXCLUSION CRITERIA - General: Patients less than 21 years old Pregnant or lactating women
Total Enrollment: 60
Location and Contact Information:
National Heart, Lung and Blood Institute (NHLBI) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 020059; 02-H-0059
Study Start Date: December 4, 2001
Record last reviewed: December 10, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00027469
Other Renal Artery Obstruction Studies:
1. Living-Related Donor Bone Marrow Immunoregulation in Kidney Transplants
2. Monitoring for Tolerance to Kidney or Combined Kidney-Pancreas Transplants
3. MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery
4. Angiotensin-Converting Enzyme Gene Polymorphism and the Risk of Chronic Allograft Nephropathy
5. Effectiveness of the Investigational Drug Campath-1H in Preventing Rejection of Transplanted Kidneys
Related Studies:
Other Renal Artery Obstruction Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery
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