|
Motor Learning in Stroke Patients and Healthy Volunteers Clinical Trials Information presented on Clinical Trials Search isn't intended to be a substitute for proven healthcare advice, trips or treatment using a real physician. We are not docs. Always confer with your mD on Motor Learning in Stroke Patients and Healthy Volunteers conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Motor Learning in Stroke Patients and Healthy Volunteers Clinical research trials and Motor Learning in Stroke Patients and Healthy Volunteers medical trials take place in hundreds of localities across the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually measure the effectiveness of new drugs. The intention of the studies / projects is to resolve certain human health questions. Clinical trials are a popular means for physicians, government agencies, and private sector corporations to detect remedies for all forms of circumstances, like Motor Learning in Stroke Patients and Healthy Volunteers. Motor Learning in Stroke Patients and Healthy Volunteers Clinical Trials and other clinical trials allow for volunteers to undergo healthcare treatment options before they are available to the masses. Most times the participants receive treatment for free, and every now and again they are paid for their time. Occasionally there is a cost for a Motor Learning in Stroke Patients and Healthy Volunteers clinical trial. Subjects typically recieve the finest healthcare available for their Motor Learning in Stroke Patients and Healthy Volunteers condition. Hazards are a reality, nonetheless, and might include more or frequent mD trips, health risks (potentially life-endangering), and/or the treatment being ineffective. Trials are federally regulated with stern guidelines to protect clinical trials subjects.
|
|
|
|
|
|
|
Home > "M" Clinical Trials Conditions > Motor Learning in Stroke Patients and Healthy Volunteers  Motor Learning in Stroke Patients and Healthy Volunteers
Motor Learning in Stroke Patients and Healthy Volunteers
For Condition: Healthy,Stroke
Status: Recruiting
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) ,
Synopsis: This study will try to elucidate learning processes associated with motor training in the weak arm of stroke patients compared with healthy controls. Results from previous clinical trials indicate that training may enhance motor function in healthy volunteers, and perhaps also in stroke patients, even more than 1 year after the stroke. Normal, healthy volunteers and stroke patients 18 years of age and older may be eligible for this study. Study subjects will have a physical examination and participate in 6 additional clinic visits-training and testing sessions on study days 1, 2, 3, 4 and 5, and a final testing session on day 12. During these sessions, they will perform a series of motor tasks, including writing, picking up objects, turning cards, stacking checkers and moving cans, which will be timed and videotaped. Each session will be divided into blocks of 10 trials for each task, separated by 2-minute rest periods. Before and after training on days 1, 2, 5 and 12, subjects will have transcranial magnetic stimulation (TMS) to determine brain changes associated with learning a motor task. For this procedure, the patient is seated in a comfortable chair, and an insulated wire coil is placed on the scalp or skin. A brief electrical current is passed through the coil, creating a magnetic pulse that stimulates the brain. These pulses generate very small electrical currents in the brain cortex, briefly disrupting the function of the brain cells in the stimulated area. The stimulation may cause muscle twitching or tingling in the scalp, face, or limb. During the stimulation, the subject may be asked to slightly tense certain muscles or perform other simple actions. Electrical nerve stimulation and electromyography will be done to record muscle responses to stimulation. A nerve is stimulated by placing wires on the skin over the nerve and passing a brief electrical current between the wires. Electromyography involves taping metal electrodes to the skin over the muscle. Before and after each session, subjects' muscle strength will be tested with a pinch gauge. They will also be asked to make a mark on a line drawn on paper, to rate their test performance and levels of attentiveness and fatigue.
Details: The purpose of this protocol is to characterize dynamics of motor learning over a 5-day period in chronic stroke patients relative to healthy age-matched controls. Motor learning will be assessed by improvements in the Jebsen-Taylor test, a validated tool widely used in rehabilitation that measures upper extremity function. Additionally, we intend to evaluate changes in the excitability of the primary motor cortex associated with learning using transcranial magnetic stimulation.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA FOR HEALTHY VOLUNTEERS Age: 18 years to 100 years Normal physical and neurological examinations EXCLUSION CRITERIA FOR HEALTHY VOLUNTEERS Contraindications for transcranial magnetic stimulation: pacemaker, implanted medical pump, metal plate in skull, metal objects inside the eye or skull, history of seizures INCLUSION CRITERIA FOR STROKE PATIENTS Age: 18 years to 100 years Single ischemic or hemorrhagic hemispheric stroke at least one year before enrollment in study, confirmed by neuroimaging studies (computerized tomography or magnetic resonance imaging). Ability to perform the Jebsen-Taylor test. EXCLUSION CRITERIA FOR STROKE PATIENTS More than one stroke. Other brain lesions (i.e., traumatic brain injury, brain tumor) or neurological problems (i.e., multiple sclerosis, dementia, Parkinson's disease) Depression or poor motivational capacity Serious cognitive deficits (defined as equivalent to a mini-mental state exam score of 20 or less). Inability to understand instructions for the Jebsen-Taylor test. Uncontrolled medical problems including cardiovascular disease, severe rheumatoid arthritis, active joint deformity of arthritic origin, active cancer or renal disease, any kind of end-stage pulmonary or cardiovascular disease, uncontrolled epilepsy Contraindications for transcranial magnetic stimulation: pacemaker, implanted medical pump, metal plate in skull, metal objects inside the eye or skull, history of seizures
Total Enrollment: 78
Location and Contact Information:
National Institute of Neurological Disorders and Stroke (NINDS) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 010220; 01-N-0220
Study Start Date: July 30, 2001
Record last reviewed: July 16, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00021710
Other Stroke Studies:
1. Human Movement Database
2. Stem Cell Collection for Adult Volunteers
3. Effect of Hydrocortisone on the Brain
4. Hormone Replacement in Young Women with Premature Ovarian Failure
5. Magnetic Resonance Imaging for Evaluating Kidney Function
Related Studies:
Other Stroke Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Motor Learning in Stroke Patients and Healthy Volunteers
|
|
|
|
|
|
|
|
