Search Clinical Trials
By Condition
By Location (USA)
By Location (Other)
By Sponsor
Resources
Privacy Policy
About Us
Disclaimer
Molecular & Clinical Evaluation of Low HDL Syndromes Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for qualified medical advice, visits or professional assistance by using a real mD. We are not docs. Always confer with your physician about Molecular & Clinical Evaluation of Low HDL Syndromes conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Molecular & Clinical Evaluation of Low HDL Syndromes Clinical research trials and Molecular & Clinical Evaluation of Low HDL Syndromes health trials occur in many of cities throughout the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the effectivity of new does drugs. The intent of the studies / undertakings is to resolve particular human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to detect remedies for all sorts of conditions, including Molecular & Clinical Evaluation of Low HDL Syndromes. Molecular & Clinical Evaluation of Low HDL Syndromes Clinical Trials and other clinical trials permit volunteers to obtain healthcare treatment alternatives before they are available to the masses. Most times the participants undergo professional assistance for without cost, and occasionally they are compensated for their time. Occasionally there is a cost for a Molecular & Clinical Evaluation of Low HDL Syndromes clinical trial. Test subjects typically receive the most expert healthcare available for their Molecular & Clinical Evaluation of Low HDL Syndromes condition. Dangers are a reality, however, and may include more or frequent mD visits, healthcare dangers (perhaps life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with rigid guidelines to protect clinical trials patients.

Home > "M" Clinical Trials Conditions > Molecular & Clinical Evaluation of Low HDL Syndromes

Molecular & Clinical Evaluation of Low HDL Syndromes



Molecular & Clinical Evaluation of Low HDL Syndromes

For Condition: Atherosclerosis,Heart Diseases,Cardiovascular Diseases
Status: No longer recruiting
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: To study the genetic cause of low HDL-C, a risk factor for premature atherosclerotic vascular disease in patients with normal total cholesterol. The focus is primarily on the identification of a single mutation, as has been demonstrated in one family.
Details: BACKGROUND: Low levels of high density lipoprotein cholesterol (HDL-C) have been found to be associated with an increased risk for coronary artery disease (CAD). However, the genetic basis for this association is not well understood and the clinical implications of this association have not been extensively addressed. The study, in seeking to elucidate the genetic basis for low HDL-C and examine the clinical implications of low HDL-C, focuses upon an important research topic. DESIGN NARRATIVE: Specific aims of the study include: 1) Collection and characterization of plasma and DNA from probands with very low HDL-C. Linkage analysis will be performed using highly polymorphic markers within or near HDL-C candidate genes. The hypothesis to be tested is that polymorphic microsatellites segregate with the low HDL-C phenotype. 2) Further genetic characterization of families evidence of linkage to specific HDL-C candidate genes identified in Specific Aim 1. The hypothesis to be tested is that structural variants in HDL-C candidates are responsible for low HDL-C. 3) Evaluate the physiologic significance of novel genomic variants identified in Specific Aim 2. The hypothesis to be tested is that structural variants will affect expression of the gene product. 4) Examine early atherosclerosis in low HDL-C syndromes. The hypothesis to be tested is that increased carotid intima-medial thickness is prevalent with isolated low HDL-C.
Eligibility:
Study Type:
  Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Male
Protocol Entry Criteria: No eligibility criteria
Total Enrollment: 

Location and Contact Information:


Additional Information:
Study ID Numbers:
  912; 
Study Start Date: August 2000
Record last reviewed: February 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00006295

Other Atherosclerosis Studies:
1. Seasonal Variation of Blood Cholesterol Levels

2. Epidemiology of Coronary Heart Disease in Men Aged 40 and Over

3. Postprandial Lipemia and Endothelial Function in ACCORD- Ancillary to ACCORD

4. Effects of Hormone Therapy on the Immune Systems of Postmenopausal Women with Chronic Infections

5. Assessment of a B-Mode Ultrasound Technique for the Measurement of Carotid Artery Intima-Media Thickness

Related Studies:

Other Atherosclerosis Clinical Trials
Other Clinical Trials
Other Clinical Trials

Molecular & Clinical Evaluation of Low HDL Syndromes

Modify your Search

  Other Atherosclerosis Clinical Trials
  Other Clinical Trials
  Other Clinical Trials


Warning: include(/var/www/cgi-bin/traxis/counter.php) [function.include]: failed to open stream: No such file or directory in /home/cts/domains/clinicaltrialssearch.org/public_html/index.php on line 103

Warning: include() [function.include]: Failed opening '/var/www/cgi-bin/traxis/counter.php' for inclusion (include_path='.:/usr/local/lib/php') in /home/cts/domains/clinicaltrialssearch.org/public_html/index.php on line 103