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Home > "M" Clinical Trials Conditions > Metabolic Abnormalities in Children with Epilepsy  Metabolic Abnormalities in Children with Epilepsy
Metabolic Abnormalities in Children with Epilepsy
For Condition: Generalized Epilepsy,Infantile Spasms,Metabolic Disease,Partial Epilepsy,Seizures
Status: No longer recruiting
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) ,
Synopsis: This study is designed to use positron emission tomography to measure brain energy use. Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal processes of the brain (central nervous system) of normal individuals and patients with neurologic illnesses without physical / structural damage to the brain. When a region of the brain is active, it uses more fuel in the form of oxygen and sugar (glucose). As the brain uses more fuel it produces more waste products, carbon dioxide and water. Blood carries fuel to the brain and waste products away from the brain. As brain activity increases blood flow to and from the area of activity increases also. Researchers can label a sugar with a small radioactive molecule called FDG (fluorodeoxyglucose). As areas of the brain use more sugar the PET scan will detect the FDG and show the areas of the brain that are active. By using this technique researchers hope to answer the following questions; 4. Are changes in brain energy use (metabolism) present early in the course of epilepsy 5. Do changes in brain metabolism match the severity of patient's seizures 6. Do changes in metabolism occur over time or in response to drug therapy
Details: We propose to study children with recent onset partial epilepsy, cryptogenic infantile spasms, and idiopathic Lennox-Gastaut Syndrome with serial FDG-PET to elucidate the natural history and evolution of metabolic abnormalities associated with such epilepsies. The severity of the seizure disorder, and cognitive impairment, when present, will be correlated with the presence and extent of focal and global cerebral metabolic abnormalities.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Patients with partial seizures, infantile spasms and Lennox-Gastaut syndrome will be selected. EXCLUSION CRITERIA: Evidence of a structural lesion as cause for epilepsy. Degenerative or metabolic disease. Inability to comply with the protocol.
Total Enrollment: 80
Location and Contact Information:
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 920175; 92-N-0175
Study Start Date: April 25, 1992
Record last reviewed: April 14, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001325
Other Infantile Spasms Studies:
1. Safety and Efficacy of Xenical in Children and Adolescents with Obesity-Related Diseases
2. Studies of Children with Metabolic and Other Genetic Disorders
3. Metabolic Abnormalities in Children with Epilepsy
Related Studies:
Other Infantile Spasms Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Metabolic Abnormalities in Children with Epilepsy
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