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Medication Treatment for Depression in Nursing Home Residents



Medication Treatment for Depression in Nursing Home Residents

For Condition: Depression
Status: Recruiting
Sponsor(s): National Institute of Mental Health (NIMH) ,
Synopsis: The purpose of this study is to examine the effects of continuing antidepressant medication in nursing home residents who no longer have depressive symptoms. The usefulness of continuing maintenance treatment for depression will be determined.
Details: There are approximately 1.6 million nursing home residents in the United States. More than one third of these residents are taking antidepressant medications (ADs). Although ADs are effective, evidence suggests that they can lead to significant adverse events, including an increased risk of bone fractures and impairments of the nervous system which increase the risk of dangerous falls. Many depressed nursing home residents suffer from an initial episode of late life depression and do not meet guideline-based recommendations for maintenance treatment. This study will examine the benefits and risks of long-term AD treatment in depressed nursing home residents whose depression has been in remission. Participants will be randomly assigned to either continue or discontinue AD treatment. Participants will be monitored for recurrence of depression and related symptoms for 1 year. Self reports and depression scales will be used to assess participants.
Eligibility:
Study Type:  Interventional, Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Safety/Efficacy Study
Minimum Age/Maximum Age: 65 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Current use of antidepressant medication - Have been in remission from first episode of depression for 6 months or longer - Of sound mind Exclusion Criteria: - Bedridden - Severe cognitive impairment
Total Enrollment: 240

Location and Contact Information:

University of Pennsylvania *Recruiting*
Philadelphia,  Pennsylvania,  19104
United States
Recruiting Ira  Katz


Additional Information:
Study ID Numbers:  MH51247-11A1; 
Study Start Date: November 2003
Record last reviewed: January 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00076622

Other Depression Studies:
1. Preventing the Return of Depression in Elderly Patients

2. Therapy for Depression with Co-occurring Panic or Anxiety Symptoms

3. Examination of a Soy-Based Supplement for Major Depression

4. Interactions of Depressed Mothers with Their Infants

5. Reducing Depression in Caregivers to People with Dementia

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