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Magnetic Stimulation of the Human Nervous System



Magnetic Stimulation of the Human Nervous System

For Condition: Demyelinating Disease,Healthy,Lysosomal Storage Disease,Motor Neuron Disease,Movement Disorder
Status: Recruiting
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) ,
Synopsis: Transcranial Magnetic Stimulation (TMS) is a non-invasive technique to gather information about brain function. It is very useful when studying the areas of the brain related to motor activity (motor cortex, corticospinal tract, spinal cord and nerve roots). The procedure is conducted by transmitting a magnetic signal into the brain to stimulate an area of the body. Electrodes (small pieces of metal taped to areas of the body) are used in order to measure electrical activity. A magnetic signal is sent from a metal instrument held close to the patient's head, to an area of the brain responsible for motor activity of a certain area of the body. The electrodes pick up and record the electrical activity in the muscles. This study will employ the use of TMS to diagnose neurological disorders that affect the motor cortex or the corticospinal tract. Normal subjects are sometimes studied to investigate normal activity of the nervous system and to train doctors in clinical neurophysiology and electrodiagnostic medicine at the National Institutes of Health (NIH).
Details: This protocol outlines the use of magnetic stimulation as a diagnostic tool in patients with suspected dysfunction of central motor pathways or nerve roots and as a tool to localize and characterize suspected corticospinal abnormalities in neurologic disorders and systemic disorders with neurological manifestations. The protocol is intended for clinical use. Transcranial magnetic stimulation has been used for diagnosis of neurologic disorders since 1987. The principles of magnetic stimulation and its use for diagnosis are described in current textbooks of clinical neurophysiology as a routine procedure and should be included in the training program for fellows in clinical neurophysiology and electrodiagnostic medicine at NIH. The magnetic stimuli are to be given as single or paired pulses at repetition rates less than 1 per second.
Eligibility:
Study Type:
  Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Adult patients with weakness or motor dysfunction. Children and adolescents with corticospinal tract signs. Normal volunteers, adults. Normal volunteers, children aged 4-17. EXCLUSION CRITERIA: Pregnant women. Subjects with implanted devices: pacemakers, medication pumps or defibrillators. Subjects with metal in the cranium except the mouth. Subjects with intracardiac lines. Normal subjects with history of seizures.
Total Enrollment: 450

Location and Contact Information:

National Institute of Neurological Disorders and Stroke (NINDS) *Recruiting*
Bethesda,  Maryland,  20892
United States
Recruiting Patient  and Public Liaison Office 1-800-411-1222


Additional Information:
Study ID Numbers:
  980065;  98-N-0065
Study Start Date: February 10, 1998
Record last reviewed: December 9, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001780

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