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Magnetic Stimulation for Parkinson Disease Clinical Trials Facts presented on Clinical Trials Search is not designed to be a substitute for certified medical advice, travels to or professional assistance by using a genuine doctor. We aren't mDs. Always consult your physician about Magnetic Stimulation for Parkinson Disease conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Magnetic Stimulation for Parkinson Disease Clinical research trials and Magnetic Stimulation for Parkinson Disease health trials occur in a lot of of cities throughout the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the potency of new does drugs. The role of the studies / undertakings is to figure out specific human healthcare questions. Clinical trials are a popular manner for mDs, government agencies, and private sector companies to locate treatments for all sorts of conditions, including Magnetic Stimulation for Parkinson Disease. Magnetic Stimulation for Parkinson Disease Clinical Trials and other clinical trials permit volunteers to get medical treatment choices before they are available to the general public. Many times the test subjects get professional assistance for free of charge, and occasionally they are compensated for their time. Sometimes there is a cost for a Magnetic Stimulation for Parkinson Disease clinical trial. Human subjects often get the best healthcare possible for their Magnetic Stimulation for Parkinson Disease condition. Risks are a reality, nevertheless, and could include additional or frequent dr. calls, medical hazards (perhaps life-threatening), and/or the treatment being ineffectual. Trials are federally governed with exacting guidelines to protect clinical trials patients.
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Home > "M" Clinical Trials Conditions > Magnetic Stimulation for Parkinson Disease  Magnetic Stimulation for Parkinson Disease
Magnetic Stimulation for Parkinson Disease
For Condition: Parkinson's Disease,Depression
Status: Recruiting
Sponsor(s): National Center for Complementary and Alternative Medicine (NCCAM) ,
Synopsis: During transcranial magnetic stimulation (TMS), a magnetic coil is placed on the front part of the head. Electric current passes through the coil in brief pulses. Magnetism from the current produces a separate, small electric current inside the brain, which activates brain cells below the coil. This treatment may result in decreased depression and improved Parkinson's disease symptoms.
Details: The major aim of this study is to carry out a sequential Phase I trial of prefrontal transcranial magnetic brain stimulation (TMS) and electroconvulsive therapy (ECT) in patients with Parkinson's disease (PD) and severe depression. Depression complicates PD in up to 50% of cases, leading to further deterioration of motor performance and quality of life; but antidepressant medication fails or produces intolerable side effects in 25-30% of patients. Case reports and uncontrolled trials suggest that ECT is effective in ameliorating simultaneously the mood and motor symptoms of PD. Only a few small studies of ECT in PD have been prospective or randomized, the assessment protocols have been limited, and the results have been variable. TMS is a new, promising, alternative treatment for refractory depression, which appears to be easier and safer than ECT. Requiring no hospitalization, anesthesia, or recovery time, TMS is now being investigated as an alternative therapy for mood disorders. TMS has not been studied in depressed patients with PD or in other serious central nervous system diseases. This study extends our past and present research in PD, depression, ECT, and TMS. We will comprehensively evaluate the effects of left prefrontal TMS on mood, motor, and neuropsychological function, together with quality of life indices in depressed PD patients. All patients will initially receive treatment with TMS. Those who fail to benefit will proceed to ECT. Comprehensive evaluation will be continued for another eight weeks in both the TMS-only and ECT groups. The key issues addressed by these studies include: (1) the potential benefit of TMS on mood and movement in depressed PD patients, and (2) the tightness of the association between mood and motor function after TMS and ECT. Overall, these studies will provide important preliminary data on the relationships among mood, cognitive and motor function in PD, and their influence on quality of life. The results will help in directing future applications of TMS as an alternative therapy for brain disorders, and will further elucidate the relative benefits of both TMS and ECT in depressed PD patients. A positive effect from TMS should be an impetus towards randomized, placebo-controlled trials.
Eligibility:
Study Type: Interventional, Treatment, Non-Randomized, Open Label, Dose Comparison, Single Group Assignment, Bio-equivalence Study
Minimum Age/Maximum Age: 40 Years/75 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Have a diagnosis of idiopathic Parkinson's Disease and meet DSM-IV criteria for Major Depressive Episode, severe, with or without psychotic features, or for Mood Disorder secondary to PD with major depression-like episode. - Have demonstrated an inadequate clinical response to at least one antidepressant medication in adequate dosage for at least six weeks, or an adverse event requiring discontinuation.
Total Enrollment: 50
Location and Contact Information:
Emory University *Recruiting*
Atlanta, Georgia, 30322
United States
Recruiting Charles Epstein
Additional Information:
Study ID Numbers: 1 R01 AT00610-01;
Study Start Date: August 2000
Record last reviewed: October 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00029276
Other Depression Studies:
1. Riluzole to Treat Parkinson's Disease
2. Farming and Movement Evaluation Study (FAME)
3. Magnetic Stimulation for Parkinson Disease
4. KW-6002 to Treat Parkinson's Disease
5. Deep Brain Stimulation (DBS) vs. Best Medical Therapy (BMT) Trial
Related Studies:
Other Depression Clinical Trials
Other Georgia Clinical Trials
Other Atlanta Clinical Trials
Magnetic Stimulation for Parkinson Disease
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