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Magnetic Resonance Imaging in Children and Adults Using Arterial Spin Tagging Techniques Clinical Trials Info presented on Clinical Trials Search is not intended to be a substitute for certified medical advice, visits or professional assistance using a real physician. We are not physicians. Always consult your dr. about Magnetic Resonance Imaging in Children and Adults Using Arterial Spin Tagging Techniques conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Magnetic Resonance Imaging in Children and Adults Using Arterial Spin Tagging Techniques Clinical research trials and Magnetic Resonance Imaging in Children and Adults Using Arterial Spin Tagging Techniques health trials happen in many of localities throughout the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically measure the effectualness of new drugs. The function of the studies / projects is to resolve particular human medical questions. Clinical trials are a popular manner for mDs, government agencies, and private sector corporations to discover remedies for all varieties of circumstances, like Magnetic Resonance Imaging in Children and Adults Using Arterial Spin Tagging Techniques. Magnetic Resonance Imaging in Children and Adults Using Arterial Spin Tagging Techniques Clinical Trials and other clinical trials allow volunteers to obtain healthcare treatment options before they are available to the masses. Some times the participants undergo professional assistance for free of charge, and occasionally they are paid for their time. Sometimes there is a cost for a Magnetic Resonance Imaging in Children and Adults Using Arterial Spin Tagging Techniques clinical trial. Human subjects often get the best healthcare available for their Magnetic Resonance Imaging in Children and Adults Using Arterial Spin Tagging Techniques condition. Dangers are a reality, however, and may include additional or frequent mD visits, healthcare dangers (potentially life-jeopardising), and/or the treatment being ineffectual. Trials are federally governed with rigorous guidelines to protect clinical trials patients.
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Home > "M" Clinical Trials Conditions > Magnetic Resonance Imaging in Children and Adults Using Arterial Spin Tagging Techniques  Magnetic Resonance Imaging in Children and Adults Using Arterial Spin Tagging Techniques
Magnetic Resonance Imaging in Children and Adults Using Arterial Spin Tagging Techniques
For Condition: Healthy
Status: Recruiting
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) ,
Synopsis: This study will use magnetic resonance imaging (MRI) to examine how blood flow to the brain differs at different ages with the brain is at rest, and during performance of tasks that involve language, memory, motor control, and sight. The study will evaluate the usefulness of MRI in identifying language function and location, and may provide information on how the brain develops over time to process brain functions, such as language and memory. Healthy normal volunteers in three age groups-children 8-10, adolescents 13-16, and young adults 21-30-may be eligible for this study. Participants must be right-handed and be native English speakers. Candidates will be screened via a telephone interview and examination by a neurologist. Participants will undergo MRI scanning of the brain during rest or while performing a task designed to test a skill. The tasks may involve remembering numbers, reading a word, tapping fingers, or looking at a flashing picture. MRI uses a magnetic field and radio waves to produce pictures of the brain. For the procedure, the subject lies still on a table that is moved into the scanner (a cylinder containing the magnet). Earplugs are worn to muffle loud noises caused by electrical switching of radio frequency circuits used in the scanning process. Adults may spend as long as 90 minutes in the scanner, usually less than 45 minutes. For children, the time is less than 75 minutes-usually 30 to 40 minutes. Participants may be asked to repeat the scans up to 5 times in different sessions to test different brain functions or confirm findings.
Details: FMRI using BOLD technique is an indirect and relative measure of neuronal activity and makes comparison among age groups problematic in light of known age related changes in glucose consumption and resting cerebral blood flow. In this study Arterial Spin Tagging techniques will be used to perform quantitative measures of blood flow changes during fMRI tasks. Children and adults will perform four tasks: primary sensory (photic flash), primary motor (finger tapping), and cognitive (working memory and semantic decision) tasks using parametric block designs, to account for developmental performance, using imaging parameters that allow quantitative measures of cerebral blood flow response as well as BOLD signal. Three age groups will be studied, children 8-10, 14-16, and young adults (21-28). Data will be analyzed using AFNI to identify activated areas. Further analysis will be performed using a region of interest analysis. We will compare quantitative measures at optimal performance levels. The three experimental age groups will be compared for delta rCBF and extent of activated area for each task. The study will determine age dependent changes in blood flow response during cortical activation across ages.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Right-handed (Edinburgh Handedness Inventory) Native English speaker (for language and memory paradigms only) EXCLUSION CRITERIA: Medical or technical contraindications to MRI procedures (e.g. no braces, pacemakers, cochlear devices, surgical clips, etc..) History of neurologic or psychiatric disease or a learning or attentional disorder One year below grade level CNS active medications Pregnancy Claustrophobia Inability to comply with the protocol Volunteers will also be asked if they have a history of dry or irritated eyes and informed this may increase the risk of eye irritation and discomfort in the 3T scanner.
Total Enrollment: 70
Location and Contact Information:
National Institute of Neurological Disorders and Stroke (NINDS) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 020182; 02-N-0182
Study Start Date: April 18, 2002
Record last reviewed: April 25, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00034073
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Magnetic Resonance Imaging in Children and Adults Using Arterial Spin Tagging Techniques
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