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Magnetic Resonance Angiography (MRA) for the Diagnosis of Atherosclerosis Clinical Trials Data presented on Clinical Trials Search isn't meant to be a substitute for qualified health advice, calls or treatment using a genuine doctor. We are not docs. Always consult your dr. on Magnetic Resonance Angiography (MRA) for the Diagnosis of Atherosclerosis conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Magnetic Resonance Angiography (MRA) for the Diagnosis of Atherosclerosis Clinical research trials and Magnetic Resonance Angiography (MRA) for the Diagnosis of Atherosclerosis healthcare trials occur in a lot of of places throughout the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the potency of new drugs. The intent of the studies / undertakings is to figure out certain human medical questions. Clinical trials are a popular means for mDs, government agencies, and private sector corporations to locate remedies for all kinds of circumstances, including Magnetic Resonance Angiography (MRA) for the Diagnosis of Atherosclerosis. Magnetic Resonance Angiography (MRA) for the Diagnosis of Atherosclerosis Clinical Trials and other clinical trials allow volunteers to obtain health treatment alternatives before they are available to the masses. Many times the participants undergo treatment for free, and sometimes they are paid for their time. Occasionally there is a cost for a Magnetic Resonance Angiography (MRA) for the Diagnosis of Atherosclerosis clinical trial. Participants typically obtain the most effective healthcare available for their Magnetic Resonance Angiography (MRA) for the Diagnosis of Atherosclerosis condition. Dangers are a reality, nonetheless, and can include extra or frequent mD trips, medical hazards (potentially life-endangering), and/or the treatment being uneffective. Trials are federally regulated with rigid guidelines to protect clinical trials patients.
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Home > "M" Clinical Trials Conditions > Magnetic Resonance Angiography (MRA) for the Diagnosis of Atherosclerosis  Magnetic Resonance Angiography (MRA) for the Diagnosis of Atherosclerosis
Magnetic Resonance Angiography (MRA) for the Diagnosis of Atherosclerosis
For Condition: Atherosclerosis
Status: Recruiting
Sponsor(s): Warren G Magnuson Clinical Center (CC) ,
Synopsis: Magnetic Resonance Angiography (MRA) is a method used to evaluate arteries and veins without the use of invasive catheters or x-rays (radiation). MRA technique has been continuously improving and has become more accurate at diagnosing problems of narrowing in blood vessels. However, MRA has a difficult time detecting narrowing in small blood vessels, limiting its use to large arteries. The purpose of this study is to recruit patients diagnosed with or suspected of having, atherosclerosis (hardening of the arteries) to participate in a series of new state-of-the-art diagnostic tests using MRA. This study is a combined effort between the National Institutes of Health (NIH), Uniformed Services University of the Health Sciences (USUHS), and General Electric Medical Services and is supported a Cooperative Research Agreement is to (CRADA). The goal of this study is to improve MRA to the point that it can reliably replace diagnostic x-ray catheter angiography in the evaluation of patients with atherosclerosis.
Details: Contrast Enhanced Magnetic Resonance Angiography (MRA) is a developing technology that permits the non-invasive evaluation of arterial and venous structures without the need for x-ray based catheter angiography. While dramatic progress has been made in the last few years, there are still substantial limitations in the accuracy of MRA in judging stenoses and detecting small accessory vessels. The purpose of this study is to recruit patients with suspected or documented atherosclerotic disease for evaluation with state-of-the-art MRA using new surface coils, new pulse sequence designs, novel contrast administration strategies, and advanced image processing algorithms. This work represents a collaboration between NIH, USUHS and General Electric Medical Systems and is supported by a Cooperative Research Agreement (CRADA). The goal of this pilot study is to improve MRA to the point that it can reliably replace diagnostic x-ray catheter angiography in the evaluation of patients with atherosclerotic disease.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Patients must live in the Metropolitan Washington Area. Patients must have suspected atherosclerotic disease based on clinical findings or documented by angiography or doppler ultrasound performed within 3 months of the MRA. Patients must be willing to participate in the protocol. Patients must be referred by a physician who is caring for the patient and to whom the results will be provided. Patients must be clinically stable and be judged by their physician able to come to the Clinical Center to participate in the study. Patients must have serum Creatinine value less than 3.0 mg/dl. EXCLUSION CRITERIA: Any contraindication for MRI including: (a) pacemaker or other implanted electronic device; (b) cochlear implants; (c) metal in the eye; (d) embedded shrapnel fragments; (e) cerebral aneurysm clips; or (f) medical infusion pumps. Allergy to Gadolinium based contrast media. Unsatisfactory performance status as judged by the referring physician such that the patient could not tolerate an MRI scan. Examples of medical conditions that would not be accepted would include angina, dyspnea at rest, congestive heart failure, severe claudication (less than 1 flight of steps). Intercurrent illness that requires treatment that would be jeopardized by the MRA scan. Subjects requiring sedation for MRI studies. Pregnant female. Patients with severe back-pain who will be unable to tolerate supine positioning within the MRI scanner for the duration of the examination.
Total Enrollment: 100
Location and Contact Information:
Warren G. Magnuson Clinical Center (CC) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 990061; 99-CC-0061
Study Start Date: March 10, 1999
Record last reviewed: February 25, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001841
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Magnetic Resonance Angiography (MRA) for the Diagnosis of Atherosclerosis
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