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Longitudinal and Biological Study of Childhood Disintegrative Disorder



Longitudinal and Biological Study of Childhood Disintegrative Disorder

For Condition: Autism,Pervasive Child Development Disorders
Status: Terminated
Sponsor(s): National Institute of Child Health and Human Development (NICHD) , Yale University
Synopsis: OBJECTIVES: I. Compare the developmental course (language acquisition, diagnostic stability, predictors of outcome, and restricted interests and behaviors) of childhood disintegrative disorder versus autism and non-autistic developmental delays. II. Collect data on molecular genetics of proband and family members.
Details: PROTOCOL OUTLINE: Patients are evaluated with the following questionnaires at ages 2-3 years and again at ages 5-9: The Autism Diagnostic Interview (ADI); The Autism Diagnostic Observation Schedule (ADOS); Assessment of cognitive functioning; Expressive and receptive language; Adaptive functioning; Measures of burden and functional assessment; The Aberrant Behavior Checklist; The Connors Rating Scale - Parent and Teacher version; and Autism Behavior Checklist An MRI and EEG are performed, and blood samples are collected from patients and family members for molecular genetic studies.
Eligibility:
Study Type:
  Observational, Screening, Longitudinal
Minimum Age/Maximum Age: 2 Years/9 Years
Genders: Both
Protocol Entry Criteria: - Psychologically diagnosed (DSM-IV) as Childhood Disintegrative Disorder - No known genetic or medical syndrome (Down syndrome or cerebral palsy) - Must speak English
Total Enrollment: 220

Location and Contact Information:

Overall Study Official:
FredVolkmar,  Study Chair,  Yale University

University of Chicago Cancer Research Center
Chicago,  Illinois,  60637
United States
 

Yale Child Study Center
New Haven,  Connecticut,  06520
United States
 


Additional Information:
Study ID Numbers:
  199/13682;  YALE-5P01HD0300830,YALE-HIC-5895
Study Start Date: May 1997
Record last reviewed: October 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004458

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