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Home > "L" Clinical Trials Conditions > Lipoprotein Metabolism in Hypertensive African-Americans  Lipoprotein Metabolism in Hypertensive African-Americans
Lipoprotein Metabolism in Hypertensive African-Americans
For Condition: Hypertension,Cardiovascular Diseases,Hyperinsulinism,Heart Diseases,Insulin Resistance
Status: Completed
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: To study relationships among lipoprotein metabolism, hypertension, and hyperinsulinemia-insulin resistance in African American males and females. The study was part of a Collaborative Project on Minority Health which investigated the mechanisms by which insulin contributes to cardiovascular disease.
Details: BACKGROUND: The study was part of the initiative "Collaborative Projects (R01s) on Minority Health". The concept for the initiative was developed by the NHLBI staff after the 1993 Report of the Committee on Appropriations, House of Representatives, encouraged the NHLBI to establish minority centers to facilitate the diagnosis and treatment of cardiovascular diseases. The initiative was approved at the September 1992 National Heart, Lung, and Blood Advisory Council and released in October 1992. Julian Marsh was one of three investigators in a collaborative program with Bonita Falkner as Program Coordinator. DESIGN NARRATIVE: In a sub-set of subjects with either high or low plasma insulin levels after a glucose challenge (insulin sensitive or insulin resistant), the investigators determined the fractional and absolute synthesis and catabolic rates of apolipoproteins B and A-I, the dominant lipoproteins of Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL). They used stable isotopes and multicompartmental kinetic analysis following an oral bolus dose of deuteroleucine. They hypothesized that in hypertensive African Americans with hyperinsulinemia, more of the smaller Very Low Density (VLDL) particles are secreted and converted to LDL.
Eligibility:
Study Type: Observational, Natural History, Longitudinal
Minimum Age/Maximum Age: /
Genders: Male
Protocol Entry Criteria: No eligibility criteria
Total Enrollment:
Location and Contact Information:
Additional Information:
Study ID Numbers: 4918;
Study Start Date: September 1993
Record last reviewed: June 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00005709
Other Cardiovascular Diseases Studies:
1. Genomewide Search for Loci Underlying Metabolic Syndrome
2. A clinical trial to prevent the complications of insulin resistance (including type-2 diabetes)
3. Study of Recombinant Human Insulin-Like Growth Factor I in Patients with Severe Insulin Resistance
4. Central Obesity and Disease Risk in Japanese Americans
5. Lipoprotein Metabolism in Hypertensive African-Americans
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Lipoprotein Metabolism in Hypertensive African-Americans
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