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Home > "L" Clinical Trials Conditions > Lipid Variability--Influence of Stress  Lipid Variability--Influence of Stress
Lipid Variability--Influence of Stress
For Condition: Heart Diseases,Cardiovascular Diseases,Hypercholesterolemia
Status: Completed
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: To investigate the variability of lipids and specifically the effects of stress on serum triglyceride levels, total cholesterol, HDL, and LDL in a 2.5 year epidemiological study.
Details: BACKGROUND: While researchers had documented some of the behavioral contributors to fluctuation in individuals' lipid levels (e.g., nutrition patterns, smoking, exercise), little attention had been given to psychosocial stress. Early reports utilizing accountants, race car drivers, and air traffic controllers provided some uncontrolled data associating stress with cholesterol increases. Yet, no empirical research on stress that concomitantly examined other related influences was available. This paucity of data was probably due to lack of objective measures of stress and difficulty in measuring lipid subfractions. DESIGN NARRATIVE: Based on the results of their pilot study, and their research observations, the investigators predicted significant positive associations between stress level and triglycerides. A total of 228 public accountants (148 men and 80 women to provide comparable power between the sexes) were recruited from the greater Birmingham, Alabama area. Participants were evaluated monthly for 18 months, across three stressful and non-stressful work intervals (i.e., tax seasons). The investigators also collected data (during this same time frame) to closely monitor the following variables that affect lipids: dietary intake (including alcohol, caffeine, total calories, total fat, saturated fat, and dietary cholesterol), smoking, and physical activity, and oral contraceptive use, pregnancy status and menstrual stage among the women. Additionally, a substudy presented a unique opportunity for them to investigate the relation between stress and triglyceride-rich lipoproteins in the formation of foam cells.
Eligibility:
Study Type: Observational, Natural History, Longitudinal
Minimum Age/Maximum Age: /
Genders: Male
Protocol Entry Criteria: No eligibility criteria
Total Enrollment:
Location and Contact Information:
Additional Information:
Study ID Numbers: 4913;
Study Start Date: July 1990
Record last reviewed: June 2000
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00005468
Other Hypercholesterolemia Studies:
1. Serum Total Homocysteine and C-Reactive Protein - Ancillary to IDNT
2. Chronic Stress as a Risk Factor in the Etiology of Coronary Heart Disease
3. Exercise and Blood Pressure in Children: A Meta-Analysis
4. Polyunsaturated Fats and Risk of Primary Cardiac Arrest
5. Polyunsaturates and KCL to Control Mild Hypertension
Related Studies:
Other Hypercholesterolemia Clinical Trials
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Lipid Variability--Influence of Stress
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