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Lead Mobilization & Bone Turnover in Pregnancy/Lactation



Lead Mobilization & Bone Turnover in Pregnancy/Lactation

For Condition: Lead Poisoning
Status: No longer recruiting
Sponsor(s): National Institute of Environmental Health Sciences (NIEHS) ,
Synopsis: We are examining the role of maternal bone lead turnover during pregnancy and lactation as a potential source of lead exposure for the fetus and the infant (via breast milk). A cohort, ascertained at entry to care, consists of >1000 women to be followed through pregnancy. In the postpartum subjects are recruited for a nested case control study to assess the influence of lactation on maternal bone density, maternal blood lead and breast milk lead.
Details:
Eligibility:
Study Type:
  Observational, Natural History, Longitudinal, Convenience Sample, Prospective Study
Minimum Age/Maximum Age: 12 Years/35 Years
Genders: Female
Protocol Entry Criteria: 1.Positive pregnancy test, age 12-35 and informed consent; 2.Gestation <28 weeks at entry to prenatal care; 3.No history of serious chronic or metabolic diseases, which could affect maternal growth or bone density; 4.Not corticosteroid user or diagnosed use of illicit drugs; 5.Eligible for lactation study: Ascertainment during or participation in the pregnancy study and a negative pregnancy test.
Total Enrollment: 1000

Location and Contact Information:


Additional Information:
Study ID Numbers:
  7437-CP-001; 
Study Start Date: August 1996
Record last reviewed: July 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00011726

Other Lead Poisoning Studies:
1. Bone Lead Levels and College Achievement Scores

2. Does Lead Burden alter Neuropsychological Development?

3. Environmental Contaminants and Infant Development

4. Randomized Study of Succimer (Dimercaptosuccinic Acid) on Growth of Lead-Poisoned Children

5. Lead, Endocrine Disruption and Reproductive Outcomes

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