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Lactobacillus plantarum as therapy for NK-T cell deficiency



Lactobacillus plantarum as therapy for NK-T cell deficiency

For Condition: Diabetes Mellitus
Status: Completed
Sponsor(s): National Center for Research Resources (NCRR) ,
Synopsis: The etiology of immune-mediated diabetes mellitus (IMD) remains unclear. However, previous studies indicate that autoimmunity may be a result of dysfunction of natural killer T cells (NK-T cells). Newly diagnoses patients with IMD have been shown in our laboratory to have significantly lower NK-T cells than normal controls. Other studies have shown that oral administration of lactobacillus can boost NK-T cell activity in children with HIV without side effects. Our objective is to evaluate the effect of lactobacillus administration on NK-T cell activity in patients with IMD
Details:
Eligibility:
Study Type:
  Interventional, Treatment, Randomized, Double-Blind, Placebo Control, Single Group Assignment, Efficacy Study
Minimum Age/Maximum Age: 1 Year/95 Years
Genders: Both
Protocol Entry Criteria: Recently diagnosed (within the last 6 months) patients with immune-mediated (type 1) diabetes
Total Enrollment: 

Location and Contact Information:

Cornell University
New York City,  New York,  10021
United States
 


Additional Information:
Study ID Numbers:
  NCRR-M01RR06020-0165; 
Study Start Date: 
Record last reviewed: December 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00011141

Other Diabetes Mellitus Studies:
1. Serum Total Homocysteine and C-Reactive Protein - Ancillary to IDNT

2. Multi-Ethnic Study of Atherosclerosis (MESA)

3. Cohort Study of Heart Rate Variability

4. Assessing Continuous Glucose Monitors in Healthy Children

5. Laser and Medical Treatment of Diabetic Macular Edema

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Lactobacillus plantarum as therapy for NK-T cell deficiency

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