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Invaplex 50 Vaccine Dose-Ranging



Invaplex 50 Vaccine Dose-Ranging

For Condition: Diarrhea
Status: Recruiting
Sponsor(s): Walter Reed Army Institute of Research (WRAIR) ,
Synopsis: The vaccine is given as a nose spray. Volunteers will receive a 3-dose vaccination with doses spaced two weeks apart. Volunteers will be assigned to a vaccination group based on their order of enrollment with consideration of their availability to complete the necessary vaccinations and follow-up visits.
Details:
Eligibility:
Study Type:  Interventional, Prevention, Non-Randomized, Open Label, Dose Comparison, Single Group Assignment, Safety/Efficacy Study
Minimum Age/Maximum Age: 18 Years/40 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Be in very good health. Exclusion Criteria: - Smoker, or have stopped smoking less than one year ago - Pregnant - History of chronic illnesses, such as: asthma, chronic sinusitis, or chronic seasonal allergies (such as hay fever) - Received a vaccination for Shigella or exposure to Shigella bacteria in a research study or through work in a laboratory - Positive for HIV, hepatitis B, and hepatitis C by blood test - Using anti-diarrheal, anti-constipation, or antacid medications on a regular basis
Total Enrollment: 32

Location and Contact Information:

Walter Reed Army Institute of Research *Recruiting*
Silver Spring,  Maryland,  20910
United States
Recruiting Oman  Salazar 866-856-3259


Additional Information:
Study ID Numbers:  Invaplex50;  1085
Study Start Date: April 2004
Record last reviewed: April 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00082069

Other Diarrhea Studies:
1. A Multicenter Placebo-Controlled Double Blind Study to Evaluate the Efficacy and Safety of Sandostatin ( SMS 201-995 ) in Patients with Acquired Immunodeficiency Related Diarrhea who were Either "Responders" or "Non-Responders" in a Prior Placebo-Controlled Double-Blind Sandostatin Study.

2. Treatment of Patients With Human Immunodeficiency Virus (HIV)-Related Chronic Diarrhea With Saccharomyces boulardii or Placebo: A Double Blind Trial

3. Genetic Trial to Study Diarrhea in Patients With Stage III Colon Cancer Who Are Receiving Chemotherapy

4. Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea

5. Pentosan Polysulfate in Treating Patients With Gastrointestinal Disturbance Caused by Radiation Therapy

Related Studies:

Other Diarrhea Clinical Trials
Other Maryland Clinical Trials
Other Silver Spring Clinical Trials

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