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Infusion Laboratory: Protocol 1 - Selegeline - 2



Infusion Laboratory: Protocol 1 - Selegeline - 2

For Condition: Cocaine-Related Disorders
Status: Completed
Sponsor(s): National Institute on Drug Abuse (NIDA) ,
Synopsis: Objectives: 1) To determine the effects of selegeline on the subjective and physiological effects of cocaine challenge in chronic crack abusers. 2) To evaluate clinical safety issues pertaining to selegeline, to cocaine and their interaction in a chronic crack dependent population.
Details: To develop a medication for the treatment of cocaine addiction using a medical human physio-neuro-psycho-immunology laboratory setting. To characterize this cocaine abusing population on a variety of psychological and physicologically measures over time from withdrawal through pere and post cocaine administration. To determine the effects of selegeline on the subjective and physiological effects of cocaine challenge in chronic crack abusers. To evaluate clinical safety issues pertaining to selegeline, to cocaine and their interaction in a chronic crack dependent population.
Eligibility:
Study Type:
  Interventional, Treatment, Uncontrolled
Minimum Age/Maximum Age: 31 Years/47 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: M/F, ages 21-50. Meet DSM-IV criteria for cocaine dependence. Agree to conditions of the study and sign informed consent. Exclusion Criteria: Psychiatric disorder that requires medication therapy. History of seizures. Pregnant and/or nuring women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics. Acute hepatitis. Other medical condtions that deem participation to be unsafe.
Total Enrollment: 0

Location and Contact Information:

Overall Study Official:
WalterLing,  Principal Investigator,  Friends Research Institute

Friends Research Institute
Los Angeles,  California,  90025
United States
 


Additional Information:
Study ID Numbers:
  NIDA-3-0010-2; 
Study Start Date: November 1994
Record last reviewed: August 1996
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00000337

Other Cocaine-Related Disorders Studies:
1. IV Cocaine Abuse: A Laboratory Model - 2

2. Effects of Phenytoin on Cocaine Use in Humans - 2

3. Infusion Laboratory: Protocol 2 (Lisuride) - 3

4. Serotonin/Dopamine Antagonism of Cocaine Effect - 2

5. Ritanserin in Treatment of Cocaine Dependence - 1

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Infusion Laboratory: Protocol 1 - Selegeline - 2

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