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Home > "I" Clinical Trials Conditions > Improving Substance Abuse Treatment Aftercare Adherence and Outcome  Improving Substance Abuse Treatment Aftercare Adherence and Outcome
Improving Substance Abuse Treatment Aftercare Adherence and Outcome
For Condition: Alcoholism,Substance Abuse
Status: Recruiting
Sponsor(s): Department of Veterans Affairs ,
Synopsis: We have 3 goals: 1) to compare the effectiveness of an aftercare intervention consisting of a participation contract, attendance prompts with feedback, and attendance reinforcers (CPR) to a standard treatment (STX) on adherence to aftercare therapy; 2) to assess the effects of this intervention on treatment outcome; and 3) to understand the process by which this intervention works.
Details: Although substance abuse treatment aftercare participation is strongly related to positive treatment outcomes, aftercare participation rates are low and relatively few interventions have been developed that improve aftercare adherence and outcome. We have shown in preliminary studies that contracting, prompting with feedback, and providing social reinforcement independently increase aftercare participation and improve treatment outcome. We propose a randomized clinical trial to examine a behaviorally based substance abuse treatment adherence intervention. Over a 1.5-year period, we will recruit 160 veterans seeking residential or intensive outpatient treatment at the Salem VAMC’s Substance Abuse Residential Rehabilitation Treatment Program (SARRTP) who can participate in aftercare therapy. Our population is highly similar to those in SARRTP’s throughout the VAMC (95% male, 52% Caucasian, 48% minority, 44 years mean age, 47% alcohol dependent, 16% drug dependent, 37% both alcohol and drug dependent, and 36% dual diagnosis). In this randomized clinical trial, participants will be assigned to the STX or the CPR condition. Treatment adherence and outcome will be measured 3-, 6- and 12-months after participants enter treatment and will be compared to baseline levels using structured interviews, questionnaires, urine alcohol and drug screens, VAMC databases, medical records, and therapist ratings. The basic study design is a repeated measures nested cohort design, with an intervention group and a standard care group. The primary outcome, abstinence rate, will be analyzed using a logistic regression model in which the parameters of interest are estimated using Generalized Estimating Equations (GEE). We will analyze secondary outcomes using both marginal and linear mixed-effects models.
Eligibility:
Study Type: Interventional, Treatment, Randomized, Open Label, Active Control, Single Group Assignment, Efficacy Study
Minimum Age/Maximum Age: 21 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: All participants in a VAMC residential substance abuse treatment program who: - Live within a 60 minute drive of our facility or outreach clincs. - Have transportation to allow outpatient care. - Have a work schedule allowing outpatient care
Total Enrollment: 160
Location and Contact Information:
VA Medical Center *Recruiting*
Salem, Virginia, 24153
United States
Recruiting Steven Lash 540-982-2463
Additional Information:
Study ID Numbers: IIR 99-282;
Study Start Date: August 2001
Record last reviewed: May 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00057187
Other Substance Abuse Studies:
1. Behavioral Counseling for Alcohol Dependent Smokers (nicotine patch)
2. Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (naltrexone/nicotine patch)
3. Comparing Gabapentin and Lorazepam for Treating Alcohol Withdrawal
4. Drug Therapy for Alcohol Dependence in Alaska Natives (naltrexone/sertraline)
5. Naltrexone for Relapse Prevention
Related Studies:
Other Substance Abuse Clinical Trials
Other Virginia Clinical Trials
Other Salem Clinical Trials
Improving Substance Abuse Treatment Aftercare Adherence and Outcome
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