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Immune Response to Influenza Vaccine in HIV-Infected Individuals Clinical Trials References presented on Clinical Trials Search is not intended to be a substitute for proven healthcare advice, trips or professional assistance by using a real medical. We aren't mDs. Always confer with your physician about Immune Response to Influenza Vaccine in HIV-Infected Individuals conditions. Clinical Trials Search.org is a website devoted to listing clinical research studies in human subjects. Immune Response to Influenza Vaccine in HIV-Infected Individuals Clinical research trials and Immune Response to Influenza Vaccine in HIV-Infected Individuals medical trials take place in hundreds of localities across the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually evaluate the effectualness of new does drugs. The purpose of the studies / projects is to solve specific human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to discover treatments for all sorts of conditions, such as Immune Response to Influenza Vaccine in HIV-Infected Individuals. Immune Response to Influenza Vaccine in HIV-Infected Individuals Clinical Trials and other clinical trials permit volunteers to access healthcare treatment choices before they are available to the general public. Some times the subjects recieve professional assistance for without cost, and every now and again they are compensated for their time. Sometimes there is a cost for a Immune Response to Influenza Vaccine in HIV-Infected Individuals clinical trial. Subjects often receive the most expert healthcare possible for their Immune Response to Influenza Vaccine in HIV-Infected Individuals condition. Risks are a reality, nevertheless, and could include additional or frequent dr. calls, healthcare dangers (perhaps life-jeopardising), and/or the treatment being ineffective. Trials are federally governed with stern guidelines to protect clinical trials subjects.
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Home > "I" Clinical Trials Conditions > Immune Response to Influenza Vaccine in HIV-Infected Individuals  Immune Response to Influenza Vaccine in HIV-Infected Individuals
Immune Response to Influenza Vaccine in HIV-Infected Individuals
For Condition: HIV Infections
Status: Recruiting
Sponsor(s): National Institute of Allergy and Infectious Diseases (NIAID) ,
Synopsis: This study will evaluate how HIV infection, including CD4 cell count and viral load, affects the patient's ability to produce antibodies in response to vaccination with the influenza (flu) vaccine. Earlier studies have shown that people with HIV infection do not respond as well as healthy subjects to flu vaccine; that is, they don't make as many antibodies in response to the vaccine. Before the use of current anti-HIV medications, antibodies made to flu vaccination in HIV-positive individuals was related to their CD4 cell count. This trial will examine how CD4 counts and the amount of virus in the blood affect how much and what kind of antibodies the body makes to the flu vaccine. HIV-infected patients and healthy normal volunteers between 18 and 60 years of age may be eligible for this study. Healthy subjects will serve as controls to make sure the flu vaccine works (i.e., stimulates production of enough antibody to protect against the flu), and to compare the amount of antibodies made by HIV-positive and HIV-negative people. Candidates will be screened with a medical history and blood tests (see below). Women who are able to have children will have a pregnancy test. Pregnant women are excluded from the study. Participants will undergo the following procedures: 1) Blood drawing for the following tests: - Routine tests (complete blood count, kidney and liver functions, electrolyte levels). - CD4 cell count. - HLA typing (a genetic marker of the immune system) if it has not already been done at the NIH. This test may be used to try to identify factors associated with the rate of progression of HIV disease or related conditions. Determining HLA type is necessary to be able to perform certain research studies. Some HLA types have been associated with an increased risk of certain diseases like arthritis and other rheumatologic problems. - Viral load (HIV-infected patients only). - Influenza antibody levels. - B cell levels. 2) Flu vaccination 3) Follow-up visits on days, 7, 28, and 54 after vaccination for the following: - Review of any illnesses or fever. - Review of medications, if any changes were made. - Repeat blood tests.
Details: The purpose of this protocol is to evaluate the effect of HIV viral load and CD4 counts on the generation of influenza-specific antibodies and influenza-specific B cell responses in HIV-infected adults. HIV-infected subjects will be enrolled to receive the influenza vaccine appropriate to the on-going USA influenza season (Oct-March). Laboratory studies (including influenza titers, influenza-specific B cell frequencies, CD4 counts, and HIV viral loads) will be obtained at baseline (day of vaccination), day 7, 28, and 54 post-vaccination. HIV-negative healthy volunteers will serve as controls. Although there are some risks to influenza vaccine, the CDC Advisory Committee on Immunizations recommends influenza vaccination for HIV-infected patients. The primary study risks are those of phlebotomy and the inconvenience of multiple visits. Subjects will be compensated for participation in the study. Total enrollment of the study is a maximum of 165 subjects (132 HIV-infected individuals and 33 HIV-negative controls).
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: HIV Positive: 1. Age greater than or equal 18 but less than or equal to 60 years old and willing and able to give informed consent 2. Enrollment during the USA influenza season (October-March) 3. Self-reported history of HIV infection at enrollment (If NIH HIV testing does not confirm that the subject is HIV-positive, the subject will be discontinued from the study and not included in the analysis.) HIV Negative: 1. Age greater than or equal to 18 but less than or equal to 60 years old and willing and able to give informed consent 2. Enrollment during USA influenza season (October-March) 3. Self-reported healthy HIV-negative (If NIH HIV testing does not confirm that the subject is HIV-negative, the subject will be discontinued from the study and not included in the analysis.) EXCLUSION CRITERIA: HIV Positive: 1. Self-reported history of vaccination with the trivalent influenza preparation used for the current influenza season 2. Self-reported vaccination with any vaccine within the one month period prior to study enrollment 3. Acute febrile illness (may defer vaccine until resolved) 4. History of hypersensitivity to any influenza vaccine components including thimerosal or egg 5. History of Guillain-Barre syndrome 6. Intention to receive any other vaccine during the study period 7. Pregnancy 8.Self-reported treatment with immunomodulator/immunosuppressive drugs (interleukins, corticosteroids, or G(M)-CSF in the 4 weeks prior to enrollment 9. Self-reported history of IL-2 administration within the past 5 years 10. Use of theophylline preparations or warfarin because of the theoretical possibilities, of enhanced drug effects and toxicities post influenza vaccination 11. Active infection or other serious illness other than HIV that might affect the immune response to a vaccine 12. Current alcohol, substance abuse, or systemic/psychiatric illness that potentially could interfere with patient compliance and ability to make study visits HIV Negative: 1. Self-reported history of vaccination with the trivalent influenza preparation used for the current influenza season 2. Self-reported vaccination with any vaccine within the one month period prior to study enrollment 3. Acute febrile illness (may defer vaccine until resolved) 4. History of hypersensitivity to any influenza vaccine components including thimerosal or egg 5. History of Guillain-Barre syndrome 6. Intention to receive any other vaccine during the study period 7. Pregnancy 8. Self-reported treatment with immunomodulator/immunosuppressive drugs (interleukins, corticosteroids, or G(M)-CSF in the 4 weeks prior to enrollment 9. Use of theophylline preparations or warfarin because of the theoretical possibilities, of enhanced drug effects and toxicities post influenza vaccination 10. Any medical conditions, or medication use might affect the immune response to a vaccine 11. Current alcohol, substance abuse, or systemic/psychiatric illness that potentially could interfere with patient compliance and ability to make study visit
Total Enrollment: 165
Location and Contact Information:
National Institute of Allergy and Infectious Diseases (NIAID) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 030310; 03-I-0310
Study Start Date: September 25, 2003
Record last reviewed: September 16, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00069914
Other Hiv Infections Studies:
1. Study Of Investigational Regimen Combining FDA Approved HIV Drugs In HIV Subjects Experiencing Early Virologic Failure
2. A Study on the Safety and Effectiveness of L-756423 Plus Indinavir in HIV-Positive Patients Who Have Previously Taken Indinavir
3. A Study of Dideoxycytidine Plus Zidovudine in the Treatment of AIDS or Advanced AIDS Related Complex (ARC)
4. Genetic Markers for Focal Segmental Glomerulosclerosis
5. A Study to Evaluate the Effects of Azithromycin on MAC Disease Prevention in HIV-Positive Patients
Related Studies:
Other HIV Infections Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Immune Response to Influenza Vaccine in HIV-Infected Individuals
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