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Imatinib Mesylate in Treating Patients With Primary or Recurrent Malignant Gastrointestinal Stromal Tumor Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for qualified medical advice, visits or professional assistance by using a real mD. We are not docs. Always confer with your physician about Imatinib Mesylate in Treating Patients With Primary or Recurrent Malignant Gastrointestinal Stromal Tumor conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Imatinib Mesylate in Treating Patients With Primary or Recurrent Malignant Gastrointestinal Stromal Tumor Clinical research trials and Imatinib Mesylate in Treating Patients With Primary or Recurrent Malignant Gastrointestinal Stromal Tumor health trials occur in many of cities throughout the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the effectivity of new does drugs. The intent of the studies / undertakings is to resolve particular human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to detect remedies for all sorts of conditions, including Imatinib Mesylate in Treating Patients With Primary or Recurrent Malignant Gastrointestinal Stromal Tumor. Imatinib Mesylate in Treating Patients With Primary or Recurrent Malignant Gastrointestinal Stromal Tumor Clinical Trials and other clinical trials permit volunteers to obtain healthcare treatment alternatives before they are available to the masses. Most times the participants undergo professional assistance for without cost, and occasionally they are compensated for their time. Occasionally there is a cost for a Imatinib Mesylate in Treating Patients With Primary or Recurrent Malignant Gastrointestinal Stromal Tumor clinical trial. Test subjects typically receive the most expert healthcare available for their Imatinib Mesylate in Treating Patients With Primary or Recurrent Malignant Gastrointestinal Stromal Tumor condition. Dangers are a reality, however, and may include more or frequent mD visits, healthcare dangers (perhaps life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with rigid guidelines to protect clinical trials patients.

Home > "I" Clinical Trials Conditions > Imatinib Mesylate in Treating Patients With Primary or Recurrent Malignant Gastrointestinal Stromal Tumor

Imatinib Mesylate in Treating Patients With Primary or Recurrent Malignant Gastrointestinal Stromal Tumor



Imatinib Mesylate in Treating Patients With Primary or Recurrent Malignant Gastrointestinal Stromal Tumor

For Condition: gastrointestinal stromal tumor
Status: Recruiting
Sponsor(s): Radiation Therapy Oncology Group , National Cancer Institute (NCI),American College of Radiology Imaging Network,Eastern Cooperative Oncology Group
Synopsis: RATIONALE: Imatinib mesylate may stop the growth of cancer cells by blocking the enzymes necessary for their growth. Giving imatinib mesylate before and after surgery may be an effective treatment for malignantgastrointestinal stromal tumor. PURPOSE: Phase II trial to study the effectiveness of neoadjuvant and adjuvant imatinib mesylate in treating patients who are undergoing surgery for primary or recurrent malignant gastrointestinal stromal tumor.
Details: OBJECTIVES: - Determine the progression-free survival of patients with primary or recurrent potentially resectable malignant gastrointestinal stromal tumor treated with neoadjuvant and adjuvant imatinib mesylate. - Determine the objective response rate of patients treated with this drug. - Determine the safety of this drug in these patients. OUTLINE: Patients receive oral imatinib mesylate once daily. Treatment continues for 8 weeks in the absence of disease progression. Patients with disease progression are considered for immediate surgical resection. Otherwise, after 8 weeks, patients undergo surgical resection to debulk all gross tumor. Two to four weeks after surgery, patients receive oral imatinib mesylate once daily for 2 years. Patients are followed every 3 months for 2 years and then every 6 months for 3 years. PROJECTED ACCRUAL: A total of 63 patients will be accrued for this study within 2 years.
Eligibility:
Study Type:
  Interventional, Treatment
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically confirmed malignant gastrointestinal stromal tumor - Potentially resectable primary disease OR - Potentially resectable recurrent disease - Local or intra-abdominal/pelvic metastatic disease - Documented c-kit (CD117) expression by immunohistochemical analysis of either initial core specimen or, if recurrent disease, from original tumor block - Primary disease must be visceral, intra-abdominal, or pelvic in origin - At least 1 unidimensionally measurable lesion - At least 5 cm for primary disease - At least 2 cm for recurrent disease - Required to have 3 core tissue biopsies performed at least 8 weeks before registration PATIENT CHARACTERISTICS: Age: - 18 and over Performance status: - Zubrod 0-2 Life expectancy: - Not specified Hematopoietic: - WBC at least 3,000/mm^3 - Absolute neutrophil count at least 1,500/mm^3 - Platelet count at least 100,000/mm^3 Hepatic: - Bilirubin no greater than 1.5 times upper limit of normal (ULN) - ALT/AST no greater than 2.5 times ULN - No uncontrolled chronic liver disease Renal: - Creatinine no greater than 1.5 times ULN - No uncontrolled chronic renal disease Cardiovascular: - No New York Heart Association class III or IV cardiac disease Other: - Must be able to lie still in the PET scanner for approximately 1-2 hours - No uncontrollable hyperglycemia - No medical or psychological condition that would preclude study participation - No severe or uncontrolled medical disease - No active uncontrolled infection - Any prior malignancy is allowed provided patient remains disease free from that malignancy - Not pregnant or nursing - Negative pregnancy test - Fertile patients must use effective barrier contraception during and for 3 months after study participation PRIOR CONCURRENT THERAPY: Biologic therapy: - At least 28 days since prior biologic therapy - No concurrent filgrastim (G-CSF) or sargramostim (GM-CSF) Chemotherapy: - At least 28 days since prior chemotherapy Endocrine therapy: - Not specified Radiotherapy: - At least 28 days since prior radiotherapy Surgery: - See Disease Characteristics Other: - At least 28 days since prior investigational drugs - At least 28 days since prior imatinib mesylate - No concurrent therapeutic doses of warfarin - Concurrent low-molecular weight heparin or mini-dose warfarin (1 mg per day) prophylaxis is allowed
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
AnnickVan den Abbeele,  Study Chair,  Dana-Farber/Harvard Cancer Center

Veterans Affairs Medical Center - Gainesville *Recruiting*
Gainesville,  Florida,  32608-1197
United States
Recruiting Dean  McCarley 352-374-6016

CCOP - Mayo Clinic Scottsdale Oncology Program *Recruiting*
Scottsdale,  Arizona,  85259-5404
United States
Recruiting Tom  Fitch 480-301-9875

CCOP - Missouri Valley Cancer Consortium *Recruiting*
Omaha,  Nebraska,  68106
United States
Recruiting James  Mailliard 402-280-4364

Veterans Affairs Medical Center - Madison *Recruiting*
Madison,  Wisconsin,  53705
United States
Recruiting Mark  Albertini 608-262-7017

Northwest Community Hospital *Recruiting*
Arlington Heights,  Illinois,  60005
United States
Recruiting Arnold  Herskovic 847-618-6576

Iowa Lutheran Hospital *Recruiting*
Des Moines,  Iowa,  50316-2301
United States
Recruiting Roscoe  Morton 515-663-5612

MBCCOP-Our Lady of Mercy Cancer Center *Recruiting*
Bronx,  New York,  10466
United States
Recruiting Peter  Wiernik 718-920-1100

Beth Israel Deaconess Medical Center *Recruiting*
Boston,  Massachusetts,  02215
United States
Recruiting Michael  Atkins 617-667-1930

LDS Hospital *Recruiting*
Salt Lake City,  Utah,  84143
United States
Recruiting William  Sause 801-408-1146

Veterans Affairs Medical Center - East Orange *Recruiting*
East Orange,  New Jersey,  07019
United States
Recruiting Basil  Kasimis 973-676-1000 ext. 1544

Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center *Recruiting*
Nashville,  Tennessee,  37232-6307
United States
Recruiting David  Johnson 615-343-9454

Roswell Park Cancer Institute *Recruiting*
Buffalo,  New York,  14263-0001
United States
Recruiting Michael  Kuettel 716-845-1562

CCOP - Sioux Community Cancer Consortium *Recruiting*
Sioux Falls,  South Dakota,  57104
United States
Recruiting Loren  Tschetter 605-328-8044

Fox Chase Cancer Center *Recruiting*
Philadelphia,  Pennsylvania,  19111
United States
Recruiting Benjamin  Movsas 215-728-3631

CCOP - Kalamazoo *Recruiting*
Kalamazoo,  Michigan,  49007-3731
United States
Recruiting Raymond  Lord 269-373-7488

Medical College of Wisconsin Cancer Center *Recruiting*
Milwaukee,  Wisconsin,  53226-3596
United States
Recruiting David  Vesole 414-805-4646

H. Lee Moffitt Cancer Center and Research Institute *Recruiting*
Tampa,  Florida,  33612-9497
United States
Recruiting Julie  Kish 813-972-8432

Veterans Affairs Medical Center - Wichita *Recruiting*
Wichita,  Kansas,  67218
United States
Recruiting Shaker  Dakhil 316-685-2221

Barbara Ann Karmanos Cancer Institute *Recruiting*
Detroit,  Michigan,  48201-1379
United States
Recruiting Anthony  Shields 313-745-6258

CCOP - Columbus *Recruiting*
Columbus,  Ohio,  43206
United States
Recruiting J.  Kuebler 614-488-2118

MBCCOP - Howard University Cancer Center *Recruiting*
Washington D.C.,  District of Columbia,  20060
United States
Recruiting Lucile  Adams-Campbell 202-806-7697

Foundation for Cancer Research and Education *Recruiting*
Phoenix,  Arizona,  85013
United States
Recruiting David  Brachman 602-274-4484

Veterans Affairs Medical Center - Palo Alto *Recruiting*
Palo Alto,  California,  94304-1290
United States
Recruiting Harlan  Pinto 650-493-5000 ext. 4948

Winship Cancer Institute of Emory University *Recruiting*
Atlanta,  Georgia,  30322
United States
Recruiting William  Wood 404-778-5180

Veterans Affairs Medical Center - Tennessee Valley Healthcare System - Nashville Campus *Recruiting*
Nashville,  Tennessee,  37212-2637
United States
Recruiting Kenneth  Hande 615-327-4751

CCOP - Duluth *Recruiting*
Duluth,  Minnesota,  55805
United States
Recruiting Robert  Dalton 218-786-8364

City of Hope Comprehensive Cancer Center *Recruiting*
Duarte,  California,  91010-3000
United States
Recruiting Theodore  Krontiris 626-301-8164

CCOP - Northern Indiana CR Consortium *Recruiting*
South Bend,  Indiana,  46601
United States
Recruiting Rafat  Ansari 574-284-7977

Veterans Affairs Medical Center - Atlanta (Decatur) *Recruiting*
Decatur,  Georgia,  30033
United States
Recruiting Maria  Amarante Ribeiro 404-728-7680

Veterans Affairs Medical Center - Pittsburgh *Recruiting*
Pittsburgh,  Pennsylvania,  15240
United States
Recruiting Timothy  Carlos 412-688-6248

Dixie Regional Medical Center *Recruiting*
St. George,  Utah,  84770
United States
Recruiting Ray  Richards 801-688-4175

MBCCOP - University of New Mexico HSC *Recruiting*
Albuquerque,  New Mexico,  87131
United States
Recruiting Cynthia  Cathcart 505-272-5688

University of Alabama at Birmingham Comprehensive Cancer Center *Recruiting*
Birmingham,  Alabama,  35294-3300
United States
Recruiting Carla  Falkson 205-975-2691

CCOP - Ochsner *Recruiting*
New Orleans,  Louisiana,  70121
United States
Recruiting Carl  Kardinal 504-842-3910

Des Moines General Hospital *Recruiting*
Des Moines,  Iowa,  50309
United States
Recruiting Roscoe  Morton 515-247-3121

Robert H. Lurie Comprehensive Cancer Center at Northwestern University *Recruiting*
Chicago,  Illinois,  60611
United States
Recruiting Al  Benson 312-695-1382

CCOP - Southern Nevada Cancer Research Foundation *Recruiting*
Las Vegas,  Nevada,  89106
United States
Recruiting John  Ellerton 702-384-0013

Albert Einstein Clinical Cancer Center *Recruiting*
Bronx,  New York,  10461
United States
Recruiting Joseph  Sparano 718-904-2555

CCOP - Scott and White Hospital *Recruiting*
Temple,  Texas,  76508
United States
Recruiting Lucas  Wong 254-724-7048

Drexel University Hospital *Recruiting*
Philadelphia,  Pennsylvania,  19102-1192
United States
Recruiting Pamela  Crilley 215-762-8547

Veterans Affairs Medical Center - Omaha *Recruiting*
Omaha,  Nebraska,  68105
United States
Recruiting James  Mailliard 402-280-5274

Hillman Cancer Center at University of Pittsburgh Cancer Institute *Recruiting*
Pittsburgh,  Pennsylvania,  15236
United States
Recruiting John  Kirkwood 412-692-4724

Monmouth Medical Center *Recruiting*
Long Branch,  New Jersey,  07740-6395
United States
Recruiting Smitha  Gollamudi 732-923-6890

Veterans Affairs Medical Center - Indianapolis (Roudebush) *Recruiting*
Indianapolis,  Indiana,  46202
United States
Recruiting Patrick  Loehrer 317-554-0000

Penn State Cancer Institute at Milton S. Hershey Medical Center *Recruiting*
Hershey,  Pennsylvania,  17033-0850
United States
Recruiting Witold  Rybka 717-531-1050

Pretoria Academic Hospital *Recruiting*
Pretoria,  ,  0001
South Africa
Recruiting Coenraad  Slabber 27-12-354-1054

John Stoddard Cancer Center at Iowa Methodist Medical Center *Recruiting*
Des Moines,  Iowa,  50309
United States
Recruiting Roscoe  Morton 515-241-4245

CCOP - Northern New Jersey *Recruiting*
Hackensack,  New Jersey,  07601
United States
Recruiting Richard  Rosenbluth 201-996-5917

Veterans Affairs Medical Center - Brooklyn *Recruiting*
Brooklyn,  New York,  11209
United States
Recruiting Andrea  Wiesel Leaf 718-630-3691

MBCCOP - San Juan *Recruiting*
San Juan,  ,  00921-3201
Puerto Rico
Recruiting Luis  Baez-Diaz 787-641-3693

CCOP - Evanston *Recruiting*
Evanston,  Illinois,  60201
United States
Recruiting Gershon  Locker 847-570-2518

Abramson Cancer Center at University of Pennsylvania Medical Center *Recruiting*
Philadelphia,  Pennsylvania,  19104
United States
Recruiting Daniel  Haller 215-662-6318

CCOP - Central Illinois *Recruiting*
Decatur,  Illinois,  62526
United States
Recruiting James  Wade 217-876-6617

Veterans Affairs Medical Center - New York *Recruiting*
New York City,  New York,  10010
United States
Recruiting Howard  Hochster 212-652-1912

Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute *Recruiting*
Boston,  Massachusetts,  02115
United States
Recruiting Annick  Van den Abbeele 617-632-3223

Norris Cotton Cancer Center at Dartmouth Medical School *Recruiting*
Lebanon,  New Hampshire,  03756-0002
United States
Recruiting Camilo  Fadul 603-650-6312

Midlands Cancer Center at Midlands Community Hospital *Recruiting*
Papillion,  Nebraska,  68128-4157
United States
Recruiting James  Mailliard 402-593-3000

Veterans Affairs Medical Center - Lakeside Chicago *Recruiting*
Chicago,  Illinois,  60611-4494
United States
Recruiting Timothy  Kuzel 312-469-3748

CCOP - Oklahoma *Recruiting*
Tulsa,  Oklahoma,  74136
United States
Recruiting James  Lockhart 918-491-5878

MetroHealth Medical Center *Recruiting*
Cleveland,  Ohio,  44109
United States
Recruiting Edward  Mansour 216-778-4394

CCOP - Carle Cancer Center *Recruiting*
Urbana,  Illinois,  61801
United States
Recruiting Kendrith  Rowland 217-383-4083

Cleveland Clinic Taussig Cancer Center *Recruiting*
Cleveland,  Ohio,  44195
United States
Recruiting Robert  Dreicer 216-445-4623

CCOP - Iowa Oncology Research Association *Recruiting*
Des Moines,  Iowa,  50309-1016
United States
Recruiting Roscoe  Morton 515-244-7586

West Michigan Cancer Center *Recruiting*
Kalamazoo,  Michigan,  49007
United States
Recruiting Contact  Person 616-373-7488

CCOP - Cedar Rapids Oncology Project *Recruiting*
Cedar Rapids,  Iowa,  52403-1206
United States
Recruiting Martin  Wiesenfeld 319-363-8303

CCOP - St. Vincent Hospital Cancer Center, Green Bay *Recruiting*
Green Bay,  Wisconsin,  54307-3453
United States
Recruiting Gerald  Bayer 920-433-8889

CCOP - Marshfield Clinic Research Foundation *Recruiting*
Marshfield,  Wisconsin,  54449
United States
Recruiting Tarit  Banerjee 715-387-5134

Westmead Hospital *Recruiting*
Westmead,  New South Wales,  2145
Australia
Recruiting Richard  Kefford 61-2-9845-6033

Cancer Institute of New Jersey *Recruiting*
New Brunswick,  New Jersey,  08903
United States
Recruiting Joseph  Aisner 732-235-7464

Indiana University Cancer Center *Recruiting*
Indianapolis,  Indiana,  46202-5289
United States
Recruiting Patrick  Loehrer 317-278-7418

CCOP - Wichita *Recruiting*
Wichita,  Kansas,  67214-3882
United States
Recruiting Shaker  Dakhil 316-268-5784

Tufts - New England Medical Center *Recruiting*
Boston,  Massachusetts,  02111
United States
Recruiting John  Erban 617-636-5147

NYU School of Medicine's Kaplan Comprehensive Cancer Center *Recruiting*
New York City,  New York,  10016
United States
Recruiting Howard  Hochster 212-652-1912

Burgess Health Center *Recruiting*
Onawa,  Iowa,  51040
United States
Recruiting James  Mailliard 712-423-2311

Cancer Institute at Oregon Health and Science University *Recruiting*
Portland,  Oregon,  97239-3098
United States
Recruiting John  Holland 503-494-8759

Veterans Affairs Medical Center - San Juan *Recruiting*
San Juan,  ,  00927-5800
Puerto Rico
Recruiting Luis  Baez-Diaz 787-641-3693

Utah Valley Regional Medical Center - Provo *Recruiting*
Provo,  Utah,  84604
United States
Recruiting Tarlton  Blair 801-373-7850 ext. 2480

CCOP - Christiana Care Health Services *Recruiting*
Newark,  Delaware,  19713
United States
Recruiting Stephen  Grubbs 302-623-4100

CCOP - Columbia River Oncology Program *Recruiting*
Portland,  Oregon,  97225
United States
Recruiting Keith  Lanier 503-216-6260

San Juan City Hospital *Recruiting*
San Juan,  ,  00936-7344
Puerto Rico
Recruiting Luis  Baez-Diaz 787-641-3693

Veterans Affairs Medical Center - Miami *Recruiting*
Miami,  Florida,  33125
United States
Recruiting Niramol  Savaraj 305-324-3143

Instituto de Enfermedades Neoplasicas *Recruiting*
Lima,  ,  34
Peru
Recruiting Carlos  Vallejos-Sologuren 51-14-499-137

Stanford Cancer Center at Stanford University Medical Center *Recruiting*
Stanford,  California,  94305-5216
United States
Recruiting Harlan  Pinto 650-725-9057

CCOP - Illinois Oncology Research Association *Recruiting*
Peoria,  Illinois,  61602
United States
Recruiting John  Kugler 309-636-3605

CCOP - Merit Care Hospital *Recruiting*
Fargo,  North Dakota,  58122
United States
Recruiting Preston  Steen 701-234-6161

University of Wisconsin Comprehensive Cancer Center *Recruiting*
Madison,  Wisconsin,  53792-0001
United States
Recruiting James  Stewart 608-265-8131

CCOP - Metro-Minnesota *Recruiting*
St. Louis Park,  Minnesota,  55416
United States
Recruiting Patrick  Flynn 952-993-15175

Mayo Clinic Cancer Center *Recruiting*
Rochester,  Minnesota,  55905-0001
United States
Recruiting Michael  Haddock 507-284-2669

CCOP - Toledo Community Hospital *Recruiting*
Toledo,  Ohio,  43623-3456
United States
Recruiting Paul  Schaefer 419-843-6147

MBCCOP - LSU Health Sciences Center *Recruiting*
New Orleans,  Louisiana,  70112
United States
Recruiting Jill  Gilbert 504-568-5136

Mercy Cancer Center at Mercy Medical Center-Des Moines *Recruiting*
Des Moines,  Iowa,  50314
United States
Recruiting Roscoe  Morton 515-247-3121

CCOP - Geisinger Clinic and Medical Center *Recruiting*
Danville,  Pennsylvania,  17822-2001
United States
Recruiting Suresh  Nair 570-271-6413

Veterans Affairs Medical Center - Minneapolis *Recruiting*
Minneapolis,  Minnesota,  55417-2399
United States
Recruiting Markus  Gapany 612-725-2000 ext. 3459

McKay-Dee Hospital Center *Recruiting*
Ogden,  Utah,  84403
United States
Recruiting Contact  Person 801-627-2800

Veterans Affairs Medical Center - Tampa (Haley) *Recruiting*
Tampa,  Florida,  33612
United States
Recruiting Julie  Kish 813-972-2000

CCOP - Colorado Cancer Research Program, Incorporated *Recruiting*
Denver,  Colorado,  80224
United States
Recruiting Eduardo  Pajon 303-777-2663

CCOP - MainLine Health *Recruiting*
Wynnewood,  Pennsylvania,  19096
United States
Recruiting Paul  Gilman 610-645-2057

CCOP - Michigan Cancer Research Consortium *Recruiting*
Ann Arbor,  Michigan,  48106
United States
Recruiting Philip  Stella 734-712-2000

Cottonwood Hospital Medical Center *Recruiting*
Murray,  Utah,  84107
United States
Recruiting Contact  Person 801-314-5300

University of Minnesota Cancer Center *Recruiting*
Minneapolis,  Minnesota,  55455
United States
Recruiting George  Adams 612-625-2410

Veterans Affairs Medical Center - Milwaukee (Zablocki) *Recruiting*
Milwaukee,  Wisconsin,  53295
United States
Recruiting Mohammed  Raheem 414-384-2000


Additional Information:
Study ID Numbers:
  CDR0000069111;  RTOG-S-0132,ACRIN-6665,RTOG-DEV-1055,ECOG-RTOG-R0132
Study Start Date: 
Record last reviewed: November 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00028002

Other Gastrointestinal Stromal Tumor Studies:
1. Brostallicin in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma

2. Imatinib Mesylate (Gleevec; STI571) in Treating Patients With Primary Gastrointestinal Stromal Tumor That Has Been Completely Removed by Surgery

3. Imatinib Mesylate in Treating Patients With Primary or Recurrent Malignant Gastrointestinal Stromal Tumor

4. Vaccine Therapy and Sargramostim in Treating Patients With Sarcoma or Brain Tumor

5. Comparison of Two Different Doses of STI571 in Treating Patients With Metastatic or Unresectable Gastrointestinal Stromal Tumor

Related Studies:

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Other Arlington Heights Clinical Trials

Imatinib Mesylate in Treating Patients With Primary or Recurrent Malignant Gastrointestinal Stromal Tumor

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