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Home > "I" Clinical Trials Conditions > Idiopathic Pulmonary Fibrosis: a Case-control Study  Idiopathic Pulmonary Fibrosis: a Case-control Study
Idiopathic Pulmonary Fibrosis: a Case-control Study
For Condition: Pulmonary Fibrosis,Lung Diseases,Lung Diseases, Interstitial
Status: Completed
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: To determine risk factors for idiopathic pulmonary fibrosis.
Details: BACKGROUND: Idiopathic pulmonary fibrosis is a progressive and generally fatal disease that causes fibrosis of the pulmonary interstitium. While many environmental agents cause diseases clinically similar, the etiology of idiopathic pulmonary fibrosis suggests that environmental agents could incite the tissue injury that results in the disease; furthermore, host characteristics could have an important role in determining the magnitude of the host response to the agent initiating injury. DESIGN NARRATIVE: In this case control study, cases were ascertained at the multiple collaborating centers and controls were identified by telephone screening. A telephone interview was conducted to collect information needed to test hypotheses concerning cigarette smoking, occupational exposure, indoor exposures, other environmental factors, and host factors. To limit disease misclassification, two pathologists experienced with interstitial diseases of the lung reviewed histopathological material from all cases to exclude entities other than interstitial lung fibrosis and to fully characterize the cases clinically. The mortality of this large series of cases was also described.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Male
Protocol Entry Criteria: No eligibility criteria
Total Enrollment:
Location and Contact Information:
Additional Information:
Study ID Numbers: 2018;
Study Start Date: July 1989
Record last reviewed: May 2000
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00005295
Other Lung Diseases, Interstitial Studies:
1. Oral Pirfenidone for the Pulmonary Fibrosis of Hermansky-Pudlak Syndrome
2. An Open-Label Study of the Safety of Interferon gamma-1b in Patients with IPF
3. Segmental Bronchoalveolar Lavage
4. Idiopathic Pulmonary Fibrosis
5. Clinical and Basic Investigations into Hermansky-Pudlak Syndrome
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Idiopathic Pulmonary Fibrosis: a Case-control Study
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