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Home > "I" Clinical Trials Conditions > Identification of Genes Associated with Lung Disease in Patients with Rheumatoid Arthritis  Identification of Genes Associated with Lung Disease in Patients with Rheumatoid Arthritis
Identification of Genes Associated with Lung Disease in Patients with Rheumatoid Arthritis
For Condition: Healthy,Pulmonary Fibrosis,Rheumatoid Arthritis
Status: Recruiting
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: Pulmonary fibrosis (PF) is a condition in which the lungs of a patient become scarred and fibrous. It has been known to occur in as many as 40% of patients diagnosed with rheumatoid arthritis (RA). The cause of the pulmonary fibrosis in patients with RA is unknown. Data gathered from previous research studies suggest that genetics may play a role in the development of PF in patients with rheumatoid arthritis. However, the actual genetic factors involved in the disease process have not been identified. The goal of this study is to identify the genetic markers in patients with pulmonary fibrosis and rheumatoid arthritis.
Details: Pulmonary fibrosis that develops within a subpopulation of patients with rheumatoid arthritis is a disorder of unknown etiology. Although previous reports suggest that some individuals with rheumatoid arthritis have a genetic predisposition to the development of fibrotic lung disease, genetic factors have not been clearly identified. It is the intent of this clinical protocol to identify genetic polymorphisms in individuals with pulmonary fibrosis and rheumatoid arthritis.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Individuals 21 years of age or older with any of the following: RA (based on 1987 American College of Rheumatology Revised Criteria for the Classification of RA) with PF (biopsy-proven), or RA-only, or Biopsy-proven idiopathic PF-only, or Healthy research volunteers. EXCLUSION CRITERIA: Individuals with any of the following: Inhalational exposure to fibrogenic fibers or dusts (e.g., asbestos, silica, coal, beryllium). Chronic pulmonary disorders other than pulmonary fibrosis. Other collagen vascular disorders (e.g., systemic lupus erythematosus, scleroderma, polymyositis, mixed connective tissue disease). Non-rheumatoid arthritis. Viral infections associated with PF (e.g., hepatitis B, hepatitis C, human immunodeficiency virus). Pregnancy.
Total Enrollment: 400
Location and Contact Information:
National Heart, Lung and Blood Institute (NHLBI) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 990069; 99-H-0069
Study Start Date: March 21, 1999
Record last reviewed: March 18, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001885
Other Rheumatoid Arthritis Studies:
1. Lung Disease Associated with Rheumatoid Arthritis
2. Consistency of Traditional Chinese Medicine Diagnoses and Herbal Prescriptions for Rheumatoid Arthritis
3. Infliximab for the Treatment of Early Rheumatoid Arthritis
4. Effects of MEDI-522 On Disease Activity and Progression of Joint Damage in Patients with Active Rheumatoid Arthritis Suboptimally Responding to Methotrexate
5. Prevention of Arthritis-Related Work Disability
Related Studies:
Other Rheumatoid Arthritis Clinical Trials
Other Maryland Clinical Trials
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Identification of Genes Associated with Lung Disease in Patients with Rheumatoid Arthritis
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