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Home > "H" Clinical Trials Conditions > Hypertension in Black Americans: A Life Course Approach Hypertension in Black Americans: A Life Course Approach
Hypertension in Black Americans: A Life Course Approach
For Condition: Cardiovascular Diseases,Hypertension,Heart Diseases
Status: No longer recruiting
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: To investigate the relationship between life-stress factors associated with socioeconomic conditions and hypertension.
Details: BACKGROUND: Increasingly, researchers are recognizing that risk for cardiovascular disease (CVD) in adulthood is rooted in the social and material life conditions of childhood, and that these childhood conditions may predict risk for CVD above and beyond traditional adulthood indicators of socioeconomic status (SES) such as education, occupation or income. Nowhere is this life course perspective on CVD risk more important than in the case of African Americans, especially the generation that "came of age" in the U.S. South in the late 1950s and 1960s, the peak years of the modern Civil Rights Movement. While some African American members of this age cohort were able to take advantage of the new opportunities for economic advancement, some others were not, resulting thereafter in different life course trajectories of exposure to social and economic hardship. The relationship between variations in these social and economic life course trajectories, and CVD risk (specifically hypertension) in adulthood, has not been investigated in African Americans. DESIGN NARRATIVE: The study uses the Pitt County, (NC) cohort, a community sample of African Americans (N=1784, 66 percent female, 80 percent response rate) who were between 25-50 years of age at baseline in 1988. Normotensives in the baseline sample were re-examined in 1993 (N=1195, 66 percent female, 85 percent response rate). In addition to measuring blood pressure, extensive data on psychosocial, behavioral, and anthropometric characteristics were obtained at both times. The study re-examines the original cohort in 2001; the anticipated sample size is 1142 individuals (717 women and 425 men). Starting from age 20, respondents' reported exposure to three domains of socioenvironmental stressors will be assessed: (1) adverse socioeconomic conditions; (2) low levels of social integration; and (3) racial discrimination. Taken individually, and then collectively, the greater the cumulative life course exposure to these stressors, the greater the risk for adult hypertension is expected to be. The primary analyses will focus on the relationship between pre-1988 exposures and 1988 blood pressure status (retrospective analyses), and the relationship between pre-1988 exposures and changes in blood pressure status between 1988 and 2001(prospective analyses).
Eligibility:
Study Type: Observational, Natural History, Longitudinal, Defined Population, Retrospective Study
Minimum Age/Maximum Age: 25 Years/50 Years
Genders: Both
Protocol Entry Criteria: No eligibility criteria
Total Enrollment:
Location and Contact Information:
Overall Study Official:
ShermanJames, , Duke University
Additional Information:
Study ID Numbers: 933;
Study Start Date: August 2000
Record last reviewed: February 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00006408
Other Cardiovascular Diseases Studies:
1. Physical Activity and Cardiovascular Risk in Black Girls
2. Hypertension Detection and Follow-up Program (HDFP)
3. Epidemiology of Carotid Artery Atherosclerosis in Youth
4. Family Blood Pressure Program - SAPPHIRe Network
5. Epidemiology of Coronary Calcification in the Elderly
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Hypertension in Black Americans: A Life Course Approach
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