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Hydroxychloroquine in Treating Patients With Newly Diagnosed Chronic Graft-Versus-Host Disease Clinical Trials Facts presented on Clinical Trials Search isn't designed to be a substitute for proven healthcare advice, calls or treatment using a real mD. We aren't mDs. Always confer with your physician on Hydroxychloroquine in Treating Patients With Newly Diagnosed Chronic Graft-Versus-Host Disease conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Hydroxychloroquine in Treating Patients With Newly Diagnosed Chronic Graft-Versus-Host Disease Clinical research trials and Hydroxychloroquine in Treating Patients With Newly Diagnosed Chronic Graft-Versus-Host Disease healthcare trials happen in a lot of of localities across the United States of America. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally measure the potency of new drugs. The aim of the studies / undertakings is to answer particular human medical questions. Clinical trials are a popular manner for doctors, government agencies, and private sector corporations to discover remedies for all kinds of circumstances, such as Hydroxychloroquine in Treating Patients With Newly Diagnosed Chronic Graft-Versus-Host Disease. Hydroxychloroquine in Treating Patients With Newly Diagnosed Chronic Graft-Versus-Host Disease Clinical Trials and other clinical trials allow volunteers to get healthcare treatment alternatives before they are available to the general public. Most times the participants receive treatment for without cost, and occasionally they are paid for their time. Sometimes there is a cost for a Hydroxychloroquine in Treating Patients With Newly Diagnosed Chronic Graft-Versus-Host Disease clinical trial. Human subjects often receive the most effective healthcare possible for their Hydroxychloroquine in Treating Patients With Newly Diagnosed Chronic Graft-Versus-Host Disease condition. Risks are a reality, nonetheless, and may include more or frequent dr. calls, healthcare hazards (perhaps life-threatening), and/or the treatment being ineffective. Trials are federally governed with rigorous guidelines to protect clinical trials subjects.
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Home > "H" Clinical Trials Conditions > Hydroxychloroquine in Treating Patients With Newly Diagnosed Chronic Graft-Versus-Host Disease  Hydroxychloroquine in Treating Patients With Newly Diagnosed Chronic Graft-Versus-Host Disease
Hydroxychloroquine in Treating Patients With Newly Diagnosed Chronic Graft-Versus-Host Disease
For Condition: Graft Versus Host Disease
Status: Recruiting
Sponsor(s): Children's Oncology Group , National Cancer Institute (NCI)
Synopsis: RATIONALE: Hydroxychloroquine may decrease the immune response and be effective in treating chronic graft-versus-host disease. It is not yet known if standard therapy for graft-versus-host disease is more effective with or without hydroxychloroquine. PURPOSE: Randomizedphase III trial to compare the effectiveness of standard therapy alone with that of standard therapy plus hydroxychloroquine in treating patients who have newly diagnosed chronic graft-versus-host disease.
Details: OBJECTIVES: - Compare the efficacy of prednisone and cyclosporine with or without hydroxychloroquine in patients with newly diagnosed extensive chronic graft-versus-host disease (GVHD). - Compare the event-free and overall survival in patients treated with these regimens. - Compare the health-related quality of life, including longitudinal change in and magnitude of persistent disability, in patients treated with these regimens. - Correlate cytokine levels and T-helper cell subtypes with chronic GVHD activity and response in patients treated with these regimens. - Correlate whole blood hydroxychloroquine levels with response and toxicity in patients treated with these regimens. OUTLINE: This is a randomized, placebo-controlled, double-blind, multicenter study. Patients are randomized to one of two treatment arms. - Arm I: Patients receive standard therapy comprising prednisone orally or IV 2-3 times daily or every other day and cyclosporine orally or IV twice daily (patients already receiving tacrolimus continue to receive tacrolimus orally or IV twice daily instead of cyclosporine). Patients also receive oral hydroxychloroquine twice daily. - Arm II: Patients receive standard therapy as in arm I and oral placebo twice daily. In both arms, treatment continues for 9 months in the absence of disease progression or unacceptable toxicity. Patients with no response after 6 months of therapy are taken off study. Quality of life is assessed at baseline, 1 month, 9 months, and then at 1 year. Patients are followed every month for 3 months, at 9 months, and then at 1 year. PROJECTED ACCRUAL: A total of 232 patients (116 per treatment arm) will be accrued for this study within 3.6 years.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: 1 Year/29 Years
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically confirmed* newly diagnosed extensive chronic graft-versus-host disease (GVHD) of at least 1 organ system (e.g., lip, skin, or liver), documented by 1 of the following: - Generalized skin involvement of at least 50% of body surface area - Localized skin involvement and/or liver dysfunction with at least 1 of the following: - Liver histology showing chronic aggressive hepatitis, bridging necrosis, or cirrhosis - Eye involvement (Schirmer's test with less than 5 mm wetting) - Involvement of minor salivary glands or oral mucosa on lip biopsy - Involvement of any other target organs - Involvement of at least 2 target organs - Prior allogeneic bone marrow, peripheral blood stem cell, or cord blood transplantation from a family member or unrelated donor for malignancy - No recurrence of malignancy after transplantation NOTE: *Histologic confirmation may be "consistent with GVHD" or "diagnostic of GVHD" PATIENT CHARACTERISTICS: Age: - 1 to 29 Performance status: - Lansky 50-100% OR - Karnofsky 50-100% Life expectancy: - At least 2 months Hematopoietic: - Absolute neutrophil count at least 1,000/mm^3 Hepatic: - See Disease Characteristics Renal: - Creatinine less than 1.5 times upper limit of normal OR - Creatinine clearance at least 60 mL/min Other: - Not pregnant - Negative pregnancy test - Fertile patients must use effective contraception during and for 3 months after study participation - No lysosomal storage disorder - No uncontrolled infection (e.g., persistent bacterial, fungal, or viral infection despite appropriate antimicrobial therapy) - No G6PD deficiency - No history of psoriasis or porphyria - No hypersensitivity to 4-aminoquinolines - No prior retinal or visual field changes due to 4-aminoquinolines PRIOR CONCURRENT THERAPY: Biologic therapy: - See Disease Characteristics Chemotherapy: - Not specified Endocrine therapy: - Concurrent steroids for treatment and/or prophylaxis of acute GVHD allowed if prednisone dose is no greater than 1 mg/kg/day (or equivalent) - Concurrent topical steroids allowed Radiotherapy: - Not specified Surgery: - Not specified Other: - No prior treatment for chronic GVHD except the following: - Topical treatment - Adjustments of cyclosporine or tacrolimus doses - Up to 25% increase in steroid dose (only if done as a reversal of a recent taper) - Concurrent cyclosporine or tacrolimus allowed - No other concurrent systemic or topical immunosuppressants
Total Enrollment:
Location and Contact Information:
Overall Study Official:
AndrewGilman, Study Chair, Children's Mercy Hospital
Deaconess Medical Center *Recruiting*
Spokane, Washington, 99210-0248
United States
Recruiting Steven Bergstrom 509-473-7012
Markey Cancer Center at University of Kentucky Chandler Medical Center *Recruiting*
Lexington, Kentucky, 40536-0084
United States
Recruiting Donna Reece 859-257-4500
Mayo Clinic Cancer Center *Recruiting*
Rochester, Minnesota, 55905
United States
Recruiting Peter Anderson 507-284-2511
Children's Hospital of Michigan *Recruiting*
Detroit, Michigan, 48201
United States
Recruiting Esteban Abella 313-745-5515
Cancer Center at Hackensack University Medical Center *Recruiting*
Hackensack, New Jersey, 07601
United States
Recruiting Joel Brochstein 201-996-5600
New York Medical College *Recruiting*
Valhalla, New York, 10595
United States
Recruiting M. Ozkaynak 914-493-7997
Presbyterian-St Luke's Medical Center *Recruiting*
Denver, Colorado, 80218
United States
Recruiting Edward Arenson 303-839-6000
Washington University Medical Center *Recruiting*
St. Louis, Missouri, 63110
United States
Recruiting Robert Hayashi 314-454-4118
University of Michigan Comprehensive Cancer Center *Recruiting*
Ann Arbor, Michigan, 48109-0914
United States
Recruiting Raymond Hutchinson 734-936-8785
CCOP - Columbia River Oncology Program *Recruiting*
Portland, Oregon, 97225
United States
Recruiting Keith Lanier 503-216-6260
University of Texas Health Science Center at San Antonio *Recruiting*
San Antonio, Texas, 78207
United States
Recruiting Paul Thomas 210-704-3405
Stanford Cancer Center at Stanford University Medical Center *Recruiting*
Stanford, California, 94305-5208
United States
Recruiting Michael Amylon 650-723-5535
Indiana University Cancer Center *Recruiting*
Indianapolis, Indiana, 46202-5289
United States
Recruiting Robert Fallon 317-274-8784
Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center *Recruiting*
Los Angeles, California, 90048
United States
Recruiting Michael Lill 310-423-2997
City of Hope Comprehensive Cancer Center *Recruiting*
Duarte, California, 91010-3000
United States
Recruiting Joseph Rosenthal 626-359-8111
Floating Hospital for Children *Recruiting*
Boston, Massachusetts, 02111
United States
Recruiting Cynthia Kretschmar 617-636-5535
Herbert Irving Comprehensive Cancer Center at Columbia University *Recruiting*
New York City, New York, 10032
United States
Recruiting Mitchell Cairo 212-305-8316
Doernbecher Children's Hospital at Oregon Health & Science University *Recruiting*
Portland, Oregon, 97239-3098
United States
Recruiting H. Nicholson 503-494-1543
Holden Comprehensive Cancer Center at University of Iowa *Recruiting*
Iowa City, Iowa, 52242-1009
United States
Recruiting Raymond Tannous 319-356-1905
Medical College of Georgia Comprehensive Cancer Center *Recruiting*
Augusta, Georgia, 30912-4000
United States
Recruiting Hernan Sabio 706-721-3626
Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas *Recruiting*
Dallas, Texas, 75390-9063
United States
Recruiting Victor Aquino 214-648-3074
St. Jude Children's Research Hospital *Recruiting*
Memphis, Tennessee, 38105-2794
United States
Recruiting Rupert Handgretinger 901-495-4496
University of Arkansas for Medical Sciences *Recruiting*
Little Rock, Arkansas, 72205
United States
Recruiting Joan Morris 501-320-1494
Kosair Children's Hospital *Recruiting*
Louisville, Kentucky, 40232
United States
Recruiting Roger Herzig 502-629-6000
Rainbow Babies and Children's Hospital *Recruiting*
Cleveland, Ohio, 44106
United States
Recruiting Michael Nieder 216-844-3345
Baylor College of Medicine *Recruiting*
Houston, Texas, 77030-2399
United States
Recruiting Ingrid Kuehnle 832-824-4758
CCOP - St. Vincent Hospital Cancer Center, Green Bay *Recruiting*
Green Bay, Wisconsin, 54301
United States
Recruiting Thomas Saphner 920-432-5134
Hollings Cancer Center at Medical University of South Carolina *Recruiting*
Charleston, South Carolina, 29425
United States
Recruiting Jacqueline Kraveka 843-792-2957
Swiss Pediatric Oncology Group Bern *Recruiting*
Bern, , CH 3010
Switzerland
Recruiting Kurt Leibundgut 41-31-632-9337
University of Texas - MD Anderson Cancer Center *Recruiting*
Houston, Texas, 77030-4009
United States
Recruiting Ka Chan 713-792-3326
All Children's Hospital *Recruiting*
St. Petersburg, Florida, 33701
United States
Recruiting Hans-Christoph Rossbach 813-892-4176
Sydney Children's Hospital *Recruiting*
Randwick, New South Wales, 2031
Australia
Recruiting Marcus Vowels 61-2-9382-1733
UCSF Comprehensive Cancer Center *Recruiting*
San Francisco, California, 94115
United States
Recruiting Katherine Matthay 415-353-9510
Miami Children's Hospital *Recruiting*
Miami, Florida, 33155-4069
United States
Recruiting John Fort 305-662-8360
Shands Cancer Center at the University of Florida Health Science Center *Recruiting*
Gainesville, Florida, 32610-0342
United States
Recruiting John Graham-Pole 352-392-5633
Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center *Recruiting*
Nashville, Tennessee, 37232-6310
United States
Recruiting Haydar Frangoul 615-936-1762
Children's Hospital and Research Center at Oakland *Recruiting*
Oakland, California, 94609
United States
Recruiting Mark Walters 510-428-3374
Pediatric Hematology and Oncology Associates of South Texas, PLLC *Recruiting*
San Antonio, Texas, 78229
United States
Recruiting Guy Grayson 210-614-4011
Schneider Children's Hospital *Recruiting*
New Hyde Park, New York, 11042
United States
Recruiting Arlene Redner 718-470-3460
Arizona Cancer Center at University of Arizona Health Sciences Center *Recruiting*
Tucson, Arizona, 85724
United States
Recruiting Michael Graham 520-626-6044
Maine Children's Cancer Program *Recruiting*
Scarborough, Maine, 04074-9308
United States
Recruiting Craig Hurwitz 207-885-7565
Children's Hospital of Denver *Recruiting*
Denver, Colorado, 80218-1088
United States
Recruiting Roger Giller 303-861-6892
Children's Memorial Hospital - Chicago *Recruiting*
Chicago, Illinois, 60614
United States
Recruiting Morris Kletzel 773-880-3265
UNMC Eppley Cancer Center at the University of Nebraska Medical Center *Recruiting*
Omaha, Nebraska, 68198-3330
United States
Recruiting Alfred Grovas 402-559-7257
Inova Fairfax Hospital *Recruiting*
Falls Church, Virginia, 22042-3300
United States
Recruiting Eva Wallace-Perdahl 703-698-1110
Methodist Cancer Center at Methodist Specialty and Transplant Hospital *Recruiting*
St. Louis, Missouri, 63104
United States
Recruiting Dennis O'Connor 314-577-5638
Starship Children's Hospital *Recruiting*
Auckland, ,
New Zealand
Recruiting Lochie Teague 64-9-307-4949 ext. 6295
Medical College of Georgia *Recruiting*
Augusta, Georgia, 30912-3730
United States
Recruiting Shafqat Shah 706-721-3626
Children's Hospitals and Clinics - Minneapolis *Recruiting*
Minneapolis, Minnesota, 55404
United States
Recruiting Maura O'Leary 612-813-5940
Children's National Medical Center *Recruiting*
Washington D.C., District of Columbia, 20010-2970
United States
Recruiting Naynesh Kamani 202-884-2800
Cancer Institute at Oregon Health and Science University *Recruiting*
Portland, Oregon, 97239-3098
United States
Recruiting F. Johnson 503-494-1617
Children's Hospital and Health Center, San Diego *Recruiting*
San Diego, California, 92123-4282
United States
Recruiting Richard Kadota 858-966-5811
Memorial Sloan-Kettering Cancer Center *Recruiting*
New York City, New York, 10021
United States
Recruiting Farid Boulad 212-639-6684
San Jorge Childrens Hospital *Recruiting*
Santurce, , 00912
Puerto Rico
Recruiting Luis Clavell 787-728-1575
Spectrum Health and DeVos Children's Hospital *Recruiting*
Grand Rapids, Michigan, 49503
United States
Recruiting Daniel Pietryga 616-391-9127
CancerCare Manitoba *Recruiting*
Winnipeg, Manitoba, R3E 0V9
Canada
Recruiting Marlis Schroeder 204-787-7095
Nemours Children's Clinic *Recruiting*
Jacksonville, Florida, 32207-8482
United States
Recruiting Michael Joyce 904-390-3793
Children's Hospital at Westmead *Recruiting*
Westmead, New South Wales, 2145
Australia
Recruiting Peter Shaw 612-984-50000
Ireland Cancer Center *Recruiting*
Cleveland, Ohio, 44106-5065
United States
Recruiting Michael Nieder 216-844-3345
Duke Comprehensive Cancer Center *Recruiting*
Durham, North Carolina, 27710
United States
Recruiting Joanne Kurtzberg 919-668-1100
Royal Children's Hospital *Recruiting*
Parkville, Victoria, 3052
Australia
Recruiting Karin Tiedemann 61-3-345-6750
Alberta Children's Hospital *Recruiting*
Calgary, Alberta, T2T 5C7
Canada
Recruiting Douglas Strother 403-943-7272
Cancer Research Center of Hawaii *Recruiting*
Honolulu, Hawaii, 96813
United States
Recruiting Randal Wada 808-586-2963
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus *Recruiting*
Atlanta, Georgia, 30322
United States
Recruiting Stephen Lauer 404-315-2170
Massachusetts General Hospital Cancer Center *Recruiting*
Boston, Massachusetts, 02114
United States
Recruiting Howard Weinstein 617-724-3315
Midwest Children's Cancer Center *Recruiting*
Milwaukee, Wisconsin, 53226
United States
Recruiting James Casper 414-456-4153
University Hospital at State University of New York - Upstate Medical University *Recruiting*
Syracuse, New York, 13210
United States
Recruiting Peter Sadowitz 315-464-5294
McGill University *Recruiting*
Montreal, Quebec, H3H 1P3
Canada
Recruiting David Mitchell 514-412-4445
Southern California Permanente Medical Group *Recruiting*
Downey, California, 90242
United States
Recruiting Willye Powell 562-803-2472
Hospital for Sick Children *Recruiting*
Toronto, Ontario, M5G 1X8
Canada
Recruiting John Doyle 416-813-6200
Children's Mercy Hospital *Recruiting*
Kansas City, Missouri, 64108
United States
Recruiting Andrew Gilman 816-234-3265
James P. Wilmot Cancer Center at University of Rochester Medical Center *Recruiting*
Rochester, New York, 14642
United States
Recruiting John Horan 585-275-1941
Madigan Army Medical Center *Recruiting*
Tacoma, Washington, 98431-5000
United States
Recruiting Kelly Faucette 253-968-1864
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins *Recruiting*
Baltimore, Maryland, 21287
United States
Recruiting Allen Chen 410-614-5055
Jonsson Comprehensive Cancer Center, UCLA *Recruiting*
Los Angeles, California, 90095-1781
United States
Recruiting Theodore Moore 310-825-6708
University of Wisconsin Comprehensive Cancer Center *Recruiting*
Madison, Wisconsin, 53792-4108
United States
Recruiting Kenneth DeSantes 608-263-8563
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill *Recruiting*
Chapel Hill, North Carolina, 27599-7295
United States
Recruiting Herbert Cooper 919-966-3036
University of Minnesota Cancer Center *Recruiting*
Minneapolis, Minnesota, 55455
United States
Recruiting Norma Ramsay 612-273-2800
Kaiser Permanente Medical Center - Los Angeles *Recruiting*
Los Angeles, California, 90027
United States
Recruiting Peter Falk 323-783-5414
Princess Margaret Hospital for Children *Recruiting*
Perth, Western Australia, 6001
Australia
Recruiting David Baker 61-8-9340-8234
MBCCOP - LSU Health Sciences Center *Recruiting*
New Orleans, Louisiana, 70112
United States
Recruiting Jill Gilbert 504-568-5136
NYU School of Medicine's Kaplan Comprehensive Cancer Center *Recruiting*
New York City, New York, 10016
United States
Recruiting Sharon Gardner 212-263-8520
Cook Children's Medical Center - Fort Worth *Recruiting*
Ft. Worth, Texas, 76104
United States
Recruiting Gretchen Eames 682-885-2580
Lombardi Cancer Center at Georgetown University Medical Center *Recruiting*
Washington D.C., District of Columbia, 20007
United States
Recruiting Saul Yanovich 202-444-7253
Cardinal Glennon Children's Hospital *Recruiting*
St. Louis, Missouri, 63104
United States
Recruiting Dennis O'Connor 314-577-5638
Medical Center of Princeton *Recruiting*
Los Angeles, California, 90027-0700
United States
Recruiting Paul Gaynon 323-669-2163
CCOP - Marshfield Clinic Research Foundation *Recruiting*
Marshfield, Wisconsin, 54449
United States
Recruiting Tarit Banerjee 715-387-5134
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute *Recruiting*
Boston, Massachusetts, 02115
United States
Recruiting Leslie Lehmann 617-632-4932
Huntsman Cancer Institute *Recruiting*
Salt Lake City, Utah, 84112
United States
Recruiting Carol Bruggers 801-585-0303
Children's Hospital of Orange County *Recruiting*
Orange, California, 92868
United States
Recruiting Steven Neudorf 714-532-8636
University of Mississippi Medical Center *Recruiting*
Jackson, Mississippi, 39216-4505
United States
Recruiting Gail Megason 601-984-5220
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus *Recruiting*
Atlanta, Georgia, 30322
United States
Recruiting Stephen Lauer 404-315-2170
Swiss Pediatric Oncology Group Lausanne *Recruiting*
Lausanne, , CH 1011
Switzerland
Recruiting Maja Popovic 41-21-314-3567
Cincinnati Children's Hospital Medical Center *Recruiting*
Cincinnati, Ohio, 45229-3039
United States
Recruiting Thomas Gross 513-636-2469
Children's Hospital Los Angeles *Recruiting*
Los Angeles, California, 90027-0700
United States
Recruiting Anna Butturini 323-669-5687
Children's Hospital of Philadelphia *Recruiting*
Philadelphia, Pennsylvania, 19104
United States
Recruiting Nancy Bunin 215-590-2255
Children's Hospital of Columbus *Recruiting*
Columbus, Ohio, 43205-2696
United States
Recruiting Amanda Termuhlen 614-722-3552
Women's and Children's Hospital *Recruiting*
North Adelaide, South Australia, 5006
Australia
Recruiting Maria Kirby 61-8-8161-7411
Royal Children's Hospital *Recruiting*
Brisbane, Queensland, 4029
Australia
Recruiting Liane Lockwood 617-363-61356
Hopital Sainte Justine *Recruiting*
Montreal, Quebec, H3T 1C5
Canada
Recruiting Martin Champagne 514-345-4969
Children's Hospital of Pittsburgh *Recruiting*
Pittsburgh, Pennsylvania, 15213
United States
Recruiting Rakesh Goyal 412-692-5055
Penn State Cancer Institute at Milton S. Hershey Medical Center *Recruiting*
Hershey, Pennsylvania, 17033-0850
United States
Recruiting Kenneth Lucas 717-531-6012
Massey Cancer Center at Virginia Commonwealth University *Recruiting*
Richmond, Virginia, 23298-0037
United States
Recruiting Saul Yanovich 804-828-4360
University of Chicago Cancer Research Center *Recruiting*
Chicago, Illinois, 60601
United States
Recruiting James Nachman 773-702-6808
British Columbia Children's Hospital *Recruiting*
Vancouver, British Columbia, V6H 3V4
Canada
Recruiting Jeffrey Davis 604-875-2316
Children's Hospital of New Orleans *Recruiting*
New Orleans, Louisiana, 70118
United States
Recruiting Rajasekharan Warrier 504-568-4561
Children's Hospital and Regional Medical Center - Seattle *Recruiting*
Seattle, Washington, 98105
United States
Recruiting Douglas Hawkins 206-987-3096
Oklahoma University Medical Center at University of Oklahoma Health Sciences Center *Recruiting*
Oklahoma City, Oklahoma, 73190
United States
Recruiting George Selby 405-271-4022
CCOP - Scott and White Hospital *Recruiting*
Temple, Texas, 76508
United States
Recruiting Lucas Wong 254-724-7048
Additional Information:
Study ID Numbers: CDR0000069231; CCG-S9701,NCI-P02-0213,COG-ASCT0031
Study Start Date:
Record last reviewed: April 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00031824
Other Graft Versus Host Disease Studies:
1. Hydroxychloroquine in Treating Patients With Newly Diagnosed Chronic Graft-Versus-Host Disease
2. Compassionate Use of Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Gastrointestinal Tract
3. Sirolimus as Secondary Therapy in Treating Patients With Chronic Graft-Versus-Host Disease That Did Not Respond to Previous Systemic Treatment
4. Sargramostim in Reducing Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplantation for Hematologic Cancer or Aplastic Anemia
5. Phase I/II Study of Nonmyeloablative Allogeneic Bone Marrow Transplantation in Patients With High Risk Hemoglobinopathy
Related Studies:
Other Graft Versus Host Disease Clinical Trials
Other Missouri Clinical Trials
Other St. Louis Clinical Trials
Hydroxychloroquine in Treating Patients With Newly Diagnosed Chronic Graft-Versus-Host Disease
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