|
Hand Exercise and Upper Arm Anesthesia to Improvements Hand Function in Chronic Stroke Patients Clinical Trials Resources presented on Clinical Trials Search is not meant to be a substitute for proven health advice, calls or treatment with a real medical. We aren't mDs. Always consult your doctor on Hand Exercise and Upper Arm Anesthesia to Improvements Hand Function in Chronic Stroke Patients conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Hand Exercise and Upper Arm Anesthesia to Improvements Hand Function in Chronic Stroke Patients Clinical research trials and Hand Exercise and Upper Arm Anesthesia to Improvements Hand Function in Chronic Stroke Patients healthcare trials take place in a lot of of localities throughout the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically assess the effectiveness of new does drugs. The function of the studies / projects is to figure out specific human medical questions. Clinical trials are a popular means for doctors, government agencies, and private sector corporations to find cures for all varieties of conditions, like Hand Exercise and Upper Arm Anesthesia to Improvements Hand Function in Chronic Stroke Patients. Hand Exercise and Upper Arm Anesthesia to Improvements Hand Function in Chronic Stroke Patients Clinical Trials and other clinical trials allow volunteers to access health treatment options before they are available to the masses. Many times the subjects receive professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a Hand Exercise and Upper Arm Anesthesia to Improvements Hand Function in Chronic Stroke Patients clinical trial. Human subjects often obtain the finest healthcare possible for their Hand Exercise and Upper Arm Anesthesia to Improvements Hand Function in Chronic Stroke Patients condition. Hazards are a reality, nevertheless, and might include additional or frequent dr. calls, health hazards (potentially life-jeopardizing), and/or the treatment being uneffective. Trials are federally regulated with stern guidelines to protect clinical trials patients.
|
|
|
|
|
|
|
Home > "H" Clinical Trials Conditions > Hand Exercise and Upper Arm Anesthesia to Improvements Hand Function in Chronic Stroke Patients  Hand Exercise and Upper Arm Anesthesia to Improvements Hand Function in Chronic Stroke Patients
Hand Exercise and Upper Arm Anesthesia to Improvements Hand Function in Chronic Stroke Patients
For Condition: Cerebrovascular Accident
Status: Recruiting
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) ,
Synopsis: This study will examine the effectiveness of an experimental treatment to improve hand function in patients who have had a stroke affecting one side of the body. One of the main problems of stroke patients is difficulty using the affected hand. Most treatments focus on acute (early) intervention, although special exercises may help some chronic patients. Previous studies have indicated that combining hand exercises with anesthesia (blocking motor and sensory function) of the upper arm may improve hand movement in stroke patients, even in the chronic state. This study will examine whether the exercise plus anesthesia treatment is more beneficial for these patients over the long-term than exercise alone. Patients 18 years or older who are at least 12 months post stroke, which has affected only one side of the body, may be eligible for this study. Candidates will have a medical history and physical and neurological examinations. Participants will be randomly divided into two groups: one will practice hand exercises without upper arm anesthesia and the other will exercise with anesthesia. All patients will perform two consecutive sessions of 30-minute pinch practice-forceful pinching of the thumb and index finger. Patients in the anesthesia group will have the anesthetic injected in the lower neck. Enough anesthetic will be administered to block motor and sensory function in the shoulder and upper arm, while maintaining as much function as possible in the forearm and hand. All patients will also have transcranial magnetic stimulation (TMS) testing. For this procedure, a very brief electrical current is passed through an insulated wire coil placed on the head, producing a magnetic pulse. The pulse travels through the scalp and skull and causes small electrical currents in the outer part of the brain. During the study, the patient will be asked to make movements, do simple tasks, or tense muscles, while the electrical activity of the muscles is recorded. Patients will have four sessions at 3-week intervals and three follow-up sessions at 3 weeks, 9 weeks and 24 weeks after the testing. Follow-up evaluations will include pinch power testing, TMS, sensory function test and hand function measurement.
Details: The purpose of this protocol is to enhance our understanding of the effect of regional anesthesia of the proximal arm paired with practice on motor recovery after stroke. We plan to determine; 1) if regional anesthesia of the proximal arm (above the elbow level) paired with practice in chronic disabled stroke patients enhances an improvement of the hand motor function in addition to motor power; 2) if further enhancement of motor improvement can be achieved by repetitive trials of this intervention; and 3) how long this effect lasts.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Twelve hemispheric patients (right or left) with residual arm function who had a single monohemispheric stroke (documented by CT or MRI) at least 12 months before, without severe proprioceptive deficits, independent of previous physical therapy will be included. They should all be able to perform the training task. EXCLUSION CRITERIA: Excluded from the study will be: patients with more than one stroke; patients with large cortical, cerebellar or brainstem lesions; Patients unable to extend metacarpophalangeal (MP) joints at least 10-20 degrees, and the wrist at least 20 degrees; Patients unable to extend the wrist at least 20 degrees; Patients with substantially recovered motor function; Patients with severe depression, poor motivational capacity, or severe language disturbances, particularly of receptive nature; Patients with severe spasticity/pain; Patients with bilateral motor problems; Patients with serious cognitive deficits (defined as equivalent to a mini-mental state exam score of 20 or less); Patients severe uncontrolled medical problems (e.g. cardiovascular disease, severe rheumatoid arthritis, active joint deformity of arthritic origin, active cancer or renal disease, any kind of end-stage pulmonary or cardiovascular disease, or a deteriorated condition due to age, uncontrolled epilepsy or others); Patients with respiratory failure; Patients with friable plaques (class D disease) or a stenosis exceeding 70% in the internal carotid artery ipsilateral to the side of paresis (as assessed with ultrasonography).
Total Enrollment: 12
Location and Contact Information:
National Institute of Neurological Disorders and Stroke (NINDS) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 010002; 01-N-0002
Study Start Date: October 13, 2000
Record last reviewed: November 7, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00006414
Other Cerebrovascular Accident Studies:
1. Outcome Study ONTARGET
2. Field Administration of Stroke Therapy - Magnesium (FAST-MAG) Trial
3. ReoPro and Retavase to Treat Acute Stroke
4. Mechanisms of Human Plasticity in the Human System
5. Stroke and MI in Users of Estrogen/Progestogen
Related Studies:
Other Cerebrovascular Accident Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Hand Exercise and Upper Arm Anesthesia to Improvements Hand Function in Chronic Stroke Patients
|
|
|
|
|
|
|
|
