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Home > "G" Clinical Trials Conditions > Genetics of Obsessive-Compulsive Disorder  Genetics of Obsessive-Compulsive Disorder
Genetics of Obsessive-Compulsive Disorder
For Condition: Obsessive Compulsive Disorder
Status: Recruiting
Sponsor(s): National Institute of Mental Health (NIMH) ,
Synopsis: The purpose of this study is to identify genes that affect susceptibility to obsessive-compulsive disorder (OCD). By identifying genes that increase or decrease the risk of OCD, researchers can better understand how the condition develops and ultimately improve treatment for people with OCD. OCD is a severe, familial condition that affects approximately 2% of the population. The way OCD is inherited is not clearly understood, but researchers believe it is complex and involves multiple genes. This study will detect and localize genes that increase or decrease susceptibility to OCD. The data collected from this study will be combined with data from other research studies to determine gene linkage and association.
Details: Obsessive-compulsive disorder (OCD) is a severe, heritable condition with a lifetime prevalence of about two percent of the population. The mode of inheritance is poorly understood but is likely complex, involving multiple loci of small to major effect. Since 1995, the NIMH-IRP has been active in a multi-center family study of OCD, led by Dr. Gerald Nestadt of Johns Hopkins University, which was approved via a competitive NIMH extramural application (MH 502140). An expanded consortium of sites (including new sites at Brown and Harvard Universities) anticipates adding 300 new affected sib-pair families over the next three years. This sample will be used for linkage and association analyses. Data will be shared within this consortium of investigators studying OCD, and will eventually be combined with data obtained from a second consortium.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA Must have a diagnosis of obsessive-compulsive disorder, or be a family member (usually a parent or sibling) of someone with obsessive-compulsive disorder. Certain disorders are considered part of OCD "spectrum" disorders and often include family members with OCD. These include Tourette's Syndrome, other individuals with tics, and Trichotillomania (severe hair pulling), and other forms of repetitive behaviors. Persons with primary behavioral difficulties who do no fit with the current definitions of "OCD and OCD spectrum disorders" may not be eligible. These include compulsive shopping, gambling, or compulsive sexual behaviors.
Total Enrollment: 1500
Location and Contact Information:
National Institute of Mental Health (NIMH) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Diane Kazuba 3014968977
Additional Information:
Study ID Numbers: 960124; 96-M-0124
Study Start Date: August 22, 1996
Record last reviewed: August 13, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001548
Other Obsessive Compulsive Disorder Studies:
1. I-123 Brain Studies of Serotonin Metabolism in Psychiatric Patients and Normal Volunteers
2. Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup)
3. Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated with Streptococcal Infections
4. Developmental Phenomenology of Obsessive Compulsive Disorder and Tourette Syndrome in Children and Adolescents
5. Cortical Excitability in Obsessive-Compulsive and Related Disorders
Related Studies:
Other Obsessive Compulsive Disorder Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Genetics of Obsessive-Compulsive Disorder
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