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Home > "G" Clinical Trials Conditions > Genetics of Ankylosing Spondylitis  Genetics of Ankylosing Spondylitis
Genetics of Ankylosing Spondylitis
For Condition: Spondylitis,Ankylosing Spondylitis
Status: Recruiting
Sponsor(s): National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) ,
Synopsis: Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects the joints between the vertebrae of the spine and the joints between the spine and the pelvis. The purpose of this study is to collect information and blood samples from patients with AS and their relatives for use in genetic studies.
Details: AS is a chronic inflammatory disease that eventually causes the affected vertebrae to fuse or grow together. The cause of ankylosing spondilitis is unknown, but genetic factors seem to play a role. Risk factors include a family history of ankylosing spondylitis and male gender. This study will collect patient information and blood samples from affected and unaffected sib pairs (and when available, both parents) of 400 Caucasian families with at least two siblings fulfillling the modified New York criteria for AS. Diagnosis of AS will be verified by patient questionnaire, medical record review, and pelvic radiographs. Information from these patients will be used to search the human genome for disease-associated loci and/or genes. This study will also utilize contributions of investigators who have conducted recent clinical or genetic research in AS at 10 academic medical centers throughout North America (the North American Spondylitis Consortium, or NASC).
Eligibility:
Study Type: Observational, Natural History, Cross-Sectional, Defined Population, Retrospective/Prospective Study
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Meet modified New York criteria for ankylosing spondylitis (AS) - AS as confirmed by X-rays of sacroiliac joints (between the pelvis and spine) - At least two siblings in family with AS
Total Enrollment: 1600
Location and Contact Information:
Overall Study Official:
JohnReveille, Principal Investigator, University of Texas - Health Science Center at Houston
Cedars-Sinai Medical Center *Recruiting*
Los Angeles, California, 90048
United States
Recruiting Courtney McKinney 310-423-3032
University of Texas - Health Science Center at Houston *Recruiting*
Houston, Texas, 77030
United States
Recruiting Laura Diekman 713-500-6854
Additional Information:
Study ID Numbers: NIAMS-098; 5R01 AR046208-05,NASC
Study Start Date: September 1999
Record last reviewed: April 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00081562
Other Spondylitis Studies:
1. Genetic Determinants of Ankylosing Spondylitis Severity
2. Prevention of Arthritis-Related Work Disability
3. Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study
4. Phase II Pilot Study of Olsalazine for Ankylosing Spondylitis
5. Genetics of Ankylosing Spondylitis
Related Studies:
Other Spondylitis Clinical Trials
Other Texas Clinical Trials
Other Houston Clinical Trials
Genetics of Ankylosing Spondylitis
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