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Home > "G" Clinical Trials Conditions > Genetics, Metabolism and Weight Loss in Older, Obese Veterans  Genetics, Metabolism and Weight Loss in Older, Obese Veterans
Genetics, Metabolism and Weight Loss in Older, Obese Veterans
For Condition: Obesity
Status: Recruiting
Sponsor(s): Department of Veterans Affairs Medical Research Service ,
Synopsis: This study is designed to determine whether sequence variation in the lipoprotein lipase (LPQ) gene affects the amount of weight loss and metabolic responses during a hypocaloric diet treatment for overweight and obese (BMI=25-35 kg/m2), older (50-65 yrs), sedentary veterans.
Details: Veterans who are 50-65 yrs, non-smoking, sedentary and weight stable with a BMI between 25-35 kg/m2 (120-150% desirable body weight) are recruited and screened via telephone, medical history, and physical exam. Exclusion criteria are: diabetes, hypertriglyceridemia (>400 mg/dl), history of cancer or myocardial infarction, clinical depression, renal, liver or hematologic disease, and medications that affect glucose or lipid metabolism (thiazides, estrogen replacement, beta-blockers). Changes in total and visceral body fat are measured by dual x-ray absorptiometry and computerized tomography, resting energy expenditure and fat oxidation rate by indirect calorimetry, and lipoprotein lipids by enzymatic assay. Glucose tolerance is assessed during a three-hour oral glucose tolerance test with measurement of glucose- and insulin levels every 30 minutes. LPL activity is measured in 3050mg pieces of subcutaneous abdominal and gluteal adipose tissue.
Eligibility:
Study Type: Interventional, Treatment, Non-Randomized, Uncontrolled, Single Group Assignment, Efficacy Study
Minimum Age/Maximum Age: 50 Years/65 Years
Genders: Both
Protocol Entry Criteria: 50-65 yrs, non-smoking, sedentary and weight stable with a BMI between 25-35 kg/m2 (120-150% desirable body weight) are recruited and screened via telephone, medical history, and physical exam. Exclusion criteria are: diabetes, hypertriglyceridemia (>400 mg/dl), history of cancer or myocardial infarction, clinical depression, renal, liver or hematologic disease, and medications that affect glucose or lipid metabolism (thiazides, estrogen replacement, beta-blockers).
Total Enrollment:
Location and Contact Information:
VA Maryland Health Care System *Recruiting*
Baltimore, Maryland, 21201
United States
Recruiting Andrew Goldberg 410-605-7183
Additional Information:
Study ID Numbers: AGCG-006-98F;
Study Start Date: April 1999
Record last reviewed: June 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00018330
Other Obesity Studies:
1. Comparison of Popular Weight Loss Diets
2. Computer Assisted Instruction Weight Management for Low Literacy Populations
3. Women's Healthy Lifestyle Project: Cardiovascular Risk Factors and Menopause
4. Obese Patients with Type 2 Diabetes
5. Genetic Epidemiology of Blood Lipids and Obesity - Ancillary to NGHS
Related Studies:
Other Obesity Clinical Trials
Other Maryland Clinical Trials
Other Baltimore Clinical Trials
Genetics, Metabolism and Weight Loss in Older, Obese Veterans
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