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Genetic Study of Familial Epilepsy



Genetic Study of Familial Epilepsy

For Condition: Epilepsy
Status: Completed
Sponsor(s): National Center for Research Resources (NCRR) , Columbia University
Synopsis: OBJECTIVES: I. Determine the chromosomal regions that contain genes that raise the risk of epilepsy in families by performing genetic linkage analysis of idiopathic/cryptogenic epilepsy.
Details: PROTOCOL OUTLINE: Family histories are obtained, then the patients undergo an interview, a neurological examination, and EEG. Blood specimens are also collected. Linkage analysis is performed on specimens and analysis of shared marker alleles are used to identify genomic regions likely or unlikely to contain the epilepsy genes. Genotypes in family members are determined at microsatellite markers throughout the genome. Markers tested include chromosomes linked to human epilepsy syndromes (6p, 8p, 8q, 20q, 21q) and chromosome 3 (similar to mouse "epilepsy" genes). Linkage to markers on chromosome 10q are also tested. Patients do not receive the results of the testing and the results do not influence the type and duration of any treatment.
Eligibility:
Study Type:
  Observational, Screening
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- Male or female members of families with at least 1 close relative pair (sibling, half sibling, avuncular, grandparent-grandchild, or first cousin) affected with idiopathic/cryptogenic epilepsy that developed before age 25
Total Enrollment: 898

Location and Contact Information:

Overall Study Official:
RuthOttman,  Study Chair,  Columbia University

Columbia University College of Physicians and Surgeons
New York City,  New York,  10032
United States
 


Additional Information:
Study ID Numbers:
  NCRR-M01RR00645-2635;  CPMC-IRB-4465
Study Start Date: January 1997
Record last reviewed: December 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00006059

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