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Home > "G" Clinical Trials Conditions > Genetic Study of Brain Tumors in Young Children  Genetic Study of Brain Tumors in Young Children
Genetic Study of Brain Tumors in Young Children
For Condition: untreated childhood medulloblastoma,childhood choroid plexus tumor,untreated childhood supratentorial primitive neuroectodermal tumors,childhood rhabdoid tumor of the central nervous system
Status: Recruiting
Sponsor(s): Pediatric Brain Tumor Consortium , National Cancer Institute (NCI)
Synopsis: RATIONALE: Genetic studies may help in understanding the genetic processes involved in the development of some types of cancer. PURPOSE: Genetic study to understand how genes may be involved in the development of brain tumors in young children.
Details: OBJECTIVES: - Determine the frequency and type of deletions and mutations of the INI1 gene in infants with embryonal central nervous system tumors. - Compare the gene expression profiles in infants with atypical teratoid/rhabdoid tumors vs medulloblastoma or primitive neuroectodermal tumor. OUTLINE: This is a multicenter study. Tumor samples are analyzed by fluorescence in situ hybridization (FISH) for deletions of INI1 gene in chromosome band 22q11.2. Tumors without demonstration of deletions of INI1 gene by FISH are examined by polymerase chain reaction (PCR)-based microsatellite analysis for loss of heterozygosity using markers that map to 22q11.2. DNA from tumor tissue is analyzed for mutations in the exons of the INI1 gene. Isolated matched normal DNA may be analyzed for identification of germline mutations. Parental DNA may be analyzed to identify inherited germline mutations of the INI1 gene. The patient's physician may receive the results of the genetic testing. The results do not influence the type or duration of treatment. PROJECTED ACCRUAL: A total of 50 patients will be accrued for this study within 25 months.
Eligibility:
Study Type: Interventional, Diagnostic
Minimum Age/Maximum Age: /3 Years
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically confirmed primary intracranial central nervous system tumor - Medulloblastoma - Primitive neuroectodermal tumor - Atypical teratoid/rhabdoid tumor - Choroid plexus carcinoma - Potential enrollment on PBTC-001 therapeutic protocol PATIENT CHARACTERISTICS: Age: - Under 3 Performance status: - Not specified Life expectancy: - Not specified Hematopoietic: - Not specified Hepatic: - Not specified Renal: - Not specified PRIOR CONCURRENT THERAPY: Biologic therapy: - Not specified Chemotherapy: - No prior chemotherapy Endocrine therapy: - Prior steroids allowed Radiotherapy: - No prior radiotherapy Surgery: - Not specified Other: - No concurrent investigational agents
Total Enrollment:
Location and Contact Information:
Overall Study Official:
JaclynBiegel, Study Chair, Children's Hospital of Philadelphia
Baylor College of Medicine *Recruiting*
Houston, Texas, 77030
United States
Recruiting Susan Blaney 832-822-1482
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute *Recruiting*
Boston, Massachusetts, 02115
United States
Recruiting Mark Kieran 617-632-4907
UCSF Comprehensive Cancer Center *Recruiting*
San Francisco, California, 94115
United States
Recruiting Michael Prados 415-353-9510
Duke Comprehensive Cancer Center *Recruiting*
Durham, North Carolina, 27710
United States
Recruiting Henry Friedman 919-684-5301
Children's Hospital and Regional Medical Center - Seattle *Recruiting*
Seattle, Washington, 98105
United States
Recruiting J. Geyer 206-987-6664
Children's Hospital Boston *Recruiting*
Boston, Massachusetts, 02115
United States
Recruiting Scott Pomeroy 617-355-6874
Children's Hospital of Philadelphia *Recruiting*
Philadelphia, Pennsylvania, 19104-4318
United States
Recruiting Peter Phillips 215-590-2107
Children's Hospital of Pittsburgh *Recruiting*
Pittsburgh, Pennsylvania, 15213
United States
Recruiting Ian Pollack 412-692-5881
St. Jude Children's Research Hospital *Recruiting*
Memphis, Tennessee, 38105-2794
United States
Recruiting Larry Kun 901-495-3565
Children's National Medical Center *Recruiting*
Washington D.C., District of Columbia, 20010-2970
United States
Recruiting Roger Packer 202-884-2120
Additional Information:
Study ID Numbers: CDR0000068445; PBTC-N03
Study Start Date:
Record last reviewed: October 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00010101
Other Untreated Childhood Supratentorial Primitive Neuroectodermal Tumors Studies:
1. Gene Testing to Help in the Diagnosis and Treatment of Childhood Brain Tumors
2. Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Medulloblastoma or Supratentorial Primitive Neuroectodermal Tumor
3. Combination Chemotherapy Followed by Radiation Therapy in Treating Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma
4. Antineoplaston Therapy in Treating Children With Primitive Neuroectodermal Tumors
5. Combination Chemotherapy Followed by Second-Look Surgery and Radiation Therapy in Treating Children With Nonmetastatic Medulloblastoma or Primitive Neuroectodermal Tumor
Related Studies:
Other untreated childhood supratentorial primitive neuroectodermal tumors Clinical Trials
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Genetic Study of Brain Tumors in Young Children
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