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Home > "G" Clinical Trials Conditions > Genetic Study in Patients With Stage II or Stage III Colon Cancer  Genetic Study in Patients With Stage II or Stage III Colon Cancer
Genetic Study in Patients With Stage II or Stage III Colon Cancer
For Condition: stage 3 colon cancer,stage 2 colon cancer,adenocarcinoma of the colon
Status: No longer recruiting
Sponsor(s): North Central Cancer Treatment Group , National Cancer Institute (NCI),National Cancer Institute of Canada
Synopsis: RATIONALE: Genetic studies may help in understanding the genetic processes that cause some types of cancer. PURPOSE: Genetic trial to study certain genes of patients who have stage II or stage III colon cancer.
Details: OBJECTIVES: - Determine the adverse prognostic significance of 8p allelic imbalance (AI) in patients with colon cancer. - Determine if patient prognosis is dependent on the region of 8p AI. - Perform fine mapping studies to further localize the putative tumor suppressor gene(s) on 8p. - Perform multicolor FISH to examine the role that 8p loss and 8q gain play in the prognosis of patients whose tumors exhibit 8p AI. OUTLINE: Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8 markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136 at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping studies. PROJECTED ACCRUAL: Approximately 480 patients will be accrued for this study.
Eligibility:
Study Type: Interventional, Diagnostic
Minimum Age/Maximum Age: /69 Years
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Diagnosis of resectable stage II or III adenocarcinoma of the colon - Participated in NCCTG-914653 - DNA extracted from both normal and tumor tissue PATIENT CHARACTERISTICS: Age - Under 70 Performance status - Not specified Life expectancy - Not specified Hematopoietic - Not specified Hepatic - Not specified Renal - Not specified PRIOR CONCURRENT THERAPY: Biologic therapy - Not specified Chemotherapy - Not specified Endocrine therapy - Not specified Radiotherapy - Not specified Surgery - Not specified
Total Enrollment:
Location and Contact Information:
Overall Study Official:
RichardGoldberg, Study Chair, Mayo Clinic Cancer Center
G. Steinhoff Clinical Research
Victoria, British Columbia, V8V 3N1
Canada
Kells Medical Research Group Inc.
Pointe-Claire, Quebec, H9R 4S3
Canada
Centre Hospitalier Regional de Lanaudiere
Joliette, Quebec, J6E 6J2
Canada
Toronto Sunnybrook Regional Cancer Centre
Toronto, Ontario, M4N 3M5
Canada
British Columbia Cancer Agency - Fraser Valley Cancer Centre
Surrey, British Columbia, V3V 1Z2
Canada
Male Health Centre/CMX Research Inc.
Oakville, Ontario, L6H 3PI
Canada
St. Mary's/Duluth Clinic Health System
Duluth, Minnesota, 55805
United States
Centre Hospitalier Universitaire de Quebec
Quebec City, Quebec, G1R 2J6
Canada
McGill University
Montreal, Quebec, H2W 1S6
Canada
Hopital Charles Lemoyne
Greenfield Park, Quebec, J4V 2H1
Canada
Lions Gate Hospital
North Vancouver, , V7L 2P9
Canada
Cancer Care Ontario - Windsor Regional Cancer Centre
Windsor, Ontario, N8W 2X3
Canada
Hotel Dieu Health Sciences Hospital - Niagara
St. Catharines, Ontario, L2R 5K3
Canada
Northeastern Ontario Regional Cancer Centre, Sudbury
Sudbury, Ontario, P3E 5J1
Canada
Maisonneuve-Rosemont Hospital
Montreal, Quebec, H1T 2M4
Canada
Humber River Regional Hospital
Weston, Ontario, M9N 1N8
Canada
Trillium Health Centre
Mississauga, Ontario, L5B 1B8
Canada
St. Michael's Hospital - Toronto
Toronto, Ontario, M5B 1W8
Canada
Ottawa Regional Cancer Centre
Ottawa, Ontario, K1H 1C4
Canada
Lakeridge Health Oshawa
Oshawa, Ontario, L1G 2B9
Canada
Saint Joseph's Health Centre - Toronto
Toronto, Ontario, M6R 1B5
Canada
Centre Hospitalier de l'Universite de Montreal
Montreal, Quebec, (P.Q.) H2X 3J4
Canada
Saint John Regional Hospital
Saint John, New Brunswick, E2L 4L2
Canada
Allan Blair Cancer Centre
Regina, Saskatchewan, S4T 7T1
Canada
Newfoundland Cancer Treatment and Research Foundation
St. Johns, Newfoundland and Labrador, A1B 3V6
Canada
Royal Victoria Hospital, Barrie
Barrie, Ontario, L4M 6M2
Canada
Hopital Sainte Justine
Montreal, Quebec, H3T 1C5
Canada
Credit Valley Hospital
Mississauga, Ontario, L5M 2N1
Canada
Lethbridge Cancer Clinic
Lethbridge, Alberta, T1J 1W5
Canada
Nova Scotia Cancer Centre
Halifax, Nova Scotia, B3H 1V7
Canada
Queen Elizabeth Hospital, PEI
Charlottetown, Prince Edward Island, C1A 8T5
Canada
York County Hospital
Newmarket, Ontario, L3Y 2P9
Canada
St. Paul's Hospital - Vancouver
Vancouver, British Columbia, V6Z 1Y6
Canada
Scarborough Hospital - General Site
Scarborough, Ontario, M1P 2V5
Canada
Hopital du Saint-Sacrament, Quebec
Quebec City, Quebec, G1S 4L8
Canada
Hamilton and District Urology Association
Hamilton, Ontario, L8N 1T8
Canada
Markham Stouffville Hospital
Markham, Ontario, L3P 7T3
Canada
Nanaimo Cancer Clinic
Nanaimo, British Columbia, V9S 2B7
Canada
Toronto East General Hospital
Toronto, Ontario, M4C 3E7
Canada
Doctor Leon Richard Oncology Centre
Moncton, New Brunswick, E1C 8X3
Canada
Cape Breton Cancer Centre
Sydney, Nova Scotia, B1P 1P3
Canada
CHUS-Hopital Fleurimont
Fleurimont, Quebec, J1H 5N4
Canada
Prostate Centre at Vancouver General Hospital
Vancouver, British Columbia, V5Z 3J5
Canada
William Osler Health Centre
Brampton, Ontario, L6W 2Z8
Canada
North York General Hospital, Ontario
North York, Ontario, M2K 1E1
Canada
Princess Margaret Hospital
Toronto, Ontario, M5G 2M9
Canada
Tom Baker Cancer Center - Calgary
Calgary, Alberta, T2N 4N2
Canada
Northwestern Ontario Regional Cancer Centre, Thunder Bay
Thunder Bay, Ontario, P7A 7T1
Canada
British Columbia Cancer Agency
Vancouver, British Columbia, V5Z 4E6
Canada
Mount Sinai Hospital - Toronto
Toronto, Ontario, M5G 1X5
Canada
Moncton Hospital
Moncton, New Brunswick, E1C 6ZB
Canada
Toronto General Hospital
Toronto, Ontario, M5G 2C4
Canada
L'Hopital Laval
Ste Foy, Quebec, G1V 4G5
Canada
Hopital Du Sacre-Coeur de Montreal
Montreal, Quebec, H4J 1C5
Canada
Centre Hospitalier Regional de Rimouski
Rimouski, Quebec, G5L 5T1
Canada
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, S7N 4H4
Canada
Women's College Campus, Sunnybrook and Women's College Health Science Center
Toronto, Ontario, M5S 1B6
Canada
Peterborough Oncology Clinic
Peterborough, Ontario, K9H 7B6
Canada
London Health Sciences Centre
London, Ontario, N6A 4G5
Canada
Additional Information:
Study ID Numbers: CDR0000066990; NCCTG-984654,CAN-NCIC-CO9PATH
Study Start Date:
Record last reviewed: May 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00003833
Other Stage 3 Colon Cancer Studies:
1. ZD 1839 in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer That Has Not Responded to Chemotherapy
2. Comparison of Adjuvant Combination Chemotherapy Regimens in Treating Patients With Resected Stage III Colon Cancer
3. Neoadjuvant Radiation Therapy and Capecitabine in Treating Patients With Stage III or Stage IV Colorectal Adenocarcinoma
4. Combination Chemotherapy in Treating Patients With Colorectal Cancer
5. Comparison of Sulindac, Aspirin, and Ursodiol in Preventing Colorectal Cancer
Related Studies:
Other stage 3 colon cancer Clinical Trials
Other Ontario Clinical Trials
Other Oakville Clinical Trials
Genetic Study in Patients With Stage II or Stage III Colon Cancer
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