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Home > "G" Clinical Trials Conditions > Genetic Studies in Alzheimer's Disease  Genetic Studies in Alzheimer's Disease
Genetic Studies in Alzheimer's Disease
For Condition: Alzheimer's Disease,Nervous System Disease
Status: Completed
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) ,
Synopsis: Alzheimer's disease is a condition marked by the deterioration of mental function. The disease usually begins in late middle life and results in death in 5 to 10 years. Patients with Alzheimer's disease typically suffer from memory loss, confusion, and disorientation. The condition has become a major medical and social problem in the United States because of the increasing number of people living beyond the age of 65. The actual cause of Alzheimer's disease is unknown. Researchers believe that Alzheimer's disease, or at least a portion of cases, may be an inherited condition. As a result, many new techniques have been developed to study the genetic causes of Alzheimer's disease and other neurological disorders. Many of these genetic techniques require blood samples and a family pedigree. A pedigree is a chart, similar to a family tree, that shows a patient's family history. The purpose of this study is to collect family and psychosocial information, blood, and biopsy samples from patients with neurological diseases, their families, and normal volunteers. This information gathered will be used to learn more about diseases that affect the brain.
Details: This is a screening and follow-up Protocol. Recent technological advances have facilitated the development of new approaches for investigating the underlying genetic basis of neurological disorders, but genetic questions remain open and on going. Application of many genetic techniques require a family pedigree and blood sample. Peripheral blood lymphoblasts which are banked also serve as a renewable source for harvesting DNA which can be used for developing genetic markers in the future. This study will allow collection of family and psychosocial information and blood specimens from patients with neurological diseases, their families, and normal control subjects.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION/EXCLUSION CRITERIA Need to know extensive family history information.
Total Enrollment: 1500
Location and Contact Information:
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 880029; 88-N-0029
Study Start Date: February 16, 1988
Record last reviewed: February 9, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001235
Other Nervous System Disease Studies:
1. Safety and Tolerability Study of Extended Release (ER) Galantamine in Alzheimer’s Disease
2. High Intensity Light Therapy in Alzheimer's Disease
3. Alzheimer's Disease and Aging: Therapeutic potential of estrogen
4. CATIE-Alzheimer's Disease Trial
5. Ginkgo Biloba Prevention Trial in Older Individuals
Related Studies:
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Genetic Studies in Alzheimer's Disease
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