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Genetic Registry for Rheumatoid Arthritis



Genetic Registry for Rheumatoid Arthritis

For Condition: Rheumatoid Arthritis
Status: Recruiting
Sponsor(s): National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) , National Institute of Allergy and Infectious Diseases (NIAID),Arthritis Foundation
Synopsis: Many genes are thought to contribute to rheumatoid arthritis (RA). Currently only one such gene has been identified. This study will attempt to identify all of the genes that may contribute to RA and determine which specific genetic variations are responsible for the disease.
Details: The identification of genes for complex disorders such as RA requires large numbers of genetically informative families. This study will enroll patients with RA and their families. Participants with RA will be evaluated by a study official at his or her doctor's office or other location convenient for the participant. Participants will have a brief interview and physical exam and a blood sample will be obtained. Disease evaluation will be done at one visit and will include a 28 joint count, joint alignment and mobility score (JAMS), hand X-ray, administration of a health assessment questionnaire and other related questionnaires. Physician confirmation of diagnosis will also be included in the disease evaluation.
Eligibility:
Study Type:  Observational, Screening, Cross-Sectional, Defined Population, Retrospective/Prospective Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria - Adult onset, seropositive, erosive rheumatoid arthritis (RA) - Diagnosis of RA made between 18 and 60 years old - Both parents alive and willing to participate - Parents may have diagnosis of RA (affected) or be unaffected Exclusion Criteria - Inflammatory bowel disease - Lupus - Psoriatic arthritis
Total Enrollment: 1000

Location and Contact Information:

Overall Study Official:
PeterGregersen,  Principal Investigator,  North Shore University Hospital

North Shore Long Island Jewish Research Institute *Recruiting*
Manhasset,  New York,  11030
United States
Recruiting Marlena  Kern 516-562-2244


Additional Information:
Study ID Numbers:  NIAMS-107; 
Study Start Date: October 2002
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00069472

Other Rheumatoid Arthritis Studies:
1. dnaJ Peptide for Relieving Rheumatoid Arthritis

2. Treatment of Rheumatoid Arthritis with Marine and Botanical Oils

3. A Safety Study of Escalating Doses of PRO70769 for Subjects with Moderate to Severe Rheumatoid Arthritis Receiving Stable Doses of Concomitant Methotrexate

4. Relaxation Response Training for the Treatment of Rheumatoid Arthritis

5. Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases

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