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Genetic Component of Handedness Clinical Trials Data presented on Clinical Trials Search isn't meant to be a substitute for qualified health advice, calls or treatment using a genuine doctor. We are not docs. Always consult your dr. on Genetic Component of Handedness conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Genetic Component of Handedness Clinical research trials and Genetic Component of Handedness healthcare trials occur in a lot of of places throughout the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the potency of new drugs. The intent of the studies / undertakings is to figure out certain human medical questions. Clinical trials are a popular means for mDs, government agencies, and private sector corporations to locate remedies for all kinds of circumstances, including Genetic Component of Handedness. Genetic Component of Handedness Clinical Trials and other clinical trials allow volunteers to obtain health treatment alternatives before they are available to the masses. Many times the participants undergo treatment for free, and sometimes they are paid for their time. Occasionally there is a cost for a Genetic Component of Handedness clinical trial. Participants typically obtain the most effective healthcare available for their Genetic Component of Handedness condition. Dangers are a reality, nonetheless, and can include extra or frequent mD trips, medical hazards (potentially life-endangering), and/or the treatment being uneffective. Trials are federally regulated with rigid guidelines to protect clinical trials patients.
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Home > "G" Clinical Trials Conditions > Genetic Component of Handedness  Genetic Component of Handedness
Genetic Component of Handedness
For Condition: Healthy
Status: No longer recruiting
Sponsor(s): National Cancer Institute (NCI) ,
Synopsis: Some functions are generally controlled by the right side of the brain and others by the left. One of the most easily observed examples of this "lateral specialization" of the brain is handedness-that is, a person's preference for using either the right or the left hand. This study will try to determine how the genetic component of handedness is inherited. It will test the theory that a single gene is involved in determining handedness and will try to locate the gene. Families with at least two left-handed siblings aged eight years or older and at least one right-handed parent are eligible to participate in this study. The left-handed siblings and both parents will fill out a brief questionnaire on hand usage, obtain a tissue sample taken from inside the cheek, and return the questionnaire and the sample by mail to the study researchers. The tissue sample will be used for DNA gene mapping. Participants will be given a kit and instructions for obtaining the sample, along with mailing envelopes. Cheek swab sampling basically involves using a small brush to gently brush a layer of cells off of the inner wall of the cheek and then dropping the brush tip into a preservative. The information gained from this study may provide insight into aspects of brain development that can be of medical benefit in the future.
Details: The purpose of this protocol, based on the hypothesis that human hand-use preference (handedness) is largely dependent on the action of a single locus, is to collect samples allowing us to map a "handedness gene" via detection of linkage to any of eight potential candidate genes/regions or via a whole or partial genome scan. We calculate that a full 300 marker genome scan of 100 parents and sibling pairs (allowing linkage analysis at 10 cM resolution), or the equivalent amount of data from partial scans of 300 families, has a high likelihood of allowing us to map the proposed gene. Eligible families, consisting of pairs of left-handed siblings plus at least one right-handed parent, were identified during Phase I of this study in 1996-1998, with approval from the now-lapsed FCRDC IRB. In Phase II of this study, we have collected cheek swab samples for DNA isolation from members of 100 eligible families for use in the mapping studies. DNA samples will not be linked back to individuals but grouped under a random family code that links to a database with limited information, including hand use preference and family structure. In the next phase, we wish to map the locus from cheek swab samples we have on hand.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Members of families meeting the following criteria are eligible to participate: Have two left-handed siblings. Have at least one right-handed parent with no other known left-handed first degree relatives. EXCLUSION CRITERIA: All members of a family may be excluded if the right-handed parents or the left-handed siblings will not participate. Individuals in families whose left-handed siblings are under the age of eight are not eligible to participate.
Total Enrollment: 1400
Location and Contact Information:
National Cancer Institute (NCI)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 000094; 00-C-0094
Study Start Date: March 21, 2000
Record last reviewed: March 1, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00005003
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Genetic Component of Handedness
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